{"id":"https://openalex.org/W2005157049","doi":"https://doi.org/10.1186/1471-2407-10-641","title":"Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis","display_name":"Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W2005157049","doi":"https://doi.org/10.1186/1471-2407-10-641","mag":"2005157049","pmid":"https://pubmed.ncbi.nlm.nih.gov/21092311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001720"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-10-641","doi":"https://doi.org/10.1186/1471-2407-10-641","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-641","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-641","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068733356","display_name":"Dusan Djokovic","orcid":"https://orcid.org/0000-0002-1013-8455","observed_orcids":["https://orcid.org/0000-0002-1013-8455"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Dusan Djokovic","raw_affiliation_strings":["Department of Pathology, University of Southern California, Los Angeles, USA","Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001109188","display_name":"Alexandre Trindade","orcid":"https://orcid.org/0000-0002-3104-9259","observed_orcids":["https://orcid.org/0000-0002-3104-9259"]},"institutions":[{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Alexandre Trindade","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083579938","display_name":"Joana Gigante","orcid":"https://orcid.org/0000-0002-2414-7651","observed_orcids":["https://orcid.org/0000-0002-2414-7651"]},"institutions":[{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Gigante","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071390319","display_name":"Marina Badenes","orcid":"https://orcid.org/0000-0001-6872-891X","observed_orcids":["https://orcid.org/0000-0001-6872-891X"]},"institutions":[{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marina Badenes","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086741028","display_name":"Lilliana Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lilliana Silva","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389644","display_name":"Ren Liu","orcid":"https://orcid.org/0000-0003-1809-1441","observed_orcids":["https://orcid.org/0000-0003-1809-1441"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ren Liu","raw_affiliation_strings":["Department of Pathology, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046796759","display_name":"Xiu\u2010Qing Li","orcid":"https://orcid.org/0000-0002-7308-0596","observed_orcids":["https://orcid.org/0000-0002-7308-0596"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuqing Li","raw_affiliation_strings":["Department of Pathology, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085840076","display_name":"Ming Gong","orcid":"https://orcid.org/0000-0002-2064-3623","observed_orcids":["https://orcid.org/0000-0002-2064-3623"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Gong","raw_affiliation_strings":["Department of Pathology, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017599867","display_name":"Valery G. Krasnoperov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092376","display_name":"VasGene Therapeutics (United States)","ror":"https://ror.org/00jat8r15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210092376"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valery Krasnoperov","raw_affiliation_strings":["Vasgene Therapeutics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vasgene Therapeutics, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210092376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103151393","display_name":"Parkash S. Gill","orcid":"https://orcid.org/0000-0003-4919-7337","observed_orcids":["https://orcid.org/0000-0003-4919-7337"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Parkash S Gill","raw_affiliation_strings":["Department of Medicine, University of Southern California, Los Angeles, USA","Department of Pathology, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061713911","display_name":"Ant\u00f3nio Duarte","orcid":"https://orcid.org/0000-0002-9255-3635","observed_orcids":["https://orcid.org/0000-0002-9255-3635"]},"institutions":[{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Antonio Duarte","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405253863","https://openalex.org/I4405264366"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103151393"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":4.5562,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.95766773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"641","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dll4-notch-signaling","display_name":"Dll4-Notch signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/combination-targeted-therapy","display_name":"combination targeted therapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-microvessel-density","display_name":"tumor microvessel density","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.7604168653488159},{"id":"https://openalex.org/C111758988","wikidata":"https://www.wikidata.org/wiki/Q6937269","display_name":"Mural