{"id":"https://openalex.org/W2005161436","doi":"https://doi.org/10.1002/mrd.21074","title":"Adverse effects associated with persistent stimulation of Leydig cells with hCG in vitro","display_name":"Adverse effects associated with persistent stimulation of Leydig cells with hCG in vitro","publication_year":2009,"publication_date":"2009-07-02","ids":{"openalex":"https://openalex.org/W2005161436","doi":"https://doi.org/10.1002/mrd.21074","mag":"2005161436","pmid":"https://pubmed.ncbi.nlm.nih.gov/19575391"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.21074","doi":"https://doi.org/10.1002/mrd.21074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.21074","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091643482","display_name":"Archana Aggarwal","orcid":"https://orcid.org/0000-0002-0098-7859","observed_orcids":["https://orcid.org/0000-0002-0098-7859","https://orcid.org/0000-0002-7382-8242"]},"institutions":[{"id":"https://openalex.org/I4210094607","display_name":"National Institute of Health and Family Welfare","ror":"https://ror.org/009ezqy65","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094607"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Archana Aggarwal","raw_affiliation_strings":["Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi 110067, India","Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, Baba Gang Nath Marg, New Delhi-110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210094607"]},{"raw_affiliation_string":"Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, Baba Gang Nath Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210094607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110119292","display_name":"Man Mohan Misro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094607","display_name":"National Institute of Health and Family Welfare","ror":"https://ror.org/009ezqy65","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094607"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Man M. Misro","raw_affiliation_strings":["Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210094607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027289068","display_name":"Ankur Maheshwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094607","display_name":"National Institute of Health and Family Welfare","ror":"https://ror.org/009ezqy65","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094607"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankur Maheshwari","raw_affiliation_strings":["Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210094607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018798317","display_name":"Neeta Sehgal","orcid":"https://orcid.org/0000-0001-8204-2279","observed_orcids":["https://orcid.org/0000-0001-8204-2279"]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeta Sehgal","raw_affiliation_strings":["Department of Zoology, University of Delhi, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Delhi, New Delhi, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102171236","display_name":"Deoki Nandan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094607","display_name":"National Institute of Health and Family Welfare","ror":"https://ror.org/009ezqy65","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094607"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deoki Nandan","raw_affiliation_strings":["Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, Baba Gang Nath Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210094607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110119292"],"corresponding_institution_ids":["https://openalex.org/I4210094607"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":3.4726,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.91203111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"11","first_page":"1076","last_page":"1083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.878000020980835},{"id":"https://openalex.org/keywords/fas-fasl-pathway","display_name":"Fas/FasL pathway","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.7369999885559082},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.875},{"id":"https://openalex.org/keywords/testicular-toxicity","display_name":"testicular toxicity","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.771203875541687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7629550099372864},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6461371183395386},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5953730940818787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5870773196220398},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5843496918678284},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5611835718154907},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5564238429069519},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.535876989364624},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.532941460609436},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.4576176702976227},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4308803677558899},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.42921698093414307},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.27007246017456055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1873675286769867},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15144094824790955},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.09689071774482727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0651598870754242}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.21074","doi":"https://doi.org/10.1002/mrd.21074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.21074","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:19575391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19575391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1535575443","https://openalex.org/W1581414347","https://openalex.org/W1587832347","https://openalex.org/W1745634660","https://openalex.org/W1925041868","https://openalex.org/W1963479720","https://openalex.org/W1964815632","https://openalex.org/W1983310681","https://openalex.org/W1985690685","https://openalex.org/W1995777493","https://openalex.org/W1997208169","https://openalex.org/W1999918617","https://openalex.org/W2000585388","https://openalex.org/W2003579383","https://openalex.org/W2004062071","https://openalex.org/W2020601518","https://openalex.org/W2024845699","https://openalex.org/W2038098721","https://openalex.org/W2039094079","https://openalex.org/W2041466047","https://openalex.org/W2051219590","https://openalex.org/W2053076131","https://openalex.org/W2053521180","https://openalex.org/W2067549655","https://openalex.org/W2075682488","https://openalex.org/W2084640849","https://openalex.org/W2087877138","https://openalex.org/W2103977809","https://openalex.org/W2114939021","https://openalex.org/W2161159096","https://openalex.org/W2168818408","https://openalex.org/W2494396193","https://openalex.org/W2499363915","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2557798099","https://openalex.org/W4306407686","https://openalex.org/W2072761542","https://openalex.org/W2201248234","https://openalex.org/W2009538055","https://openalex.org/W2074324989","https://openalex.org/W2081917043","https://openalex.org/W2412174172","https://openalex.org/W2025687052","https://openalex.org/W1953847668"],"abstract_inverted_index":{"The":[0],"detrimental":[1],"effects":[2,121],"of":[3,32,116],"persistent":[4,113],"stimulation":[5,115],"with":[6,26,81],"hCG":[7,54,114],"were":[8,48],"investigated":[9],"in":[10,14,18,29,60,74,84],"rat":[11],"Leydig":[12,117],"cells":[13,63,118],"vitro.":[15],"Significant":[16],"rise":[17,83],"lipid":[19],"peroxidation":[20],"and":[21,38,45,89,96,126],"reactive":[22],"oxygen":[23],"species":[24],"(ROS)":[25],"concomitant":[27],"attenuation":[28],"the":[30,56,61,108,133],"activities":[31],"antioxidant":[33,58],"enzymes:":[34],"superoxide":[35,46],"dismutase,":[36],"catalase,":[37],"glutathione-S-transferase":[39],"was":[40,71,79,129],"observed.":[41],"Transcripts":[42],"for":[43],"catalase":[44],"dismutase":[47],"also":[49,64],"depleted.":[50],"Subsequent":[51],"to":[52,123],"each":[53],"challenge,":[55],"total":[57],"capacity":[59],"target":[62],"declined":[65],"significantly":[66],"(P":[67],"<":[68],"0.05).":[69],"There":[70],"an":[72],"increase":[73],"cell":[75],"apoptosis":[76,127],"(23%),":[77],"which":[78,128],"associated":[80],"a":[82,103],"caspase-3":[85],"activity,":[86],"PARP":[87],"cleavage,":[88],"Fas,":[90],"FasL,":[91],"caspase-8":[92],"expression.":[93],"While":[94],"Bax":[95],"Caspase-9":[97],"expression":[98],"remained":[99],"unchanged,":[100],"Bcl-2":[101],"demonstrated":[102],"marked":[104],"decline.":[105],"Taken":[106],"together,":[107],"above":[109],"data":[110],"indicate":[111],"that":[112],"induced":[119],"adverse":[120],"leading":[122],"oxidative":[124],"stress":[125],"channeled":[130],"primarily":[131],"through":[132],"extrinsic":[134],"pathway.":[135]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}