{"id":"https://openalex.org/W2005167931","doi":"https://doi.org/10.1177/37.4.2926122","title":"Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves.","display_name":"Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves.","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W2005167931","doi":"https://doi.org/10.1177/37.4.2926122","mag":"2005167931","pmid":"https://pubmed.ncbi.nlm.nih.gov/2926122"},"language":"en","primary_location":{"id":"doi:10.1177/37.4.2926122","doi":"https://doi.org/10.1177/37.4.2926122","is_oa":true,"landing_page_url":"https://doi.org/10.1177/37.4.2926122","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/37.4.2926122?download=true","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/37.4.2926122?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085616164","display_name":"A Spreca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Spreca","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy","Dept of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Dept of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109141710","display_name":"Maria Grazia Rambotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M G Rambotti","raw_affiliation_strings":["Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","Section ofAnatomy ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Section ofAnatomy ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108196381","display_name":"Mario Rende","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Rende","raw_affiliation_strings":["Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","Section ofAnatomy ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Section ofAnatomy ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440695","display_name":"Carla Saccardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Saccardi","raw_affiliation_strings":["Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","Section ofAnatomy ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Section ofAnatomy ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069712145","display_name":"Maria Cristina Aisa","orcid":"https://orcid.org/0000-0002-8557-1253","observed_orcids":["https://orcid.org/0000-0002-8557-1253"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M C Aisa","raw_affiliation_strings":["Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","Section ofAnatomy ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofEvperimental Medicine and Biochemical Sciences , University ofPerugia , 06100 Perugia , Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Section ofAnatomy ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004248703","display_name":"Ileana Giambanco","orcid":"https://orcid.org/0000-0003-0286-6302","observed_orcids":["https://orcid.org/0000-0003-0286-6302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Giambanco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065739247","display_name":"Rosario Donato","orcid":"https://orcid.org/0000-0002-9608-4506","observed_orcids":["https://orcid.org/0000-0002-9608-4506","https://orcid.org/0000-0002-2001-6857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Donato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.6362,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.82771138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"4","first_page":"441","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100b-protein","display_name":"S100B protein","score":0.972000002861023},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nerve-crush-injury","display_name":"nerve crush injury","score":0.718999981880188},{"id":"https://openalex.org/keywords/nerve-transection","display_name":"nerve transection","score":0.9620000123977661},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7200000286102295},{"id":"https://openalex.org/keywords/distal-nerve-stump","display_name":"distal nerve stump","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.7360242605209351},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6816102266311646},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.6745609045028687},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6118776202201843},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.4974823296070099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49204227328300476},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4735671281814575},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4415878653526306},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4159505367279053},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4149879813194275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39775678515434265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3882621228694916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35739338397979736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20037898421287537}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064568","descriptor_name":"S100 Calcium Binding Protein beta Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/37.4.2926122","doi":"https://doi.org/10.1177/37.4.2926122","is_oa":true,"landing_page_url":"https://doi.org/10.1177/37.4.2926122","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/37.4.2926122?download=true","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},{"id":"pmid:2926122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2926122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/37.4.2926122","doi":"https://doi.org/10.1177/37.4.2926122","is_oa":true,"landing_page_url":"https://doi.org/10.1177/37.4.2926122","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/37.4.2926122?download=true","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005167931.pdf","grobid_xml":"https://content.openalex.org/works/W2005167931.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1504165580","https://openalex.org/W1521016570","https://openalex.org/W1965055828","https://openalex.org/W1965750292","https://openalex.org/W1973032540","https://openalex.org/W1991380950","https://openalex.org/W2006296875","https://openalex.org/W2037157916","https://openalex.org/W2055448106","https://openalex.org/W2072059063","https://openalex.org/W2091238338","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2132079448","https://openalex.org/W2132443705","https://openalex.org/W2137916391","https://openalex.org/W2163955917","https://openalex.org/W2171343703","https://openalex.org/W2172291684","https://openalex.org/W2401471167","https://openalex.org/W2883054000"],"related_works":["https://openalex.org/W2369028249","https://openalex.org/W2240104430","https://openalex.org/W2089985513","https://openalex.org/W2055618689","https://openalex.org/W2383226524","https://openalex.org/W1983794951","https://openalex.org/W2041043559","https://openalex.org/W1975499097","https://openalex.org/W2056611054","https://openalex.org/W2078804979"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,30,43,53,56,60,67,73,84,89,94,97,106,116,119,135,153,160,164,168,202,228,232,237,246,253,256],"cellular":[3],"and":[4,13,32,77,99,101,125,177,183,197,251],"subcellular":[5],"distribution":[6],"of":[7,34,96,118,138,170,201,204,211,216,236,240,248,260,267],"S-100b":[8,25,144],"protein":[9,26,145,206,218,234,258],"in":[10,42,46,62,78,93,115,123,134,152,159,207,219,231,255],"normal,":[11],"crushed,":[12],"transected":[14,139,241],"rat":[15],"sciatic":[16],"nerves":[17,242],"by":[18,175],"an":[19],"immunocytochemical":[20,223],"procedure.":[21],"In":[22],"uninjured":[23],"nerves,":[24],"was":[27],"restricted":[28],"to":[29,55,72,103,111,245,252,265],"cytoplasm":[31],"membranes":[33],"Schwann":[35,64,80,127,156,220,249],"cells,":[36,262],"with":[37],"no":[38,113],"reaction":[39,121,147],"product":[40,122,148],"present":[41,158],"nucleus":[44],"or":[45],"axons.":[47,268],"Similar":[48],"images":[49,131],"were":[50,132],"seen":[51,133],"from":[52],"first":[54],"thirtieth":[57],"day":[58],"after":[59,88],"crush":[61,98],"activated":[63,126,155],"cells":[65,81,157,179,250],"during":[66,83],"degeneration":[68,266],"period,":[69,86],"i.e.,":[70,87],"up":[71],"seventh":[74,90,165],"post-lesion":[75,91,166],"day,":[76,92,167],"normal":[79,124],"reappearing":[82],"regeneration":[85],"zone":[95],"proximal":[100,136],"distal":[102,161,238],"it.":[104],"By":[105,185],"technique":[107],"employed,":[108],"there":[109],"seemed":[110],"be":[112,150],"differences":[114],"intensity":[117],"immune":[120,146],"cells.":[128,221],"Also,":[129],"similar":[130,188],"stump":[137,162,239],"nerves.":[140],"Only":[141],"a":[142],"slight":[143],"could":[149],"observed":[151],"rare":[154],"around":[163],"majority":[169],"cell":[171],"types":[172],"being":[173],"represented":[174],"fibroblasts":[176],"elongated":[178],"at":[180],"this":[181],"stage":[182],"thereafter.":[184],"immunochemical":[186],"assays,":[187],"results":[189],"as":[190,199],"those":[191],"presented":[192],"here":[193],"have":[194],"been":[195],"reported":[196],"interpreted":[198],"indicative":[200],"presence":[203],"S-100":[205,217,233,257],"axons":[208],"or,":[209],"alternatively,":[210],"axonal":[212],"control":[213],"over":[214],"expression":[215],"Our":[222],"data":[224],"clearly":[225],"show":[226],"that":[227],"strong":[229],"reduction":[230],"content":[235,259],"is":[243],"owing":[244],"paucity":[247],"decrease":[254],"these":[261],"rather":[263],"than":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}