{"id":"https://openalex.org/W2005142726","doi":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","title":"DEVELOPMENT OF A RADIOIMMUNOASSAY FOR AN AMINO\u2010TERMINAL PEPTIDE OF PRO\u2010OPIOCORTIN CONTAINING THE \u03b3\u2010MSH REGION: MEASUREMENT AND CHARACTERIZATION IN HUMAN PLASMA","display_name":"DEVELOPMENT OF A RADIOIMMUNOASSAY FOR AN AMINO\u2010TERMINAL PEPTIDE OF PRO\u2010OPIOCORTIN CONTAINING THE \u03b3\u2010MSH REGION: MEASUREMENT AND CHARACTERIZATION IN HUMAN PLASMA","publication_year":1981,"publication_date":"1981-09-01","ids":{"openalex":"https://openalex.org/W2005142726","doi":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","mag":"2005142726","pmid":"https://pubmed.ncbi.nlm.nih.gov/6273026"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.1981.tb00658.x","doi":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101644021","display_name":"Jessica Elizabeth Hope","orcid":"https://orcid.org/0000-0003-4389-1037","observed_orcids":["https://orcid.org/0000-0003-4389-1037"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. HOPE","raw_affiliation_strings":["Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111794219","display_name":"Sally J. Ratter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SALLY J. RATTER","raw_affiliation_strings":["Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043012794","display_name":"Fernando E. Estivariz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. E. ESTIVARIZ","raw_affiliation_strings":["Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110144954","display_name":"Lorraine McLoughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LORRAINE McLOUGHLIN","raw_affiliation_strings":["Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111826454","display_name":"Philip J. Lowry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. J. LOWRY","raw_affiliation_strings":["Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Pathology and Chemical Endocrinology, St Bartholomew's Hospital, London","institution_ids":["https://openalex.org/I1307195382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101644021"],"corresponding_institution_ids":["https://openalex.org/I1307195382"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":8.9828,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.98550268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"3","first_page":"221","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-melanocyte-stimulating-hormone","display_name":"gamma-MSH","score":0.8289999961853027},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8740000128746033},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.7260000109672546},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.847000002861023},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.9488508701324463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7246646285057068},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.7174317836761475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7025095224380493},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.6960368156433105},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.670159637928009},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5842111706733704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5390986204147339},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.5378730297088623},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.5336872339248657},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5230282545089722},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5007367134094238},{"id":"https://openalex.org/C3018824666","wikidata":"https://www.wikidata.org/wiki/Q284398","display_name":"Amino terminal","level":4,"score":0.48362886905670166},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.4401082694530487},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.42606693506240845},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3385927081108093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2794308662414551},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.27180707454681396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26296454668045044},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.23084506392478943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15227976441383362},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08219492435455322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07928448915481567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000182","descriptor_name":"ACTH Syndrome, Ectopic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000224","descriptor_name":"Addison Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009074","descriptor_name":"Melanocyte-Stimulating Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009347","descriptor_name":"Nelson Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010908","descriptor_name":"Pituitary Hormones, Anterior","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.1981.tb00658.x","doi":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1981.tb00658.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:6273026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6273026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W13155899","https://openalex.org/W151261625","https://openalex.org/W561171043","https://openalex.org/W1984585262","https://openalex.org/W2002664886","https://openalex.org/W2009805403","https://openalex.org/W2017402132","https://openalex.org/W2034377496","https://openalex.org/W2036638320","https://openalex.org/W2051033294","https://openalex.org/W2058793979","https://openalex.org/W2071488442","https://openalex.org/W2089018293","https://openalex.org/W2107886281"],"related_works":["https://openalex.org/W2033275712","https://openalex.org/W2048218984","https://openalex.org/W2082602612","https://openalex.org/W2028119873","https://openalex.org/W1975651762","https://openalex.org/W2114420323","https://openalex.org/W2015433191","https://openalex.org/W2418860566","https://openalex.org/W1981281318","https://openalex.org/W2080542461"],"abstract_inverted_index":{"A":[0],"radioimmunoassay":[1],"has":[2],"been":[3],"developed":[4],"for":[5],"the":[6,14,29,48,53,84],"N-terminal":[7],"region":[8],"of":[9,18,34,39,52,65,73,83],"human":[10,46],"pituitary":[11],"pro-opiocortin":[12],"(N-POC),":[13],"common":[15],"precursor":[16],"protein":[17],"ACTH":[19,74],"and":[20],"beta-LPH,":[21],"using":[22],"an":[23],"antiserum":[24],"which":[25],"recognizes":[26],"residues":[27],"near":[28],"gamma-MSH":[30],"region.":[31],"The":[32,63],"concentrations":[33,64],"greater":[35],"than":[36],"300":[37],"ng/l":[38],"immunoreactive":[40,66],"peptide":[41],"were":[42,69],"determined":[43],"in":[44,75],"unextracted":[45],"plasma,":[47],"relative":[49],"molecular":[50],"mass":[51],"reacting":[54],"fragments":[55],"corresponding":[56],"to":[57],"a":[58],"seventy-seven":[59],"amino":[60],"acid":[61],"glycoprotein.":[62],"N-POC":[67],"peptides":[68],"correlated":[70],"with":[71,80],"those":[72],"plasma":[76],"obtained":[77],"from":[78],"patients":[79],"various":[81],"disorders":[82],"hypothalamic-pituitary-adrenal":[85],"axis.":[86]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}