{"id":"https://openalex.org/W2005175560","doi":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","title":"The effect of smoking on the response to raloxifene treatment in postmenopausal osteoporosis","display_name":"The effect of smoking on the response to raloxifene treatment in postmenopausal osteoporosis","publication_year":2012,"publication_date":"2012-12-13","ids":{"openalex":"https://openalex.org/W2005175560","doi":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","mag":"2005175560"},"language":"en","primary_location":{"id":"doi:10.5799/ahinjs.01.2012.04.0202","doi":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","is_oa":true,"landing_page_url":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","pdf_url":"https://www.jceionline.org/download/the-effect-of-smoking-on-the-response-to-raloxifene-treatment-in-postmenopausal-osteoporosis-3372.pdf","source":{"id":"https://openalex.org/S2736377337","display_name":"Journal of Clinical and Experimental Investigations","issn_l":"1309-6621","issn":["1309-6621","1309-8578"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318340","host_organization_name":"Association of Health Investigations","host_organization_lineage":["https://openalex.org/P4310318340"],"host_organization_lineage_names":["Association of Health Investigations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Experimental Investigations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jceionline.org/download/the-effect-of-smoking-on-the-response-to-raloxifene-treatment-in-postmenopausal-osteoporosis-3372.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019875761","display_name":"G\u00fclin Feykan Ye\u011fin","orcid":"https://orcid.org/0000-0001-8006-5055","observed_orcids":["https://orcid.org/0000-0001-8006-5055"]},"institutions":[{"id":"https://openalex.org/I4210094564","display_name":"Ankara Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00kmzyw28","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210094564","https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fclin Feykan Ye\u011fin","raw_affiliation_strings":["Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210094564"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sava\u015f Erdem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094564","display_name":"Ankara Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00kmzyw28","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210094564","https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sava\u015f Erdem","raw_affiliation_strings":["Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","institution_ids":["https://openalex.org/I4210094564"]},{"raw_affiliation_string":"Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210094564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109459070","display_name":"Ay\u015fe Filiz Av\u015far","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094564","display_name":"Ankara Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00kmzyw28","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210094564","https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Filiz Av\u015far","raw_affiliation_strings":["Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210094564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068165919","display_name":"H\u00fcseyin Levent Keskin","orcid":"https://orcid.org/0000-0002-2268-3821","observed_orcids":["https://orcid.org/0000-0002-2268-3821"]},"institutions":[{"id":"https://openalex.org/I4210094564","display_name":"Ankara Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00kmzyw28","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210094564","https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fcseyin Levent Keskin","raw_affiliation_strings":["Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","institution_ids":["https://openalex.org/I4210094564"]},{"raw_affiliation_string":"Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210094564"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037231580","display_name":"El\u00e7in \u0130\u015flek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094564","display_name":"Ankara Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00kmzyw28","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210094564","https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"El\u00e7in \u0130\u015flek","raw_affiliation_strings":["Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics , Atat\u00fcrk Education and Research Hospital , Ankara , Turkey","institution_ids":["https://openalex.org/I4210094564"]},{"raw_affiliation_string":"Dept. Gynecology and Obstetrics, Atat\u00fcrk Education and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210094564"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094564"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14211901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9539999961853027},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.996999979019165},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8790000081062317},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.828000009059906},{"id":"https://openalex.org/keywords/t-score","display_name":"T-score","score":0.6340000033378601},{"id":"https://openalex.org/keywords/calcium-and-vitamin-d-supplementation","display_name":"calcium and vitamin D supplementation","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.966144323348999},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.8468667268753052},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7671356201171875},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.631197452545166},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.5015163421630859},{"id":"https://openalex.org/C2776548296","wikidata":"https://www.wikidata.org/wiki/Q2351537","display_name":"Trochanter","level":4,"score":0.4783862829208374},{"id":"https://openalex.org/C3018571302","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Postmenopausal osteoporosis","level":4,"score":0.4753282368183136},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.44809961318969727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4449719786643982},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.43113410472869873},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3386486768722534},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1948544979095459},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.06707856059074402},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.5799/ahinjs.01.2012.04.0202","doi":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","is_oa":true,"landing_page_url":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","pdf_url":"https://www.jceionline.org/download/the-effect-of-smoking-on-the-response-to-raloxifene-treatment-in-postmenopausal-osteoporosis-3372.pdf","source":{"id":"https://openalex.org/S2736377337","display_name":"Journal