{"id":"https://openalex.org/W2005133052","doi":"https://doi.org/10.1002/dvdy.21469","title":"PDGF\u2010A as an epicardial mitogen during heart development","display_name":"PDGF\u2010A as an epicardial mitogen during heart development","publication_year":2008,"publication_date":"2008-02-24","ids":{"openalex":"https://openalex.org/W2005133052","doi":"https://doi.org/10.1002/dvdy.21469","mag":"2005133052","pmid":"https://pubmed.ncbi.nlm.nih.gov/18297729"},"language":"en","primary_location":{"id":"doi:10.1002/dvdy.21469","doi":"https://doi.org/10.1002/dvdy.21469","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvdy.21469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21469","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21469","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053377174","display_name":"Ji\u2010One Kang","orcid":"https://orcid.org/0000-0001-9481-6657","observed_orcids":["https://orcid.org/0000-0001-9481-6657"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jione Kang","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA","Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067874194","display_name":"Ying Gu","orcid":"https://orcid.org/0000-0001-7822-0570","observed_orcids":["https://orcid.org/0000-0001-7822-0570"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Gu","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432738","display_name":"Peng Li","orcid":"https://orcid.org/0000-0002-8332-7142","observed_orcids":["https://orcid.org/0000-0002-8332-7142","https://orcid.org/0000-0002-5235-6311"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081916466","display_name":"Betsy L. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betsy L. Johnson","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051995125","display_name":"Henry M. Sucov","orcid":"https://orcid.org/0000-0002-3792-3795","observed_orcids":["https://orcid.org/0000-0002-3792-3795"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry M. Sucov","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113547990","display_name":"Penny S. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penny S. Thomas","raw_affiliation_strings":["Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051995125"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":2.3291,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87924996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"237","issue":"3","first_page":"692","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdgf-a","display_name":"PDGF-A","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epicardium","display_name":"epicardium","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pdgf-signaling","display_name":"PDGF signaling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8654471635818481},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.7673102617263794},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7538262605667114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6171332597732544},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5545102953910828},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.49947309494018555},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4690110385417938},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.46248894929885864},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.45275402069091797},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.44322502613067627},{"id":"https://openalex.org/C85378888","wikidata":"https://www.wikidata.org/wiki/Q721856","display_name":"Endocardium","level":2,"score":0.4264214336872101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4055388569831848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38648277521133423},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3675309419631958},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3341929614543915},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30075162649154663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23200467228889465},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22573614120483398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07628801465034485},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.0678110122680664},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/dvdy.21469","doi":"https://doi.org/10.1002/dvdy.21469","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvdy.21469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21469","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:18297729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18297729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/dvdy.21469","doi":"https://doi.org/10.1002/dvdy.21469","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvdy.21469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21469","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1574475437","display_name":null,"funder_award_id":"CA-62528-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1866755553","display_name":"Cardiomyocyte Proliferation and Ventricular Morphogenesis","funder_award_id":"R01HL070123","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2418453640","display_name":null,"funder_award_id":"HL070123","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2665690755","display_name":null,"funder_award_id":"RR 