{"id":"https://openalex.org/W2005182745","doi":"https://doi.org/10.1371/journal.pone.0042295","title":"Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential","display_name":"Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential","publication_year":2012,"publication_date":"2012-08-06","ids":{"openalex":"https://openalex.org/W2005182745","doi":"https://doi.org/10.1371/journal.pone.0042295","mag":"2005182745","pmid":"https://pubmed.ncbi.nlm.nih.gov/22879935","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412869"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0042295","doi":"https://doi.org/10.1371/journal.pone.0042295","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042295","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042295&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042295&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066108608","display_name":"Qinlian Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinlian Zhou","raw_affiliation_strings":["Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Biomedical Engineering, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Biomedical Engineering, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089811873","display_name":"Glenna C.L. Bett","orcid":"https://orcid.org/0000-0003-2405-6562","observed_orcids":["https://orcid.org/0000-0003-2405-6562"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenna C. L. Bett","raw_affiliation_strings":["Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Gynecology-Obstetrics, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Gynecology-Obstetrics, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109115329","display_name":"Randall L. Rasmusson","orcid":"https://orcid.org/0009-0005-6641-7209","observed_orcids":["https://orcid.org/0009-0005-6641-7209"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall L. Rasmusson","raw_affiliation_strings":["Biomedical Engineering, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Center for Cellular and Systems Electrophysiology, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Physiology and Biophysics, State University of New York, University at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109115329"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.4117,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70111321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"8","first_page":"e42295","last_page":"e42295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transient-outward-potassium-current","display_name":"transient outward potassium current","score":0.765999972820282},{"id":"https://openalex.org/keywords/kv4-2","display_name":"Kv4.2","score":0.7390000224113464},{"id":"https://openalex.org/keywords/kv4-3","display_name":"Kv4.3","score":0.9549999833106995},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.843999981880188},{"id":"https://openalex.org/keywords/markov-channel-model","display_name":"Markov channel model","score":0.7630000114440918},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cardiac-action-potential","display_name":"cardiac action potential","score":0.4390000104904175},{"id":"https://openalex.org/keywords/pacing-rate","display_name":"pacing rate","score":0.4749999940395355},{"id":"https://openalex.org/keywords/mouse-heart","display_name":"mouse heart","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6106931567192078},{"id":"https://openalex.org/C79743260","wikidata":"https://www.wikidata.org/wiki/Q2882301","display_name":"Cardiac action potential","level":4,"score":0.5915884375572205},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5836518406867981},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.5338795185089111},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5178025960922241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5034715533256531},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48555466532707214},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4614149332046509},{"id":"https://openalex.org/C2778457506","wikidata":"https://www.wikidata.org/wiki/Q7234689","display_name":"Potassium channel blocker","level":3,"score":0.4592682123184204},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.44431233406066895},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.4333607852458954},{"id":"https://openalex.org/C2910096629","wikidata":"https://www.wikidata.org/wiki/Q241549","display_name":"Anti-Arrhythmia Agents","level":3,"score":0.42715051770210266},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.38814547657966614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24393323063850403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24112185835838318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23802971839904785},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.19710734486579895},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14473751187324524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1412426233291626},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0042295","doi":"https://doi.org/10.1371/journal.pone.0042295","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042295","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042295&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3412869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3412869","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22879935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22879935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.790.415","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.415","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/85/8c/pone.0042295.PMC3412869.