cell","level":4,"score":0.6214383840560913},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5567871928215027},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5181023478507996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3700219690799713},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35788899660110474},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.29126113653182983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2816610336303711},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2470969557762146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1954023838043213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08117231726646423},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07134956121444702}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D036224","descriptor_name":"Receptor, EphB4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036388","descriptor_name":"Ephrin-B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2407-10-641","doi":"https://doi.org/10.1186/1471-2407-10-641","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-641","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-641","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2026439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3001720","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001720","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:21092311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21092311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4c4534790c85495b930929bc385a5a4b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4c4534790c85495b930929bc385a5a4b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 10, Iss 1, p 641 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-10-641","doi":"https://doi.org/10.1186/1471-2407-10-641","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-641","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-641","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5155874059","display_name":"VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma","funder_award_id":"R01CA079218","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005157049.pdf","grobid_xml":"https://content.openalex.org/works/W2005157049.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1971162717","https://openalex.org/W1973096186","https://openalex.org/W1974195547","https://openalex.org/W1980819464","https://openalex.org/W1987662957","https://openalex.org/W1988615699","https://openalex.org/W1996430165","https://openalex.org/W1999429794","https://openalex.org/W2001879388","https://openalex.org/W2015809080","https://openalex.org/W2017176305","https://openalex.org/W2017322644","https://openalex.org/W2018516857","https://openalex.org/W2019817592","https://openalex.org/W2030370645","https://openalex.org/W2040827891","https://openalex.org/W2043071367","https://openalex.org/W2043508733","https://openalex.org/W2051319925","https://openalex.org/W2056916102","https://openalex.org/W2062240872","https://openalex.org/W2063899343","https://openalex.org/W2070636596","https://openalex.org/W2073465941","https://openalex.org/W2075773133","https://openalex.org/W2076076619","https://openalex.org/W2078554706","https://openalex.org/W2089723533","https://openalex.org/W2100100832","https://openalex.org/W2102056525","https://openalex.org/W2105891671","https://openalex.org/W2108212727","https://openalex.org/W2111517972","https://openalex.org/W2115390024","https://openalex.org/W2123486053","https://openalex.org/W2128295200","https://openalex.org/W2147435977","https://openalex.org/W2153186684","https://openalex.org/W2153726848"],"related_works":["https://openalex.org/W181837403","https://openalex.org/W6889418963","https://openalex.org/W2966960773","https://openalex.org/W2595099647","https://openalex.org/W3021227184","https://openalex.org/W2105891671","https://openalex.org/W2129948672","https://openalex.org/W2019817592","https://openalex.org/W2040827891","https://openalex.org/W2069481318"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dll4/Notch":[1,60,212,227],"and":[2,12,27,39,88,118,141,157,188,213,223],"Ephrin-B2/EphB4":[3,77,214],"pathways":[4,93],"play":[5],"critical":[6],"roles":[7],"in":[8,28,30,132,146,181],"tumor":[9,38,50,134,148,164,184],"vessel":[10,135,142,155,158,186],"development":[11],"maturation.":[13],"This":[14],"study":[15,53],"evaluates":[16],"the":[17,20,32,47,54],"efficacy":[18,167,222],"of":[19,22,34,56,59,68,76,91,163,211],"inhibition":[21,58,75,90,228],"both":[23,92],"signaling":[24,78],"pathways,":[25],"alone":[26],"combination,":[29],"reducing":[31],"growth":[33],"an":[35],"autochthonous":[36],"mouse":[37],"assesses":[40],"potential":[41,216],"adverse":[42,106],"effects.":[43],"METHODS:":[44],"We":[45],"used":[46,109],"transgenic":[48],"RIP1-Tag2":[49],"model":[51],"to":[52,85,161,183],"effects":[55],"1)":[57],"by":[61,79,94,204],"either":[62,98,175],"Dll4":[63,72,99,112,124,129,176,195],"allelic":[64,100],"deletion":[65,101,126,178],"or":[66,102,127,179],"use":[67],"a":[69,80],"soluble":[70,81,128,151],"extracellular":[71,82],"(sDll4),":[73],"2)":[74],"EphB4":[83,152],"fused":[84],"albumin":[86],"(sEphB4-Alb),":[87],"3)":[89],"sEphB4-Alb":[95,171,206],"combined":[96,173],"with":[97,116,174],"sDll4.":[103],"To":[104],"investigate":[105],"effects,":[107],"we":[108],"inducible":[110],"endothelial-specific":[111],"knock-out":[113],"mice,":[114],"treated":[115],"sEphB4-Alb,":[117],"carried":[119],"out":[120],"histopathological":[121],"analysis.":[122],"RESULTS:":[123],"allele":[125,177],"treatment":[130],"resulted":[131,145],"increased":[133,224],"density,":[136],"reduced":[137,147,154],"mural":[138,189],"cell":[139,190],"recruitment":[140],"perfusion":[143,187],"which":[144,201],"size.":[149,165],"The":[150],"instead":[153],"density":[156],"perfusion,":[159],"leading":[160],"reduction":[162],"Greater":[166],"was":[168,172],"observed":[169],"when":[170],"sDll4":[180],"regards":[182],"size,":[185],"recruitment.":[191],"Induced":[192],"endothelial":[193],"specific":[194],"loss-of-function":[196],"caused":[197],"hepatic":[198],"vascular":[199],"alterations,":[200],"were":[202],"prevented":[203],"concomitant":[205],"treatment.":[207],"CONCLUSION:":[208],"Combination":[209],"targeting":[210],"has":[215],"for":[217],"clinical":[218],"investigation,":[219],"providing":[220],"cumulative":[221],"safety":[225],"over":[226],"alone.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}