{"id":"https://openalex.org/W2005157401","doi":"https://doi.org/10.1111/odi.12036","title":"Association of CD 28 and CTLA \u20104 gene polymorphisms with aggressive periodontitis in Brazilians","display_name":"Association of CD 28 and CTLA \u20104 gene polymorphisms with aggressive periodontitis in Brazilians","publication_year":2012,"publication_date":"2012-10-18","ids":{"openalex":"https://openalex.org/W2005157401","doi":"https://doi.org/10.1111/odi.12036","mag":"2005157401","pmid":"https://pubmed.ncbi.nlm.nih.gov/23163888"},"language":"en","primary_location":{"id":"doi:10.1111/odi.12036","doi":"https://doi.org/10.1111/odi.12036","is_oa":true,"landing_page_url":"https://doi.org/10.1111/odi.12036","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/odi.12036","source":{"id":"https://openalex.org/S144270092","display_name":"Oral Diseases","issn_l":"1354-523X","issn":["1354-523X","1601-0825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/odi.12036","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034606662","display_name":"MRMA e Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"MRMA e Silva","raw_affiliation_strings":["Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042009928","display_name":"Paula Rocha Moreira","orcid":"https://orcid.org/0000-0003-1078-6281","observed_orcids":["https://orcid.org/0000-0003-1078-6281"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"PR Moreira","raw_affiliation_strings":["Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016038496","display_name":"GC da Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"GC da Costa","raw_affiliation_strings":["Universidade Federal de Vi\u00e7osa Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Vi\u00e7osa Belo Horizonte Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028829697","display_name":"AM Saraiva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"AM Saraiva","raw_affiliation_strings":["Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110561948","display_name":"PEA de Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170935008","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais","ror":"https://ror.org/03j1rr444","country_code":"BR","type":"education","lineage":["https://openalex.org/I170935008"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"PEA de Souza","raw_affiliation_strings":["Department of Pathology Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais Belo Horizonte Brazil","institution_ids":["https://openalex.org/I170935008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045938246","display_name":"SAF Amormino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"SAF Amormino","raw_affiliation_strings":["Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033500005","display_name":"JE da Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"JE da Costa","raw_affiliation_strings":["Department of Clinical, Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical, Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017399345","display_name":"Kenneth J. Gollob","orcid":"https://orcid.org/0000-0003-4184-3867","observed_orcids":["https://orcid.org/0000-0003-4184-3867"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]},{"id":"https://openalex.org/I2800505568","display_name":"Santa Casa Hospital","ror":"https://ror.org/01by1qv45","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800505568"]},{"id":"https://openalex.org/I4210090178","display_name":"Instituto de Ensino e Pesquisa Santa Casa","ror":"https://ror.org/0093zaj76","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210090178"]},{"id":"https://openalex.org/I4210151028","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126","country_code":"BR","type":"facility","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210127675","https://openalex.org/I4210151028","https://openalex.org/I4210151455"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"KJ Gollob","raw_affiliation_strings":["Institute for Education and Research, Santa Casa Hospital, Belo Horizonte, Brazil","National Institutes of Science and Technology, Tropical Diseases, INCT-DT, Belo Horizonte, MG, Brazil","Tropical Diseases Research Program, Center for Infections Disease Research, Biosciences Division, SRI International, Melo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Education and Research, Santa Casa Hospital, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I2800505568","https://openalex.org/I4210090178"]},{"raw_affiliation_string":"National Institutes of Science and Technology, Tropical Diseases, INCT-DT, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210151028"]},{"raw_affiliation_string":"Tropical Diseases Research Program, Center for Infections Disease Research, Biosciences Division, SRI International, Melo Park, CA, USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103554755","display_name":"WO