14514-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3753051074","display_name":"RESEARCH FACILITIES IMPROVEMENT PROGRAM AND REMODELING","funder_award_id":"C06RR014514","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4908468896","display_name":null,"funder_award_id":"RR10600-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8939494464","display_name":"EXTRAMURAL RESEARCH FACILITIES CONTRUCTION PROJECT","funder_award_id":"C06CA062528","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8957204453","display_name":"EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION","funder_award_id":"1c06rr010600-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005133052.pdf","grobid_xml":"https://content.openalex.org/works/W2005133052.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1681560813","https://openalex.org/W1932371007","https://openalex.org/W1939326986","https://openalex.org/W1942976947","https://openalex.org/W1944940278","https://openalex.org/W1948282121","https://openalex.org/W1965128951","https://openalex.org/W1973358829","https://openalex.org/W1982711630","https://openalex.org/W1983228128","https://openalex.org/W1990821669","https://openalex.org/W1994778563","https://openalex.org/W2001260034","https://openalex.org/W2011624509","https://openalex.org/W2013192609","https://openalex.org/W2029707326","https://openalex.org/W2030697707","https://openalex.org/W2033201483","https://openalex.org/W2033261479","https://openalex.org/W2048453807","https://openalex.org/W2054279355","https://openalex.org/W2055752082","https://openalex.org/W2062209057","https://openalex.org/W2063416138","https://openalex.org/W2083398588","https://openalex.org/W2088320964","https://openalex.org/W2096492016","https://openalex.org/W2100164332","https://openalex.org/W2100894820","https://openalex.org/W2102258222","https://openalex.org/W2104248521","https://openalex.org/W2110153861","https://openalex.org/W2111336754","https://openalex.org/W2113596632","https://openalex.org/W2116432506","https://openalex.org/W2122972967","https://openalex.org/W2123808459","https://openalex.org/W2129192872","https://openalex.org/W2143599741","https://openalex.org/W2148037744","https://openalex.org/W2149748854","https://openalex.org/W2155412985","https://openalex.org/W2157592788","https://openalex.org/W2158304082","https://openalex.org/W2163226372","https://openalex.org/W2164468233","https://openalex.org/W2167116126","https://openalex.org/W2186753081","https://openalex.org/W2316594132","https://openalex.org/W4327766722"],"related_works":["https://openalex.org/W7097787444","https://openalex.org/W2153560114","https://openalex.org/W2113775806","https://openalex.org/W2088320964","https://openalex.org/W2000168964","https://openalex.org/W2255260534","https://openalex.org/W2029707326","https://openalex.org/W2055752082","https://openalex.org/W2110458816","https://openalex.org/W1995819796"],"abstract_inverted_index":{"In":[0],"the":[1,7,23,45,68,92,100,117,133,139,178],"developing":[2],"heart,":[3],"reciprocal":[4],"interactions":[5],"between":[6],"epicardium":[8,24,79],"and":[9,15,35,80,86,135],"myocardium":[10,81,109],"drive":[11],"further":[12],"sublineage":[13],"specification":[14],"ventricular":[16],"chamber":[17],"morphogenesis.":[18],"Several":[19],"observations":[20],"suggest":[21],"that":[22,31,154,183],"is":[25,158],"a":[26,103],"source":[27],"of":[28,47,63,91,106,120,138,180],"secreted":[29],"factors":[30,37,50],"influence":[32],"cardiomyocyte":[33],"proliferation,":[34],"these":[36,48],"may":[38,167,184],"have":[39,55,185],"other":[40,171],"roles":[41],"as":[42,61],"well.":[43],"However,":[44],"identity":[46],"epicardial":[49,71],"remains":[51],"mostly":[52],"unknown.":[53],"We":[54],"identified":[56],"platelet-derived":[57],"growth":[58],"factor-A":[59],"(PDGF-A)":[60],"one":[62],"several":[64],"mitogens":[65,182],"expressed":[66],"by":[67,77,87],"rat":[69],"EMC":[70],"cell":[72],"line":[73],"(epicardial":[74],"mesothelial":[75],"cells),":[76],"embryonic":[78],"during":[82],"mouse":[83],"heart":[84,124,162],"development,":[85,125,163],"adult":[88],"epicardium.":[89],"Expression":[90],"cognate":[93],"receptor":[94,130],"gene":[95],"Pdgfra":[96],"was":[97],"detected":[98],"in":[99,108,123,132,146,161],"epicardium,":[101],"although":[102,164],"low":[104],"level":[105],"expression":[107],"could":[110],"not":[111,144,159],"be":[112,168],"ruled":[113],"out.":[114],"To":[115],"address":[116],"potential":[118],"role":[119,166],"PDGF":[121,129,156],"signaling":[122,157,172],"we":[126],"mutated":[127],"both":[128],"genes":[131],"myocardial":[134],"mesodermal":[136,155],"compartments":[137],"heart;":[140],"however,":[141],"this":[142],"did":[143],"result":[145],"an":[147,187],"observable":[148],"cardiac":[149],"phenotype.":[150],"This":[151],"finding":[152],"suggests":[153],"essential":[160],"its":[165],"redundant":[169],"with":[170],"pathways.":[173],"Indeed,":[174],"our":[175],"results":[176],"demonstrate":[177],"presence":[179],"additional":[181],"such":[186],"overlapping":[188],"role.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
