{"id":"https://openalex.org/W2005181042","doi":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","title":"5-azacytidine in acute leukemia","display_name":"5-azacytidine in acute leukemia","publication_year":1978,"publication_date":"1978-11-01","ids":{"openalex":"https://openalex.org/W2005181042","doi":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","mag":"2005181042","pmid":"https://pubmed.ncbi.nlm.nih.gov/82472"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","doi":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110390183","display_name":"John H. Saiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. H. Saiki","raw_affiliation_strings":["Associate Professor Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109105424","display_name":"KENNETH B. McCREDIE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. B. McCredie","raw_affiliation_strings":["Associate Professor of Medicine. University of Texas Medical Center, Houston, Texas","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Medicine. University of Texas Medical Center, Houston, Texas","institution_ids":["https://openalex.org/I1337852284"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112074801","display_name":"Teresa J. Vietti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. J. Vietti","raw_affiliation_strings":["Professor of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112097344","display_name":"James S. Hewlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. S. Hewlett","raw_affiliation_strings":["Head, Department of Hematology-Oncology, Cleveland Clinic, Cleveland, Ohio","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head, Department of Hematology-Oncology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113700857","display_name":"Francis S. Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. S. Morrison","raw_affiliation_strings":["Professor of Medicine, Director of Division of Hematology. University of Mississippi Medical Center, Jackson, Mississippi","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine, Director of Division of Hematology. University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108444709","display_name":"J J Costanzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. Costanzi","raw_affiliation_strings":["Associate Professor of Medicine, University of Texas Medical Center, Galveston, Texas","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Medicine, University of Texas Medical Center, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034825378","display_name":"Walter J. Stuckey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. J. Stuckey","raw_affiliation_strings":["Professor of Medicine, Tulane University School of medicine, New Orleans, Louisiana","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine, Tulane University School of medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027547716","display_name":"John P. Whitecar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289568071","display_name":"Brooke Army Medical Center","ror":"https://ror.org/00m1mwc36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289568071","https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Whitecar","raw_affiliation_strings":["Private Practice in the Subspecialty of Medical Oncology, formerly Chief of Medical Oncology Section, Brooke Army Medical Center, Fort Sam Houston, Texas","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice in the Subspecialty of Medical Oncology, formerly Chief of Medical Oncology Section, Brooke Army Medical Center, Fort Sam Houston, Texas","institution_ids":["https://openalex.org/I1289568071"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033453413","display_name":"Barth Hoogstraten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Hoogstraten","raw_affiliation_strings":["Professor of Medicine, University of Kansas Medical Center. Kansas City, Kansas","Southwest Oncology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine, University of Kansas Medical Center. Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Southwest Oncology Group","institution_ids":["https://openalex.org/I4210165553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5110390183"],"corresponding_institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4210165553"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.3771,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.79575364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"5","first_page":"2111","last_page":"2114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":1.0},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/relapsed-leukemia","display_name":"relapsed leukemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/acute-myelomonocytic-leukemia","display_name":"acute myelomonocytic leukemia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/treatment-schedule","display_name":"treatment schedule","score":0.5950000286102295},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7739999890327454},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/antileukemic-activity","display_name":"antileukemic activity","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9017188549041748},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6649917364120483},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5155649185180664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25220686197280884}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012075","descriptor_name":"Remission, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","doi":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(197811)42:5<2111::aid-cncr2820420505>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:82472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/82472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W46662938","https://openalex.org/W1517594014","https://openalex.org/W1575975667","https://openalex.org/W1976889521"],"related_works":["https://openalex.org/W2013657344","https://openalex.org/W2113231065","https://openalex.org/W1575975667","https://openalex.org/W2061160794","https://openalex.org/W2029382816","https://openalex.org/W2394698142","https://openalex.org/W46662938","https://openalex.org/W1976889521","https://openalex.org/W7097481119","https://openalex.org/W194925807"],"abstract_inverted_index":{"101":[0],"patients":[1,55,76,108,115,151,160],"with":[2,9],"acute":[3,189],"leukemia":[4],"in":[5,187],"relapse":[6],"were":[7,97,122],"treated":[8],"5-azacytidine":[10,183],"according":[11],"to":[12,39,99,171],"three":[13],"schedules:":[14],"Regimen":[15,27,44,125,129,136],"A--300":[16],"mg/m2(day":[17],"divided":[18],"intravenously":[19],"at":[20,37],"8":[21,134],"hour":[22],"intervals":[23],"for":[24,51,68,113,124,128,135,141],"5":[25,52,95,118],"days;":[26],"B--750":[28],"mg/m2":[29],"as":[30],"a":[31,57,64,92,101,153,166],"single":[32],"iv":[33],"pulse":[34],"dose":[35],"administered":[36],"2":[38,156],"3":[40],"weeks":[41,96,111],"intervals;":[42],"and":[43,61,91,112,131,143,174,180],"C--300":[45],"mg/m2/day":[46],"by":[47],"continuous":[48],"infusion":[49],"daily":[50],"days.":[53],"Twelve":[54],"achieved":[56,63,152,165],"complete":[58],"remission":[59,66],"(CR)":[60],"six":[62],"partial":[65],"(PR)":[67],"an":[69,78],"overall":[70],"18%":[71],"response":[72,82],"rate.":[73],"Of":[74],"78":[75],"receiving":[77],"adequate":[79],"trial":[80],"the":[81,188],"rate":[83,140],"was":[84,109,117,145],"23%.":[85],"An":[86],"average":[87],"of":[88,94,106,133,148,157,163],"1.5":[89],"courses":[90],"median":[93,104],"necessary":[98],"achieve":[100],"response.":[102],"The":[103,138],"duration":[105],"CR":[107,139],"21":[110],"PR":[114],"it":[116],"weeks.":[119],"Response":[120],"rates":[121],"24%":[123],"A,":[126],"0":[127],"B,":[130],"1":[132],"C.":[137],"AML":[142],"AMML":[144],"13%.":[146],"Two":[147],"eight":[149],"AMoL":[150],"CR.":[154,167],"Only":[155],"23":[158],"ALL":[159],"responded,":[161],"one":[162],"whom":[164],"Toxicity":[168],"included":[169],"moderate":[170],"severe":[172],"nausea":[173],"vomiting,":[175],"diarrhea,":[176],"stomatitis,":[177],"skin":[178],"rash,":[179],"prolonged":[181],"myelosuppression.":[182],"has":[184],"significant":[185],"activity":[186],"nonlymphoblastic":[190],"leukemias.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}