{"id":"https://openalex.org/W2005179441","doi":"https://doi.org/10.1016/s0006-291x(05)80767-3","title":"Effect of bufalin and pregnanes on vasoreactivity of human resistance arteries","display_name":"Effect of bufalin and pregnanes on vasoreactivity of human resistance arteries","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2005179441","doi":"https://doi.org/10.1016/s0006-291x(05)80767-3","mag":"2005179441","pmid":"https://pubmed.ncbi.nlm.nih.gov/1378719"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-291x(05)80767-3","doi":"https://doi.org/10.1016/s0006-291x(05)80767-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(05)80767-3","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108522942","display_name":"Robin G. Woolfson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.G. Woolfson","raw_affiliation_strings":["Division of Physiology, United Medical School, Guys Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiology, United Medical School, Guys Hospital, London, UK","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Graves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Graves","raw_affiliation_strings":["Division of Physiology, United Medical and Dental Schools of Guys and St.Thomas' Hospitals, London SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiology, United Medical and Dental Schools of Guys and St.Thomas' Hospitals, London SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108586101","display_name":"Frank S. LaBella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F.S. Labella","raw_affiliation_strings":["Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, CANADA R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, CANADA R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718692","display_name":"John F. Templeton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J.F. Templeton","raw_affiliation_strings":["Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, CANADA R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, CANADA R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045203195","display_name":"Lucilla Poston","orcid":"https://orcid.org/0000-0003-1100-2821","observed_orcids":["https://orcid.org/0000-0003-1100-2821"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"L Poston","raw_affiliation_strings":["Division of Physiology, United Medical and Dental Schools of Guys and St.Thomas' Hospitals, London SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiology, United Medical and Dental Schools of Guys and St.Thomas' Hospitals, London SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045203195"],"corresponding_institution_ids":["https://openalex.org/I1324925910"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.1048,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73179761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"186","issue":"1","first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bufalin","display_name":"bufalin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pregnanes","display_name":"pregnane derivatives","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.8159999847412109},{"id":"https://openalex.org/keywords/na-k-atpase-inhibition","display_name":"Na+/K+-ATPase inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/vasoreactivity","display_name":"vasoreactivity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/resistance-arteries","display_name":"resistance arteries","score":0.8230000138282776},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.7310000061988831},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/human-arteries","display_name":"human arteries","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2777151579","wikidata":"https://www.wikidata.org/wiki/Q18379323","display_name":"Bufalin","level":3,"score":0.7074994444847107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5168164968490601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.450111985206604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37806951999664307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21179836988449097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13999533653259277},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002018","descriptor_name":"Bufanolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002715","descriptor_name":"Chlormadinone Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008419","descriptor_name":"Materia Medica","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011278","descriptor_name":"Pregnanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-291x(05)80767-3","doi":"https://doi.org/10.1016/s0006-291x(05)80767-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(05)80767-3","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:1378719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1378719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1970445852","https://openalex.org/W2001243825","https://openalex.org/W2026892128","https://openalex.org/W2041423585","https://openalex.org/W2072091469","https://openalex.org/W2076757239","https://openalex.org/W2078302169","https://openalex.org/W2078491826","https://openalex.org/W2082287999","https://openalex.org/W2098963490","https://openalex.org/W2121020585","https://openalex.org/W2154909429","https://openalex.org/W2159971539","https://openalex.org/W2218812945","https://openalex.org/W2403807052","https://openalex.org/W2413285631"],"related_works":["https://openalex.org/W1567480028","https://openalex.org/W2142992132","https://openalex.org/W2215682421","https://openalex.org/W2321934742","https://openalex.org/W7098955894","https://openalex.org/W2014950683","https://openalex.org/W2051428533","https://openalex.org/W1995882375","https://openalex.org/W2019183152","https://openalex.org/W2319756899"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}