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0042295","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042295","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a980f126468b4a07897126871965e24b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a980f126468b4a07897126871965e24b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 8, p e42295 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/121549","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Markov_Models_of_Use_Dependence_and_Reverse_Use_Dependence_during_the_Mouse_Cardiac_Action_Potential/121549","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0042295","doi":"https://doi.org/10.1371/journal.pone.0042295","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0042295","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042295&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1746938211","display_name":null,"funder_award_id":"HL062465","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2557069002","display_name":null,"funder_award_id":"R01-HL062465","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4727552510","display_name":"Sex Differences in Molecular Heterogeneity of Cardiac Repolarization","funder_award_id":"R21HL093631","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4887126375","display_name":null,"funder_award_id":"HL093631","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4989129102","display_name":"Markov Models of Potassium Channel Gating","funder_award_id":"5r01hl062465-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5543421996","display_name":"Myocardial Properties of Timothy Syndrome","funder_award_id":"R21HL088058","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8715118709","display_name":null,"funder_award_id":"HL088058","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005182745.pdf","grobid_xml":"https://content.openalex.org/works/W2005182745.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1526621956","https://openalex.org/W1534708542","https://openalex.org/W1912882743","https://openalex.org/W1965371036","https://openalex.org/W1966943380","https://openalex.org/W1969225450","https://openalex.org/W1971612733","https://openalex.org/W1975275471","https://openalex.org/W1983137097","https://openalex.org/W1986359646","https://openalex.org/W1989499645","https://openalex.org/W1991781357","https://openalex.org/W2002374666","https://openalex.org/W2003187190","https://openalex.org/W2006090981","https://openalex.org/W2008373413","https://openalex.org/W2025203994","https://openalex.org/W2025238295","https://openalex.org/W2047862560","https://openalex.org/W2089501409","https://openalex.org/W2092248363","https://openalex.org/W2096056146","https://openalex.org/W2098061246","https://openalex.org/W2107763854","https://openalex.org/W2110565291","https://openalex.org/W2113176279","https://openalex.org/W2113927644","https://openalex.org/W2114940281","https://openalex.org/W2117287580","https://openalex.org/W2125991462","https://openalex.org/W2131308754","https://openalex.org/W2131609026","https://openalex.org/W2133877071","https://openalex.org/W2138323127","https://openalex.org/W2143511208","https://openalex.org/W2152136740","https://openalex.org/W2156668426","https://openalex.org/W2159084460","https://openalex.org/W2159808944","https://openalex.org/W2160405977","https://openalex.org/W2160626604","https://openalex.org/W2161839172","https://openalex.org/W2398350456","https://openalex.org/W2401421706","https://openalex.org/W2413806819"],"related_works":["https://openalex.org/W2276902544","https://openalex.org/W2020905073","https://openalex.org/W1977248262","https://openalex.org/W2312208500","https://openalex.org/W1969225450","https://openalex.org/W2017646028","https://openalex.org/W2167902187","https://openalex.org/W2075503729","https://openalex.org/W2024157977","https://openalex.org/W2011391996"],"abstract_inverted_index":{"The":[0,17],"fast":[1],"component":[2],"of":[3,15,21,53,70,88],"the":[4,51,71,110,115,127,132,191],"cardiac":[5],"transient":[6],"outward":[7],"current,":[8],"I(Ktof),":[9,81],"is":[10],"blocked":[11],"by":[12],"a":[13,94,120,158],"number":[14],"drugs.":[16],"major":[18],"molecular":[19],"bases":[20],"I(Ktof)":[22],"are":[23,181],"Kv4.2/Kv4.3":[24],"voltage-gated":[25],"potassium":[26],"channels.":[27],"Drugs":[28],"with":[29,56],"similar":[30,144],"potencies":[31],"but":[32,188],"different":[33,57],"blocking":[34,58],"mechanisms":[35,59,142],"have":[36],"differing":[37],"effects":[38,87,145,178],"on":[39,60,124,161,179,186,190],"action":[40,72],"potential":[41],"duration":[42],"(APD).":[43],"We":[44,64,85],"used":[45,65],"in":[46],"silico":[47],"analysis":[48],"to":[49,108,114,131],"determine":[50],"effect":[52,123,160],"I(Ktof)-blocking":[54],"drugs":[55],"mouse":[61,68],"ventricular":[62],"myocytes.":[63],"our":[66,173],"existing":[67],"model":[69],"potential,":[73],"and":[74,97],"developed":[75],"4":[76],"new":[77],"Markov":[78],"formulations":[79],"for":[80],"I(Ktos),":[82],"I(Kur),":[83],"I(Ks).":[84],"compared":[86],"theoretical":[89],"I(Ktof)-specific":[90],"channel":[91,101],"blockers:":[92],"(1)":[93],"closed":[95,133],"state,":[96],"(2)":[98],"an":[99,152],"open":[100,116,153],"blocker.":[102],"At":[103,135],"concentrations":[104,136],"lower":[105],"or":[106],"close":[107],"IC(50),":[109,140,187],"drug":[111,128,156,177,192],"which":[112,129],"bound":[113,130],"state":[117,154],"always":[118],"had":[119,143,157],"much":[121,137],"greater":[122,159],"APD":[125,162,180],"than":[126,139],"state.":[134,194],"higher":[138],"both":[141],"at":[146,163],"very":[147],"low":[148],"pacing":[149,165],"rates.":[150],"However,":[151],"binding":[155,193],"faster":[164],"rates,":[166],"particularly":[167],"around":[168],"10":[169],"Hz.":[170],"In":[171],"summary,":[172],"data":[174],"indicate":[175],"that":[176],"strongly":[182],"dependent":[183],"not":[184],"only":[185],"also":[189]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}