Dutra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]},{"id":"https://openalex.org/I4210151028","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126","country_code":"BR","type":"facility","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210127675","https://openalex.org/I4210151028","https://openalex.org/I4210151455"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"WO Dutra","raw_affiliation_strings":["Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","National Institutes of Science and Technology, Tropical Diseases, INCT-DT, Belo Horizonte, MG, Brazil","Tropical Diseases Research Program, Center for Infections Disease Research, Biosciences Division, SRI International, Melo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell-Cell Interactions, Department of Morphology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"National Institutes of Science and Technology, Tropical Diseases, INCT-DT, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210151028"]},{"raw_affiliation_string":"Tropical Diseases Research Program, Center for Infections Disease Research, Biosciences Division, SRI International, Melo Park, CA, USA","institution_ids":["https://openalex.org/I1298353152"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5103554755"],"corresponding_institution_ids":["https://openalex.org/I110200422","https://openalex.org/I1298353152","https://openalex.org/I4210151028"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.7691,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72939856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"6","first_page":"568","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.746999979019165},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9210000038146973},{"id":"https://openalex.org/keywords/aggressive-periodontitis","display_name":"aggressive periodontitis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8830000162124634},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.9160000085830688},{"id":"https://openalex.org/keywords/clinical-attachment-loss","display_name":"clinical attachment loss","score":0.968999981880188},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.40299999713897705},{"id":"https://openalex.org/keywords/brazilian-population","display_name":"Brazilian population","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2778883934","wikidata":"https://www.wikidata.org/wiki/Q4692285","display_name":"Aggressive periodontitis","level":3,"score":0.8638510704040527},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.797798752784729},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.790075421333313},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7891380190849304},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.7131160497665405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5739724636077881},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.48337382078170776},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.419176310300827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4112369418144226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38512080907821655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38461214303970337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3803401589393616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23814073204994202}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010514","descriptor_name":"Periodontal Pocket","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010514","descriptor_name":"Periodontal Pocket","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017622","descriptor_name":"Periodontal Attachment Loss","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017622","descriptor_name":"Periodontal Attachment Loss","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055113","descriptor_name":"Chronic Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055113","descriptor_name":"Chronic Periodontitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/odi.12036","doi":"https://doi.org/10.1111/odi.12036","is_oa":true,"landing_page_url":"https://doi.org/10.1111/odi.12036","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/odi.12036","source":{"id":"https://openalex.org/S144270092","display_name":"Oral Diseases","issn_l":"1354-523X","issn":["1354-523X","1601-0825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Diseases","raw_type":"journal-article"},{"id":"pmid:23163888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23163888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/odi.12036","doi":"https://doi.org/10.1111/odi.12036","is_oa":true,"landing_page_url":"https://doi.org/10.1111/odi.12036","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/odi.12036","source":{"id":"https://openalex.org/S144270092","display_name":"Oral Diseases","issn_l":"1354-523X","issn":["1354-523X","1601-0825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320324025","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005157401.pdf","grobid_xml":"https://content.openalex.org/works/W2005157401.