{"id":"https://openalex.org/W2005159406","doi":"https://doi.org/10.1016/j.jconrel.2014.10.024","title":"Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: Probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation","display_name":"Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: Probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation","publication_year":2014,"publication_date":"2014-11-04","ids":{"openalex":"https://openalex.org/W2005159406","doi":"https://doi.org/10.1016/j.jconrel.2014.10.024","mag":"2005159406","pmid":"https://pubmed.ncbi.nlm.nih.gov/25449802"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2014.10.024","doi":"https://doi.org/10.1016/j.jconrel.2014.10.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.10.024","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101607250","display_name":"Xiaopeng Han","orcid":"https://orcid.org/0000-0001-8676-8579","observed_orcids":["https://orcid.org/0000-0001-8676-8579"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaopeng Han","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101417761","display_name":"Zhenbao Li","orcid":"https://orcid.org/0000-0002-9751-2170","observed_orcids":["https://orcid.org/0000-0002-9751-2170"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenbao Li","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019330832","display_name":"Jin Sun","orcid":"https://orcid.org/0000-0001-5470-1599","observed_orcids":["https://orcid.org/0000-0001-5470-1599","https://orcid.org/0000-0002-7494-3963"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Sun","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China; Municipal key laboratory of biopharmacetics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: sunjin66@21cn.com","Municipal key laboratory of biopharmacetics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China; Municipal key laboratory of biopharmacetics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: sunjin66@21cn.com","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Municipal key laboratory of biopharmacetics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005186305","display_name":"Cong Luo","orcid":"https://orcid.org/0000-0002-0506-9598","observed_orcids":["https://orcid.org/0000-0002-0506-9598"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Luo","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412926","display_name":"Lin Li","orcid":"https://orcid.org/0000-0003-0426-6546","observed_orcids":["https://orcid.org/0000-0003-0426-6546","https://orcid.org/0009-0006-4540-8271","https://orcid.org/0000-0001-7240-8150","https://orcid.org/0000-0002-8256-5333"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045317631","display_name":"Yuhai Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhai Liu","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054393667","display_name":"Yuqian Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqian Du","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003963996","display_name":"Shuhong Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhong Qiu","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011344704","display_name":"Xiaoyu Ai","orcid":"https://orcid.org/0000-0003-3113-0118","observed_orcids":["https://orcid.org/0000-0003-3113-0118"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Ai","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032142693","display_name":"Chunnuan Wu","orcid":"https://orcid.org/0009-0001-8196-4463","observed_orcids":["https://orcid.org/0009-0001-8196-4463"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunnuan Wu","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002695281","display_name":"He Lian","orcid":"https://orcid.org/0000-0002-2815-1922","observed_orcids":["https://orcid.org/0000-0002-2815-1922"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Lian","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100420129","display_name":"Zhonggui He","orcid":"https://orcid.org/0000-0002-5907-3875","observed_orcids":["https://orcid.org/0000-0002-5907-3875","https://orcid.org/0000-0003-4536-0731","https://orcid.org/0000-0002-4172-7527"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhonggui He","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: hezhonggui@vip.163.com","School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China"],"raw_orcid":"https://orcid.org/0000-0003-4536-0731","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: hezhonggui@vip.163.com","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019330832","https://openalex.org/A5100420129"],"corresponding_institution_ids":["https://openalex.org/I103890011"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":5.8363,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.97514451,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"197","issue":null,"first_page":"29","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cd44-targeting","display_name":"CD44 targeting","score":0.8450000286102295},{"id":"https://openalex.org/keywords/doxorubicin-delivery","display_name":"doxorubicin delivery","score":0.8569999933242798},{"id":"https://openalex.org/keywords/stealth-nanoparticles","display_name":"stealth nanoparticles","score":0.7239999771118164},{"id":"https://openalex.org/keywords/supramolecular-nanoassemblies","display_name":"supramolecular nanoassemblies","score":0.843999981880188},{"id":"https://openalex.org/keywords/host-guest-interactions","display_name":"host-guest interactions","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hydroxypropyl-beta-cyclodextrin","display_name":"hydroxypropyl-\u03b2-cyclodextrin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vitamin-e-succinate","display_name":"vitamin