{"id":"https://openalex.org/W2005157820","doi":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","title":"Inherited Thrombophilia and IVF Failure: The Impact of Coagulation Disorders On Implantation Process","display_name":"Inherited Thrombophilia and IVF Failure: The Impact of Coagulation Disorders On Implantation Process","publication_year":2012,"publication_date":"2012-05-24","ids":{"openalex":"https://openalex.org/W2005157820","doi":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","mag":"2005157820","pmid":"https://pubmed.ncbi.nlm.nih.gov/22620672"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0897.2012.01156.x","doi":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005157820"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033807588","display_name":"P Ivanov","orcid":"https://orcid.org/0000-0002-7754-9128","observed_orcids":["https://orcid.org/0000-0002-7754-9128"]},"institutions":[{"id":"https://openalex.org/I507746717","display_name":"Medical University Pleven","ror":"https://ror.org/049ztct72","country_code":"BG","type":"education","lineage":["https://openalex.org/I507746717"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Petar Ivanov","raw_affiliation_strings":["Clinical Institute for Reproductive Medicine, Pleven, Bulgaria","Department of Biochemistry, Medical University, Pleven, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Institute for Reproductive Medicine, Pleven, Bulgaria","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical University, Pleven, Bulgaria","institution_ids":["https://openalex.org/I507746717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042424298","display_name":"Tsvetomira M. Tsvyatkovska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsvetomira Tsvyatkovska","raw_affiliation_strings":["Clinical Institute for Reproductive Medicine, Pleven, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Institute for Reproductive Medicine, Pleven, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026637776","display_name":"Emiliana Ilieva Konova","orcid":"https://orcid.org/0000-0002-7329-1975","observed_orcids":["https://orcid.org/0000-0002-7329-1975"]},"institutions":[{"id":"https://openalex.org/I507746717","display_name":"Medical University Pleven","ror":"https://ror.org/049ztct72","country_code":"BG","type":"education","lineage":["https://openalex.org/I507746717"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Emiliana Konova","raw_affiliation_strings":["Center of Clinical Immunology, University Hospital, Pleven, Bulgaria","Clinical Institute for Reproductive Medicine, Pleven, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Clinical Immunology, University Hospital, Pleven, Bulgaria","institution_ids":["https://openalex.org/I507746717"]},{"raw_affiliation_string":"Clinical Institute for Reproductive Medicine, Pleven, Bulgaria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083265925","display_name":"Regina Komsa\u2010Penkova","orcid":"https://orcid.org/0000-0002-1349-9555","observed_orcids":["https://orcid.org/0000-0002-1349-9555"]},"institutions":[{"id":"https://openalex.org/I507746717","display_name":"Medical University Pleven","ror":"https://ror.org/049ztct72","country_code":"BG","type":"education","lineage":["https://openalex.org/I507746717"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Regina Komsa\u2010Penkova","raw_affiliation_strings":["Department of Biochemistry, Medical University, Pleven, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical University, Pleven, Bulgaria","institution_ids":["https://openalex.org/I507746717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033807588"],"corresponding_institution_ids":["https://openalex.org/I507746717"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":null,"fwci":0.1527,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.1013986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"3","first_page":"189","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inherited-thrombophilia","display_name":"inherited thrombophilia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/in-vitro-fertilization-failure","display_name":"in vitro fertilization failure","score":0.8769999742507935},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.972000002861023},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9829999804496765},{"id":"https://openalex.org/keywords/prothrombin","display_name":"prothrombin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/factor-v","display_name":"factor V","score":0.9210000038146973},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8230000138282776},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.6326796412467957},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.5807486772537231},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5057435035705566},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4849534332752228},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4585314989089966},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.45087385177612305},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4460695683956146},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.415240615606308},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.41303592920303345},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.41199013590812683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4110109210014343},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3951469361782074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.372119665145874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3718665540218353},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35654643177986145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2911207675933838},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.21967211365699768},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.1320558488368988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10244289040565491},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.09922027587890625}],"mesh":[{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D040201","descriptor_name":"Platelet Membrane Glycoprotein IIb","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0897.2012.01156.x","doi":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0897.2012.01156.