{"id":"https://openalex.org/W2005134483","doi":"https://doi.org/10.1039/c2ob25647a","title":"7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove","display_name":"7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2005134483","doi":"https://doi.org/10.1039/c2ob25647a","mag":"2005134483","pmid":"https://pubmed.ncbi.nlm.nih.gov/22766576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3417767"},"language":"en","primary_location":{"id":"doi:10.1039/c2ob25647a","doi":"https://doi.org/10.1039/c2ob25647a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2ob25647a","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic &amp; Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3417767","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022649156","display_name":"Jos\u00e9 M. Ibarra\u2010Soza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Ibarra-Soza","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009184617","display_name":"Alexi A. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexi A. Morris","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091564168","display_name":"Prasanna Jayalath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasanna Jayalath","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036824067","display_name":"Hayden Peacock","orcid":"https://orcid.org/0000-0002-6875-9019","observed_orcids":["https://orcid.org/0000-0002-6875-9019"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayden Peacock","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044235397","display_name":"Wayne E. Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne E. Conrad","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038862674","display_name":"Michael B. Donald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Donald","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002153833","display_name":"Mark J. Kurth","orcid":"https://orcid.org/0000-0001-8496-6125","observed_orcids":["https://orcid.org/0000-0001-8496-6125"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Kurth","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064820122","display_name":"Peter A. Beal","orcid":"https://orcid.org/0000-0003-4855-7185","observed_orcids":["https://orcid.org/0000-0003-4855-7185"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A. Beal","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California-Davis, One Shields Avenue, Davis,,USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064820122"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.5249,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.58467221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"32","first_page":"6491","last_page":"6491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azide-alkyne-cycloaddition","display_name":"azide-alkyne cycloaddition","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rna-duplex-stability","display_name":"RNA duplex stability","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8363735675811768},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.7442352175712585},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6321204900741577},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.607353925704956},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5324082970619202},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5012047290802002},{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.48385441303253174},{"id":"https://openalex.org/C2776844798","wikidata":"https://www.wikidata.org/wiki/Q34402","display_name":"Ribonucleoside","level":4,"score":0.46296051144599915},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45929497480392456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27915576100349426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10680866241455078},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/c2ob25647a","doi":"https://doi.org/10.1039/c2ob25647a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2ob25647a","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic &amp; Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:22766576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22766576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2742998","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3417767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3417767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3417767","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Org Biomol Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2742998","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3417767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7013296652","display_name":"Nucleobase analog for the next generation siRNa","funder_award_id":"R01GM080784","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1535643053","https://openalex.org/W1964401257","https://openalex.org/W1972637758","https://openalex.org/W1977619408","https://openalex.org/W1980060890","https://openalex.org/W1987515818","https://openalex.org/W1993708532","https://openalex.org/W2000062507","https://openalex.org/W2007266405","https://openalex.org/W2007466324","https://openalex.org/W2008570158","https://openalex.org/W2023557482","https://openalex.org/W2024536147","https://openalex.org/W2027954222","https://openalex.org/W2030828211","https://openalex.org/W2034394760","https://openalex.org/W2039078523","https://openalex.org/W2043828851","https://openalex.org/W2045554371","https://openalex.org/W2054166086","https://openalex.org/W2059073003","https://openalex.org/W2063335334","https://openalex.org/W2066004189","https://openalex.org/W2073741546","https://openalex.org/W2075402066","https://openalex.org/W2076939529","https://openalex.org/W2078942441","https://openalex.org/W2079806558","https://openalex.org/W2080581230","https://openalex.org/W2089962897","https://openalex.org/W2107762071","https://openalex.org/W2111066814","https://openalex.org/W2111831519","https://openalex.org/W2132691262","https://openalex.org/W2145982655","https://openalex.org/W2159068871","https://openalex.org/W2161836629","https://openalex.org/W2163987996","https://openalex.org/W2165286214","https://openalex.org/W2165372505","https://openalex.org/W2165586566","https://openalex.org/W2312877065","https://openalex.org/W2331666973","https://openalex.org/W3145257564","https://openalex.org/W4256503849"],"related_works":["https://openalex.org/W2079806558","https://openalex.org/W1966625970","https://openalex.org/W2153594569","https://openalex.org/W2273244442","https://openalex.org/W2060256979","https://openalex.org/W2040884830","https://openalex.org/W2000958467","https://openalex.org/W2015484568","https://openalex.org/W2137520154","https://openalex.org/W4416824629"],"abstract_inverted_index":{"Here":[0],"we":[1,40],"describe":[2],"the":[3,29,45,61],"synthesis":[4,34],"of":[5,28,47,66,69],"new":[6],"7-substituted":[7],"8-aza-7-deazaadenosine":[8],"ribonucleoside":[9],"phosphoramidites":[10],"and":[11,57,95],"their":[12],"use":[13],"in":[14,75,101],"generating":[15],"major":[16],"groove-modified":[17],"duplex":[18,55],"RNAs.":[19],"A":[20],"7-ethynyl":[21],"analog":[22],"leads":[23],"to":[24],"further":[25],"structural":[26],"diversification":[27],"RNA":[30,33,54],"via":[31],"post-automated":[32],"azide-alkyne":[35],"cycloaddition":[36],"reactions.":[37],"In":[38],"addition,":[39],"report":[41],"preliminary":[42],"studies":[43],"on":[44,53,63],"effects":[46],"eight":[48,72],"different":[49,73],"purine":[50],"7-position":[51,88],"modifications":[52],"stability":[56],"pairing":[58,93],"specificity.":[59],"Finally,":[60],"effect":[62],"RNAi":[64],"activity":[65],"this":[67],"type":[68],"modification":[70],"at":[71,98],"positions":[74,100],"an":[76,102],"siRNA":[77,103],"guide":[78,104],"strand":[79],"has":[80],"been":[81],"explored.":[82],"Analogs":[83],"were":[84],"identified":[85],"with":[86],"large":[87],"substituents":[89],"that":[90],"maintain":[91],"adenosine":[92],"specificity":[94],"are":[96],"well-tolerated":[97],"specific":[99],"strand.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