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1514518669","https://openalex.org/W1516219977","https://openalex.org/W1963831247","https://openalex.org/W1968335032","https://openalex.org/W1972400577","https://openalex.org/W1979641057","https://openalex.org/W1982375984","https://openalex.org/W1985539183","https://openalex.org/W1989282072","https://openalex.org/W2002241261","https://openalex.org/W2003979612","https://openalex.org/W2007311074","https://openalex.org/W2009963809","https://openalex.org/W2011412954","https://openalex.org/W2013368955","https://openalex.org/W2016918716","https://openalex.org/W2025776692","https://openalex.org/W2028635293","https://openalex.org/W2035011579","https://openalex.org/W2037368784","https://openalex.org/W2045457499","https://openalex.org/W2048447567","https://openalex.org/W2049299404","https://openalex.org/W2049760701","https://openalex.org/W2050316407","https://openalex.org/W2055248228","https://openalex.org/W2058779497","https://openalex.org/W2062329960","https://openalex.org/W2065899910","https://openalex.org/W2068525568","https://openalex.org/W2070023442","https://openalex.org/W2073206252","https://openalex.org/W2073406924","https://openalex.org/W2075462468","https://openalex.org/W2081590238","https://openalex.org/W2088313410","https://openalex.org/W2088427652","https://openalex.org/W2092540571","https://openalex.org/W2099107920","https://openalex.org/W2110760852","https://openalex.org/W2111665287","https://openalex.org/W2121078978","https://openalex.org/W2122264770","https://openalex.org/W2127110298","https://openalex.org/W2130445686","https://openalex.org/W2134927256","https://openalex.org/W2137290698","https://openalex.org/W2140029097","https://openalex.org/W2144261282","https://openalex.org/W2153426201","https://openalex.org/W2157430994","https://openalex.org/W2162530578","https://openalex.org/W2162540156","https://openalex.org/W2164405794","https://openalex.org/W2166229810","https://openalex.org/W2166300495","https://openalex.org/W2174784305","https://openalex.org/W4231975303"],"related_works":["https://openalex.org/W2075462468","https://openalex.org/W2898462291","https://openalex.org/W1979025432","https://openalex.org/W2104544944","https://openalex.org/W3043593279","https://openalex.org/W2971478181","https://openalex.org/W2979324966","https://openalex.org/W1997907114","https://openalex.org/W3047310949","https://openalex.org/W2595044991"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Susceptibility":[1],"to":[2,14,56,188],"and":[3,23,64,70,94,104,132,176],"severity":[4],"of":[5,30,52,84,128,203],"periodontal":[6,190],"disease":[7],"is":[8,35],"influenced":[9],"by":[10,112],"gene":[11,68],"polymorphisms":[12,37,69,197],"related":[13],"the":[15,28,53,58,125,129,139,177],"immune":[16],"response.":[17],"Co-stimulatory":[18],"molecules,":[19],"such":[20,31,100],"as":[21,101,198],"CD28":[22,63,130,172],"CTLA-4,":[24],"are":[25,184],"critical":[26],"in":[27,38,72,151,171,179,205],"development":[29],"responses.":[32],"Our":[33],"hypothesis":[34],"that":[36,40,169],"genes":[39],"code":[41],"for":[42,142],"these":[43,196],"molecules":[44],"may":[45],"be":[46],"associated":[47,145,185],"with":[48,146,153,186],"periodontitis.":[49],"The":[50,108],"aim":[51],"study":[54,194],"was":[55,79,110,121,144],"investigate":[57],"association":[59,123],"between":[60,124],"+17":[61],"(T/C)":[62,175],"+49":[65,181],"(A/G)":[66,182],"CTLA-4":[67,143,180],"periodontitis":[71,134,155,204],"Brazilians.":[73,206],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"Genomic":[77],"DNA":[78],"obtained":[80],"from":[81],"oral":[82],"swabs":[83],"424":[85],"individuals":[86],"categorized":[87],"into":[88],"three":[89],"groups":[90],"(control":[91],"group,":[92],"aggressive,":[93],"chronic":[95],"periodontitis)":[96],"considering":[97],"clinical":[98,105,148],"parameters":[99],"probing":[102],"depth":[103],"attachment":[106,149],"loss.":[107],"genotyping":[109],"performed":[111],"polymerase":[113],"chain":[114],"reaction-restriction":[115],"fragment":[116],"length":[117],"polymorphism.":[118],"RESULTS:":[119],"There":[120],"an":[122],"T(-)":[126,170],"genotype":[127,141],"polymorphism":[131],"aggressive":[133,154,189],"(P":[135,156],"=":[136,157,160,163],"0.04).":[137],"Moreover,":[138],"A(+)":[140,178],"greater":[147],"loss":[150],"non-smokers":[152],"0.006,":[158],"OR":[159],"16.25,":[161],"CI":[162],"2.25-117.11).":[164],"CONCLUSIONS:":[165],"These":[166],"findings":[167],"show":[168],"+":[173],"17":[174],"genotypes":[183],"susceptibility":[187,201],"disease.":[191],"Thus,":[192],"our":[193],"highlights":[195],"potential":[199],"genetic":[200],"markers":[202]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}