{"id":"https://openalex.org/W2005145424","doi":"https://doi.org/10.1507/endocrj1954.30.523","title":"Treatment of idiopathic pituitary dwarfism with methionyl human growth hormone.","display_name":"Treatment of idiopathic pituitary dwarfism with methionyl human growth hormone.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2005145424","doi":"https://doi.org/10.1507/endocrj1954.30.523","mag":"2005145424","pmid":"https://pubmed.ncbi.nlm.nih.gov/6671456"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj1954.30.523","doi":"https://doi.org/10.1507/endocrj1954.30.523","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.30.523","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/30/4/30_4_523/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1954/30/4/30_4_523/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021226292","display_name":"Kazue Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUE TAKANO","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033893823","display_name":"KAZUO SHIZUME","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUO SHIZUME","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012129165","display_name":"Naomi Hizuka","orcid":"https://orcid.org/0009-0006-4153-1766","observed_orcids":["https://orcid.org/0009-0006-4153-1766"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOMI HIZUKA","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026474548","display_name":"Itsuro Hibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282054","display_name":"National Children's Hospital","ror":"https://ror.org/058vv9y91","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I1293811555","https://openalex.org/I4210117550","https://openalex.org/I4405282054"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"ITSURO HIBI","raw_affiliation_strings":["Department of Medicine, National Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Children's Hospital","institution_ids":["https://openalex.org/I4405282054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113941488","display_name":"Kiyohiko Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOHIKO KATO","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048027547","display_name":"Hitoshi Kohno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HITOSHI KOHNO","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039396330","display_name":"Takuma Kondo","orcid":"https://orcid.org/0000-0003-1569-0190","observed_orcids":["https://orcid.org/0000-0003-1569-0190"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TAKUMA KONDO","raw_affiliation_strings":["Department of Pediatrics, Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Medical Center","institution_ids":["https://openalex.org/I1297463080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021427","display_name":"Masamichi Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAMICHI OGAWA","raw_affiliation_strings":["Department of Pediatrics, Nagoya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nagoya University","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048208111","display_name":"Yoshiaki Okada","orcid":"https://orcid.org/0000-0002-2962-244X","observed_orcids":["https://orcid.org/0000-0002-2962-244X"]},"institutions":[{"id":"https://openalex.org/I4210109301","display_name":"Yodogawa Christian Hospital","ror":"https://ror.org/01ybxrm80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109301"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIAKI OKADA","raw_affiliation_strings":["Department of Pediatrics, Yodogawa Christian's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yodogawa Christian's Hospital","institution_ids":["https://openalex.org/I4210109301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663851","display_name":"Masakatsu Sudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAKATSU SUDO","raw_affiliation_strings":["Department of Pediatrics, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112642247","display_name":"Seizo Suwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115195","display_name":"Kanagawa Children's Medical Center","ror":"https://ror.org/022h0tq76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEIZO SUWA","raw_affiliation_strings":["Department of Pediatrics, Kanagawa Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kanagawa Children's Medical Center","institution_ids":["https://openalex.org/I4210115195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109500127","display_name":"Jiro Takahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JIRO TAKAHARA","raw_affiliation_strings":["Department of Medicine, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3585,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91495268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"4","first_page":"523","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-growth-hormone-therapy","display_name":"recombinant human growth hormone therapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/height-gain","display_name":"height gain","score":0.593999981880188},{"id":"https://openalex.org/keywords/anti-growth-hormone-antibodies","display_name":"anti-growth hormone antibodies","score":0.9350000023841858},{"id":"https://openalex.org/keywords/growth-rate","display_name":"growth rate","score":0.5680000185966492},{"id":"https://openalex.org/keywords/short-stature","display_name":"short stature","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778111144","wikidata":"https://www.wikidata.org/wiki/Q194101","display_name":"Dwarfism","level":3,"score":0.8311781883239746},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7460231781005859},{"id":"https://openalex.org/C2994100043","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Human growth hormone","level":4,"score":0.7353787422180176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7258539795875549},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6366370916366577},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5822114944458008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5602824687957764},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5332887768745422},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42545604705810547},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.4241650700569153},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3510240316390991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26738351583480835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13585355877876282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.055285125970840454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004393","descriptor_name":"Dwarfism, Pituitary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj1954.30.523","doi":"https://doi.org/10.1507/endocrj1954.30.523","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.30.523","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/30/4/30_4_523/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},{"id":"pmid:6671456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6671456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia japonica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj1954.30.523","doi":"https://doi.org/10.1507/endocrj1954.30.523","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.30.523","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/30/4/30_4_523/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005145424.pdf","grobid_xml":"https://content.openalex.org/works/W2005145424.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1975477736","https://openalex.org/W1980214906","https://openalex.org/W1981503486","https://openalex.org/W1982133966","https://openalex.org/W1985526577","https://openalex.org/W1996538411","https://openalex.org/W2014541959","https://openalex.org/W2019809373","https://openalex.org/W2049537700","https://openalex.org/W2093968318","https://openalex.org/W2099157708"],"related_works":["https://openalex.org/W1995352927","https://openalex.org/W1986135854","https://openalex.org/W6998127923","https://openalex.org/W2075301538","https://openalex.org/W2095165351","https://openalex.org/W1976598143","https://openalex.org/W2105036599","https://openalex.org/W2099157708","https://openalex.org/W1978196119","https://openalex.org/W2409380009"],"abstract_inverted_index":{"Ten":[0],"patients":[1,78],"with":[2,8,65,86],"idiopathic":[3],"pituitary":[4],"dwarfism":[5],"were":[6,20,30],"treated":[7],"methionyl":[9],"human":[10],"growth":[11,101],"hormone":[12],"(met-hGH)":[13],"produced":[14],"by":[15],"recombinant":[16],"DNA":[17],"technology.":[18],"They":[19],"given":[21],"0.5":[22],"IU/kg/week":[23],"of":[24,51,69,84,95,98,108],"met-hGH":[25],"for":[26],"three":[27],"months.":[28],"There":[29],"no":[31],"significant":[32],"changes":[33],"in":[34,76,106],"physical,":[35],"blood,":[36],"urine":[37],"examinations.":[38],"Their":[39],"height":[40],"increased":[41],"between":[42,79,89],"1.5":[43],"and":[44,60,81,91],"2.7":[45],"cm":[46,62],"during":[47],"the":[48,96,100,109],"3":[49],"months":[50,83],"treatment,":[52],"which":[53],"was":[54,74],"calculated":[55],"to":[56],"be":[57],"equivalent":[58],"6.0":[59],"10.8":[61],"per":[63],"year":[64],"a":[66,87],"mean":[67],"increase":[68],"8.7":[70],"cm.":[71],"Anti-hGH":[72],"antibody":[73],"observed":[75],"all":[77],"one":[80],"two":[82],"treatment":[85],"titer":[88],"10(1)X":[90],"10(4)X.":[92],"In":[93],"spite":[94],"formation":[97],"antibodies,":[99],"rate":[102],"did":[103],"not":[104],"decrease":[105],"7":[107],"10":[110],"cases.":[111]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
