{"id":"https://openalex.org/W2005134040","doi":"https://doi.org/10.1523/jneurosci.1623-07.2007","title":"Mice Lacking Central Serotonergic Neurons Show Enhanced Inflammatory Pain and an Impaired Analgesic Response to Antidepressant Drugs","display_name":"Mice Lacking Central Serotonergic Neurons Show Enhanced Inflammatory Pain and an Impaired Analgesic Response to Antidepressant Drugs","publication_year":2007,"publication_date":"2007-05-30","ids":{"openalex":"https://openalex.org/W2005134040","doi":"https://doi.org/10.1523/jneurosci.1623-07.2007","mag":"2005134040","pmid":"https://pubmed.ncbi.nlm.nih.gov/17537976"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1623-07.2007","doi":"https://doi.org/10.1523/jneurosci.1623-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1623-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/22/6045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/27/22/6045.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111542570","display_name":"Zhong-Qiu Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong-Qiu Zhao","raw_affiliation_strings":["Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026954701","display_name":"Santina Chiechio","orcid":"https://orcid.org/0000-0003-4648-391X","observed_orcids":["https://orcid.org/0000-0003-4648-391X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Santina Chiechio","raw_affiliation_strings":["Washington University Pain Center and Departments of 2 Anesthesiology ,","University of Catania","Washington University St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University Pain Center and Departments of 2 Anesthesiology ,","institution_ids":[]},{"raw_affiliation_string":"University of Catania","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Washington University St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111880247","display_name":"Yan-Gang Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan-Gang Sun","raw_affiliation_strings":["Washington University Pain Center and Departments of 2 Anesthesiology ,","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University Pain Center and Departments of 2 Anesthesiology ,","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840783","display_name":"Kai\u2010Hua Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai-Hua Zhang","raw_affiliation_strings":["Washington University Pain Center and Departments of 2 Anesthesiology ,","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University Pain Center and Departments of 2 Anesthesiology ,","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102110246","display_name":"Chengshui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng-Shui Zhao","raw_affiliation_strings":["Washington University Pain Center and Departments of 2 Anesthesiology ,","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University Pain Center and Departments of 2 Anesthesiology ,","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030904270","display_name":"Michael M. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Scott","raw_affiliation_strings":["Department of Neuroscience , School of Medicine , Case Western Reserve University , Cleveland , Ohio 44106 ,","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience , School of Medicine , Case Western Reserve University , Cleveland , Ohio 44106 ,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069957994","display_name":"Randy L. Johnson","orcid":"https://orcid.org/0000-0003-4549-3593","observed_orcids":["https://orcid.org/0000-0003-4549-3593"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy L. Johnson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology , M. D. Anderson Cancer Center , University of Texas Health Science Center at Houston , Texas 77030 , and","Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology , M. D. Anderson Cancer Center , University of Texas Health Science Center at Houston , Texas 77030 , and","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023395524","display_name":"Evan S. Deneris","orcid":"https://orcid.org/0000-0003-4211-9934","observed_orcids":["https://orcid.org/0000-0003-4211-9934"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan S. Deneris","raw_affiliation_strings":["Department of Neuroscience , School of Medicine , Case Western Reserve University , Cleveland , Ohio 44106 ,","Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience , School of Medicine , Case Western Reserve University , Cleveland , Ohio 44106 ,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103562470","display_name":"Kenneth J. Renner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Kenneth J. Renner","raw_affiliation_strings":["Department of Biology , The University of South Dakota , Vermillion , South Dakota 57069","Department of Pharmaceutical Sciences , University of Catania , 95125 Catania , Italy","#N#        University of South Dakota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology , The University of South Dakota , Vermillion , South Dakota 57069","institution_ids":["https://openalex.org/I189957204"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences , University of Catania , 95125 Catania , Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"#N#        University of South Dakota","institution_ids":["https://openalex.org/I189957204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006363718","display_name":"Robert W. Gereau","orcid":"https://orcid.org/0000-0002-5428-4251","observed_orcids":["https://orcid.org/0000-0002-5428-4251"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Gereau","raw_affiliation_strings":["Anatomy and Neurobiology , Washington University School of Medicine , St. Louis , Missouri 63110 ,","Washington University Pain Center and Departments of 2 Anesthesiology ,","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy and Neurobiology , Washington University School of Medicine , St. Louis , Missouri 63110 ,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University Pain Center and Departments of 2 Anesthesiology ,","institution_ids":[]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025792713","display_name":"Zhou\u2010Feng Chen","orcid":"https://orcid.org/0000-0002-6859-7910","observed_orcids":["https://orcid.org/0000-0002-6859-7910"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhou-Feng Chen","raw_affiliation_strings":["Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.303,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98055318,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"22","first_page":"6045","last_page":"6053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.734000027179718},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mechanical-pain","display_name":"mechanical