of Clinical and Experimental Investigations","issn_l":"1309-6621","issn":["1309-6621","1309-8578"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318340","host_organization_name":"Association of Health Investigations","host_organization_lineage":["https://openalex.org/P4310318340"],"host_organization_lineage_names":["Association of Health Investigations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Experimental Investigations","raw_type":"journal-article"},{"id":"pmh:8352e4bf-f8cc-4b66-b9eb-2ffa2ba44314","doi":null,"is_oa":false,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/8352e4bf-f8cc-4b66-b9eb-2ffa2ba44314/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.gov.tr:article/122345","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/jcei/issue/9895/122345","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 3, Issue: 4\\n 457-462\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/122345","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/jcei/issue/9895/122345","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Experimental Investigations","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:795fff22a1d94b89a2294b441bfac014","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/795fff22a1d94b89a2294b441bfac014","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Experimental Investigations, Vol 3, Iss 4, Pp 457-462 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5799/ahinjs.01.2012.04.0202","doi":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","is_oa":true,"landing_page_url":"https://doi.org/10.5799/ahinjs.01.2012.04.0202","pdf_url":"https://www.jceionline.org/download/the-effect-of-smoking-on-the-response-to-raloxifene-treatment-in-postmenopausal-osteoporosis-3372.pdf","source":{"id":"https://openalex.org/S2736377337","display_name":"Journal of Clinical and Experimental Investigations","issn_l":"1309-6621","issn":["1309-6621","1309-8578"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318340","host_organization_name":"Association of Health Investigations","host_organization_lineage":["https://openalex.org/P4310318340"],"host_organization_lineage_names":["Association of Health Investigations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Experimental Investigations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005175560.pdf","grobid_xml":"https://content.openalex.org/works/W2005175560.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1500655595","https://openalex.org/W1692547283","https://openalex.org/W1971909806","https://openalex.org/W1976389084","https://openalex.org/W1985985844","https://openalex.org/W1987640745","https://openalex.org/W2011714562","https://openalex.org/W2023387544","https://openalex.org/W2030140979","https://openalex.org/W2030584205","https://openalex.org/W2037186387","https://openalex.org/W2044494661","https://openalex.org/W2079121449","https://openalex.org/W2084377642","https://openalex.org/W2113958163","https://openalex.org/W2114045481","https://openalex.org/W2132164552","https://openalex.org/W2135116172","https://openalex.org/W2136298235","https://openalex.org/W2169664261","https://openalex.org/W2488643011","https://openalex.org/W3149849416","https://openalex.org/W4253002776","https://openalex.org/W4253861232"],"related_works":["https://openalex.org/W2185477915","https://openalex.org/W2084377642","https://openalex.org/W7098107986","https://openalex.org/W2086570453","https://openalex.org/W2390538124","https://openalex.org/W2049765534","https://openalex.org/W3090905828","https://openalex.org/W2358323640","https://openalex.org/W4299353235","https://openalex.org/W2352816967"],"abstract_inverted_index":{"Objectives:":[0],"The":[1,108,250],"aim":[2],"of":[3,11,16,73,77,177,198,202,253],"this":[4,26],"study":[5],"was":[6],"to":[7,46,162],"examine":[8],"the":[9,14,62,71,74,78,80,92,115,121,123,168,175,179,196,199,203,220,233,237,241],"effect":[10],"smoking":[12],"on":[13],"efficacy":[15,252],"raloxifene":[17,29,254],"treatment":[18,43,245,251],"in":[19,61,110,189,208,219,232,240,255,259],"postmenopausal":[20,63,144,260],"osteoporosis.":[21,69],"Materials":[22],"and":[23,33,65,99,104,157,211],"methods:":[24],"In":[25],"cross-sectional":[27],"study,":[28],"HCl":[30],"(60":[31],"mg/day)":[32],"600":[34],"mg":[35],"ionized":[36],"calcium":[37],"+":[38],"400":[39],"IU":[40],"vitamin":[41],"D/day":[42],"were":[44,60,86,106,112,160,182,213,228],"given":[45],"63":[47],"cases":[48],"(nonsmoker":[49],"group":[50,55,222,243],"n":[51,56],"=":[52,57],"39,":[53],"smoker":[54,242],"24),":[58],"who":[59],"period":[64],"detected":[66,214],"as":[67],"having":[68],"At":[70,174,195],"end":[72,197],"first":[75,200],"year":[76,201],"treatment,":[79,122,178,204],"bone":[81],"mineral":[82],"densities":[83],"(BMDs;":[84],"g/cm2)":[85],"measured":[87,187,217],"at":[88],"four":[89],"regions,":[90],"namely":[91],"femur":[93,95],"neck,":[94],"trochanter,":[96],"total":[97],"hip,":[98],"lumbar":[100],"vertebrae":[101],"between":[102,114,167],"L1-4,":[103],"T-scores":[105,212],"determined.":[107],"changes":[109],"BMDs":[111],"compared":[113],"two":[116,169],"groups.":[117],"Results:":[118],"Before":[119],"starting":[120],"mean":[124],"ages":[125,135],"(55.8":[126],"\u00b1":[127,131,137,141,147,151],"3.3":[128],"vs.":[129,139,149],"53.0":[130],"1.3":[132,148],"years),":[133,143,153],"menopausal":[134],"(49.3":[136],"2.9":[138],"48.1":[140],"2.1":[142],"periods":[145],"(5.0":[146],"7.0":[150],"1.4":[152],"body":[154],"mass":[155],"indexes,":[156],"estradiol":[158],"levels":[159],"found":[161],"be":[163],"significantly":[164],"not":[165,183],"different":[166,184],"groups":[170,191],"(p":[171,192,223,246],">":[172,193,247],"0.05).":[173,194,225,248],"beginning":[176],"BMD":[180,209,234,257],"values":[181,210,235,239,258],"for":[185,215],"all":[186,216],"regions":[188,218],"both":[190],"statistically":[205],"significant":[206,230],"improvements":[207],"nonsmoker":[221],"<":[224],"However,":[226],"there":[227],"no":[229],"differences":[231],"from":[236],"initial":[238],"after":[244],"Conclusions:":[249],"improving":[256],"osteoporosis":[261],"is":[262],"negatively":[263],"influenced":[264],"by":[265],"smoking.":[266],"J":[267]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}