{"id":"https://openalex.org/W2005159602","doi":"https://doi.org/10.1016/j.bbapap.2014.12.004","title":"Resolution of sub-nanosecond motions in botulinum neurotoxin endopeptidase: An evidence of internal flexibility","display_name":"Resolution of sub-nanosecond motions in botulinum neurotoxin endopeptidase: An evidence of internal flexibility","publication_year":2015,"publication_date":"2015-01-09","ids":{"openalex":"https://openalex.org/W2005159602","doi":"https://doi.org/10.1016/j.bbapap.2014.12.004","mag":"2005159602","pmid":"https://pubmed.ncbi.nlm.nih.gov/25578806"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbapap.2014.12.004","doi":"https://doi.org/10.1016/j.bbapap.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007780827","display_name":"Raj Kumar","orcid":"https://orcid.org/0000-0003-2328-8521","observed_orcids":["https://orcid.org/0000-0003-2328-8521","https://orcid.org/0000-0001-7479-696X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Kumar","raw_affiliation_strings":["Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079079484","display_name":"Shuowei Cai","orcid":"https://orcid.org/0000-0003-4293-332X","observed_orcids":["https://orcid.org/0000-0003-4293-332X"]},"institutions":[{"id":"https://openalex.org/I100633361","display_name":"University of Massachusetts Dartmouth","ror":"https://ror.org/00fzmm222","country_code":"US","type":"education","lineage":["https://openalex.org/I100633361"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuowei Cai","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747, USA","institution_ids":["https://openalex.org/I100633361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064626318","display_name":"Emmanuel C. A. Ojadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100633361","display_name":"University of Massachusetts Dartmouth","ror":"https://ror.org/00fzmm222","country_code":"US","type":"education","lineage":["https://openalex.org/I100633361"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Ojadi","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747, USA","institution_ids":["https://openalex.org/I100633361"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083903249","display_name":"Bal Ram Singh","orcid":"https://orcid.org/0000-0002-9069-1487","observed_orcids":["https://orcid.org/0000-0002-9069-1487"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bal. R. Singh","raw_affiliation_strings":["Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083903249"],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.2163,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55715658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"1854","issue":"5","first_page":"321","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.22190000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-neurotoxin-a","display_name":"botulinum neurotoxin A","score":0.9049999713897705},{"id":"https://openalex.org/keywords/light-chain","display_name":"light chain","score":0.75},{"id":"https://openalex.org/keywords/internal-flexibility","display_name":"internal flexibility","score":0.7879999876022339},{"id":"https://openalex.org/keywords/rotational-correlation-time","display_name":"rotational correlation time","score":0.949999988079071},{"id":"https://openalex.org/keywords/viscosity-dependence","display_name":"viscosity dependence","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fluorescence-anisotropy-decay","display_name":"fluorescence anisotropy decay","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protein-dynamics-in-solution","display_name":"protein dynamics in solution","score":0.7770000100135803},{"id":"https://openalex.org/keywords/endopeptidase","display_name":"endopeptidase","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C111357860","wikidata":"https://www.wikidata.org/wiki/Q903807","display_name":"Fluorescence anisotropy","level":3,"score":0.6775404810905457},{"id":"https://openalex.org/C51141536","wikidata":"https://www.wikidata.org/wiki/Q838801","display_name":"Nanosecond","level":3,"score":0.6440958976745605},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5905142426490784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.545522153377533},{"id":"https://openalex.org/C85725439","wikidata":"https://www.wikidata.org/wiki/Q466686","display_name":"Anisotropy","level":2,"score":0.5172341465950012},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4768998622894287},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.44501200318336487},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.43882253766059875},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.387167751789093},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3869677186012268},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.38485008478164673},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3431605100631714},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31006038188934326},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1774972379207611},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17173242568969727},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.1583210825920105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14680752158164978},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1015298068523407},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012399","descriptor_name":"Rotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbapap.2014.12.004","doi":"https://doi.org/10.1016/j.bbapap.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},{"id":"pmid:25578806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25578806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8096748079","display_name":null,"funder_award_id":"1U01A1078070-01","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1571199640","https://openalex.org/W1967047911","https://openalex.org/W1974824041","https://openalex.org/W1978793878","https://openalex.org/W1989165179","https://openalex.org/W1998965573","https://openalex.org/W2000967260","https://openalex.org/W2003276245","https://openalex.org/W2005531630","https://openalex.org/W2011247224","https://openalex.org/W2012239955","https://openalex.org/W2014896559","https://openalex.org/W2022104280","https://openalex.org/W2023256861","https://openalex.org/W2025658717","https://openalex.org/W2035472706","https://openalex.org/W2041619027","https://openalex.org/W2053901147","https://openalex.org/W2055942417","https://openalex.org/W2061576548","https://openalex.org/W2062625440","https://openalex.org/W2067500833","https://openalex.org/W2079868528","https://openalex.org/W2087976194","https://openalex.org/W2091361840","https://openalex.org/W2101995406","https://openalex.org/W2103403086","https://openalex.org/W2129974957","https://openalex.org/W2140866248","https://openalex.org/W2161374457","https://openalex.org/W2344070809"],"related_works":["https://openalex.org/W2805098541","https://openalex.org/W7205541662","https://openalex.org/W1980598644","https://openalex.org/W2032686956","https://openalex.org/W2023256861","https://openalex.org/W1994111783","https://openalex.org/W2060143266","https://openalex.org/W2467188094","https://openalex.org/W4401504017","https://openalex.org/W2028996235"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