E succinate","score":0.8379999995231628},{"id":"https://openalex.org/keywords/blood-circulation-time","display_name":"blood circulation time","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-biodistribution","display_name":"tumor biodistribution","score":0.9369999766349792},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.904144287109375},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.7166779637336731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6939847469329834},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6471003293991089},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5780023336410522},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.548566997051239},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.528126060962677},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5009646415710449},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4537196755409241},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.4505692720413208},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.44423016905784607},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.364335298538208},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33023154735565186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3079603314399719},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20105311274528503},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1919107735157013},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13997769355773926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07930797338485718},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073738","descriptor_name":"2-Hydroxypropyl-beta-cyclodextrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073738","descriptor_name":"2-Hydroxypropyl-beta-cyclodextrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073738","descriptor_name":"2-Hydroxypropyl-beta-cyclodextrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jconrel.2014.10.024","doi":"https://doi.org/10.1016/j.jconrel.2014.10.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.10.024","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25449802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25449802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2242190681","display_name":null,"funder_award_id":"81173008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5265633189","display_name":null,"funder_award_id":"NCET-12-1015","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G7368238135","display_name":null,"funder_award_id":"81373336","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7417080214","display_name":"\u514b\u670d\u80bf\u7624\u6e17\u900f\u9650\u5236\u7684\u591a\u9636\u6bb5\u7eb3\u7c73\u8f7d\u4f53\u7cfb\u7edf\u7684\u7814\u7a76","funder_award_id":"81273450","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1529170481","https://openalex.org/W1964424486","https://openalex.org/W1968656979","https://openalex.org/W1968866426","https://openalex.org/W1970535740","https://openalex.org/W1973345865","https://openalex.org/W1974994114","https://openalex.org/W1975912702","https://openalex.org/W1978165313","https://openalex.org/W1978486312","https://openalex.org/W1979059415","https://openalex.org/W1985241728","https://openalex.org/W1985657936","https://openalex.org/W1987960919","https://openalex.org/W1995690527","https://openalex.org/W1996585845","https://openalex.org/W1998268788","https://openalex.org/W2003090882","https://openalex.org/W2004680537","https://openalex.org/W2007347651","https://openalex.org/W2009805582","https://openalex.org/W2012727362","https://openalex.org/W2018638665","https://openalex.org/W2018898714","https://openalex.org/W2020623713","https://openalex.org/W2022645876","https://openalex.org/W2023389405","https://openalex.org/W2029839190","https://openalex.org/W2030389019","https://openalex.org/W2038626534","https://openalex.org/W2042949277","https://openalex.org/W2046070477","https://openalex.org/W2053515735","https://openalex.org/W2054432852","https://openalex.org/W2056493684","https://openalex.org/W2067392670","https://openalex.org/W2069374586","https://openalex.org/W2075204828","https://openalex.org/W2076613720","https://openalex.org/W2081743184","https://openalex.org/W2086393160","https://openalex.org/W2088070731","https://openalex.org/W2089987199","https://openalex.org/W2090237658","https://openalex.org/W2092969862","https://openalex.org/W2096662766","https://openalex.org/W2099204819","https://openalex.org/W2103914087","https://openalex.org/W2104993716","https://openalex.org/W2105666528","https://openalex.org/W2106926141","https://openalex.org/W2122442539","https://openalex.org/W2132717713","https://openalex.org/W2132722996","https://openalex.org/W2139274035","https://openalex.org/W2145479354","https://openalex.org/W2151091220","https://openalex.org/W2161622566","https://openalex.org/W2166699632","https://openalex.org/W2321481286","https://openalex.org/W2328876258","https://openalex.org/W4238726741","https://openalex.org/W4244618912","https://openalex.org/W6631777726","https://openalex.org/W6684559784"],"related_works":["https://openalex.org/W2069387121","https://openalex.org/W3087396862","https://openalex.org/W3109480263","https://openalex.org/W2146029618","https://openalex.org/W2581873068","https://openalex.org/W2944031322","https://openalex.org/W2009938139","https://openalex.org/W1876583446","https://openalex.org/W3110044381","https://openalex.org/W2246230450"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":11}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}