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},{"id":"pmid:22620672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22620672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of reproductive immunology (New York, N.Y. : 1989)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W12296215","https://openalex.org/W67858305","https://openalex.org/W1482397881","https://openalex.org/W1524603322","https://openalex.org/W1528774866","https://openalex.org/W1531281563","https://openalex.org/W1533917965","https://openalex.org/W1578928532","https://openalex.org/W1594582681","https://openalex.org/W1833068323","https://openalex.org/W1965430426","https://openalex.org/W1969431157","https://openalex.org/W1970051571","https://openalex.org/W1970620280","https://openalex.org/W1970837032","https://openalex.org/W1972058538","https://openalex.org/W1975932625","https://openalex.org/W1983334409","https://openalex.org/W1986624029","https://openalex.org/W1988933424","https://openalex.org/W1989800882","https://openalex.org/W1991281779","https://openalex.org/W1992651294","https://openalex.org/W1994167394","https://openalex.org/W2002455317","https://openalex.org/W2013477612","https://openalex.org/W2021642676","https://openalex.org/W2022956316","https://openalex.org/W2024109963","https://openalex.org/W2024314380","https://openalex.org/W2027494534","https://openalex.org/W2031528961","https://openalex.org/W2038414684","https://openalex.org/W2038449831","https://openalex.org/W2039375931","https://openalex.org/W2046103305","https://openalex.org/W2052494211","https://openalex.org/W2058018180","https://openalex.org/W2061689857","https://openalex.org/W2072278671","https://openalex.org/W2074892672","https://openalex.org/W2074919653","https://openalex.org/W2079964515","https://openalex.org/W2081413967","https://openalex.org/W2088661170","https://openalex.org/W2090822458","https://openalex.org/W2092565468","https://openalex.org/W2094505351","https://openalex.org/W2102432290","https://openalex.org/W2104062454","https://openalex.org/W2107970325","https://openalex.org/W2108706048","https://openalex.org/W2109986779","https://openalex.org/W2112493515","https://openalex.org/W2113320969","https://openalex.org/W2117814062","https://openalex.org/W2120678843","https://openalex.org/W2121067875","https://openalex.org/W2125909495","https://openalex.org/W2126049594","https://openalex.org/W2127153432","https://openalex.org/W2131250377","https://openalex.org/W2131426352","https://openalex.org/W2134982308","https://openalex.org/W2140345134","https://openalex.org/W2141802887","https://openalex.org/W2144338232","https://openalex.org/W2144673545","https://openalex.org/W2144891453","https://openalex.org/W2149601349","https://openalex.org/W2150122989","https://openalex.org/W2152719935","https://openalex.org/W2153163550","https://openalex.org/W2160379290","https://openalex.org/W2162690063","https://openalex.org/W2163768600","https://openalex.org/W2164673344","https://openalex.org/W2167222851","https://openalex.org/W2270224123","https://openalex.org/W2319182210","https://openalex.org/W2320228255","https://openalex.org/W2326727601","https://openalex.org/W2338800987","https://openalex.org/W2418859793","https://openalex.org/W2431824564","https://openalex.org/W2461601511","https://openalex.org/W2883545750","https://openalex.org/W4324262439","https://openalex.org/W4327849098"],"related_works":["https://openalex.org/W2598947534","https://openalex.org/W2326727601","https://openalex.org/W2945709107","https://openalex.org/W4317495530","https://openalex.org/W2781656498","https://openalex.org/W2134805684","https://openalex.org/W4254347686","https://openalex.org/W1599411984","https://openalex.org/W2117924892","https://openalex.org/W1977471395"],"abstract_inverted_index":{"In":[0],"connection":[1],"with":[2,82,184],"the":[3,39,48,63,66,71,110,138,156,165,176],"embryo":[4,101,168,188],"acceptance":[5],"process":[6],"after":[7,170],"IVF":[8],"procedure,":[9],"endometrial":[10],"cells":[11,96],"surface":[12,57],"receptors,":[13],"extracellular":[14],"matrix":[15],"(ECM)":[16],"molecules,":[17],"endothelium":[18],"and":[19,46,94,97,116,122],"blood":[20],"circulation":[21],"factors":[22,125],"were":[23],"involved":[24],"in":[25,182],"remodelling":[26,45],"of":[27,42,65,78,112,140,155,161,167,178,186],"endometrium.":[28],"Plasminogen":[29],"activator":[30],"inhibitor":[31],"type":[32],"1":[33],"plays":[34],"a":[35,89],"significant":[36],"role":[37,111,118],"during":[38],"early":[40,187],"phases":[41],"placental":[43],"vascular":[44,102],"regulates":[47],"trophoblast":[49],"invasion":[50],"through":[51],"controlling":[52],"plasmin":[53],"activity.":[54,134],"Endometrial":[55],"cell":[56],"protein":[58],"integrin":[59,79],"alphaV/beta3,":[60],"responsible":[61],"for":[62,119],"adhesion":[64],"embryo,":[67],"has":[68,87],"had":[69,88],"also":[70],"same":[72],"subunit":[73],"beta3,":[74],"which":[75,147],"is":[76,148],"component":[77],"alphaIIb/beta3":[80],"connected":[81],"platelet":[83],"aggregability.":[84],"Prothrombin,":[85],"furthermore,":[86],"debatable":[90],"effect":[91,139],"upon":[92],"endothelial":[93],"mesenchymal":[95],"possible":[98],"contribution":[99],"on":[100,144,164],"development.":[103],"Confoundable":[104],"data":[105],"have":[106,126],"been":[107],"present":[108],"about":[109],"coagulation":[113,124,142],"factor":[114],"V":[115],"its":[117],"implantation.":[120],"These":[121],"other":[123],"relatively":[127],"common":[128],"gene":[129],"polymorphisms":[130],"that":[131],"enhanced":[132],"their":[133],"This":[135],"review":[136],"discusses":[137],"increased":[141],"activity":[143],"implantation":[145,169],"process,":[146],"not":[149],"yet":[150],"fully":[151],"determined.":[152],"The":[153],"establishment":[154],"positive":[157],"or":[158],"negative":[159],"impact":[160],"mother":[162],"hypercoagulability":[163],"success":[166],"assisted":[171],"reproduction":[172],"technology":[173],"could":[174],"determine":[175],"timing":[177],"preventing":[179],"anticoagulant":[180],"therapy":[181],"women":[183],"history":[185],"loss.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}