pain","score":0.6679999828338623},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":1.0},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9200000166893005},{"id":"https://openalex.org/keywords/descending-pain-modulation","display_name":"descending pain modulation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.7440000176429749},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8433408737182617},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7984870672225952},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7967342138290405},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.6618759036064148},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.6554790139198303},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6296547651290894},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6178763508796692},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.5579283237457275},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5204463601112366},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.5074707865715027},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.4991645812988281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4830251634120941},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.4328760802745819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24735909700393677},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.12179559469223022},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06581985950469971},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1623-07.2007","doi":"https://doi.org/10.1523/jneurosci.1623-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1623-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/22/6045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:17537976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17537976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6672267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6672267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1623-07.2007","doi":"https://doi.org/10.1523/jneurosci.1623-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1623-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/22/6045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G758343326","display_name":null,"funder_award_id":"P30 NS057105","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005134040.pdf","grobid_xml":"https://content.openalex.org/works/W2005134040.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W33374171","https://openalex.org/W1511198581","https://openalex.org/W1531562561","https://openalex.org/W1635709196","https://openalex.org/W1831769215","https://openalex.org/W1848358048","https://openalex.org/W1969040411","https://openalex.org/W1984259090","https://openalex.org/W1988677318","https://openalex.org/W1999194329","https://openalex.org/W2000776930","https://openalex.org/W2004522624","https://openalex.org/W2012538927","https://openalex.org/W2013670271","https://openalex.org/W2014007136","https://openalex.org/W2014186540","https://openalex.org/W2019674556","https://openalex.org/W2019886663","https://openalex.org/W2032627096","https://openalex.org/W2035221267","https://openalex.org/W2035265385","https://openalex.org/W2036062643","https://openalex.org/W2040167442","https://openalex.org/W2040540166","https://openalex.org/W2041772398","https://openalex.org/W2042430137","https://openalex.org/W2044648344","https://openalex.org/W2045898875","https://openalex.org/W2050707182","https://openalex.org/W2052250643","https://openalex.org/W2057494048","https://openalex.org/W2062700118","https://openalex.org/W2068512721","https://openalex.org/W2073541816","https://openalex.org/W2083666090","https://openalex.org/W2084190290","https://openalex.org/W2091061257","https://openalex.org/W2102023851","https://openalex.org/W2102197505","https://openalex.org/W2106522962","https://openalex.org/W2106807118","https://openalex.org/W2136699526","https://openalex.org/W2138512124","https://openalex.org/W2147111949","https://openalex.org/W2153292899","https://openalex.org/W2167244529","https://openalex.org/W2328445755","https://openalex.org/W2467447449"],"related_works":["https://openalex.org/W2008136659","https://openalex.org/W1994256806","https://openalex.org/W2806801135","https://openalex.org/W2141371342","https://openalex.org/W2046485125","https://openalex.org/W2179806938","https://openalex.org/W1509203345","https://openalex.org/W2021185951","https://openalex.org/W1985823019","https://openalex.org/W4283362117"],"abstract_inverted_index":{"A":[0],"large":[1],"body":[2],"of":[3,13,23,68,105,130,154,173,177,180,185],"literature":[4],"has":[5],"implicated":[6],"serotonin":[7,74],"[5-hydroxytryptamine":[8],"(5-HT)]":[9],"in":[10,33,91,95,120,135,142,182],"descending":[11],"modulation":[12],"nociceptive":[14],"transmission.":[15],"Here,":[16],"we":[17],"have":[18],"studied":[19],"the":[20,34,65,96,102,106,110,127,131,151,162,171,174,183],"pain":[21,44,57,100,137,145],"behavior":[22],"Lmx1b":[24],"conditional":[25],"knock-out":[26],"mice":[27,38],"(Lmx1b(f/f/p)),":[28],"which":[29],"lack":[30],"5-HT":[31,133,164],"neurons":[32],"CNS.":[35],"Lmx1b(f/f/p)":[36,92],"mutant":[37],"showed":[39],"normal":[40],"thermal":[41],"and":[42,53,82,109],"visceral":[43],"responses":[45],"but":[46],"were":[47,113],"less":[48],"sensitive":[49],"to":[50,169],"mechanical":[51,144],"stimuli":[52],"exhibited":[54],"enhanced":[55],"inflammatory":[56,136],"compared":[58],"with":[59],"their":[60],"littermate":[61],"control":[62],"mice.":[63,93],"Importantly,":[64],"analgesic":[66,103,152,175],"effect":[67],"several":[69],"antidepressant":[70,156],"drugs,":[71],"including":[72],"selective":[73],"reuptake":[75,79],"inhibitors":[76,80],"(SSRIs),":[77],"serotonin-norepinephrine":[78],"(SNRIs),":[81],"tricyclic":[83],"antidepressants,":[84],"was":[85],"either":[86],"abolished":[87],"or":[88],"greatly":[89],"attenuated":[90],"Moreover,":[94],"acute":[97,143],"versus":[98],"persistent":[99,186],"settings,":[101],"actions":[104],"SNRI":[107],"duloxetine":[108],"SSRI":[111],"fluoxetine":[112],"differentially":[114,159],"affected.":[115],"Together,":[116],"our":[117],"results":[118],"provide":[119],"vivo":[121],"genetic":[122],"evidence":[123],"demonstrating":[124],"that":[125,150],"although":[126],"predominant":[128],"role":[129,141],"central":[132,163],"system":[134,165],"is":[138,146],"inhibitory,":[139],"its":[140],"facilitatory.":[147],"The":[148],"findings":[149],"effects":[153],"various":[155],"drugs":[157],"are":[158],"dependent":[160],"on":[161],"should":[166],"help":[167],"us":[168],"understand":[170],"mechanism":[172],"action":[176],"different":[178],"classes":[179],"antidepressants":[181],"management":[184],"pain.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}