{"id":"https://openalex.org/W2005131604","doi":"https://doi.org/10.1126/science.96524","title":"Excitation-Contraction Coupling in Skeletal Muscle: Blockade by High Extracellular Concentrations of Calcium Buffers","display_name":"Excitation-Contraction Coupling in Skeletal Muscle: Blockade by High Extracellular Concentrations of Calcium Buffers","publication_year":1978,"publication_date":"1978-06-16","ids":{"openalex":"https://openalex.org/W2005131604","doi":"https://doi.org/10.1126/science.96524","mag":"2005131604","pmid":"https://pubmed.ncbi.nlm.nih.gov/96524"},"language":"en","primary_location":{"id":"doi:10.1126/science.96524","doi":"https://doi.org/10.1126/science.96524","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.96524","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022190236","display_name":"John N. Barrett","orcid":"https://orcid.org/0000-0003-3467-9413","observed_orcids":["https://orcid.org/0000-0003-3467-9413"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. N. Barrett","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami Medical School, Miami, Florida 33152"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami Medical School, Miami, Florida 33152","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026493798","display_name":"Ellen F. Barrett","orcid":"https://orcid.org/0000-0001-8483-5993","observed_orcids":["https://orcid.org/0000-0001-8483-5993"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. F. Barrett","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami Medical School, Miami, Florida 33152"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami Medical School, Miami, Florida 33152","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":3.193,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.92487731,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"4347","first_page":"1270","last_page":"1272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9610000252723694},{"id":"https://openalex.org/keywords/calcium-buffers","display_name":"calcium buffers","score":0.9350000023841858},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.75},{"id":"https://openalex.org/keywords/calcium-transport","display_name":"calcium transport","score":0.7459999918937683},{"id":"https://openalex.org/keywords/caffeine-induced-contracture","display_name":"caffeine-induced contracture","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.8044105768203735},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.689497172832489},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6862201690673828},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6468180418014526},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.590888500213623},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5584614872932434},{"id":"https://openalex.org/C114908165","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Excitation\u2013contraction coupling","level":3,"score":0.5330646634101868},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.47143641114234924},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4283583462238312},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4139208197593689},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2671239376068115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2116829752922058},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16432175040245056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10420483350753784},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011894","descriptor_name":"Rana pipiens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.96524","doi":"https://doi.org/10.1126/science.96524","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.96524","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:96524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/96524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1511548987","https://openalex.org/W1956859188","https://openalex.org/W1987726891","https://openalex.org/W2000511037","https://openalex.org/W2010873798","https://openalex.org/W2013548576","https://openalex.org/W2022690878","https://openalex.org/W2034046763","https://openalex.org/W2060502539","https://openalex.org/W2065054453","https://openalex.org/W2070428531","https://openalex.org/W2081311711","https://openalex.org/W2082443566","https://openalex.org/W2086792851","https://openalex.org/W2095152173","https://openalex.org/W2102831779","https://openalex.org/W2105016566","https://openalex.org/W2117036053","https://openalex.org/W2131186219","https://openalex.org/W2154875837"],"related_works":["https://openalex.org/W2031776148","https://openalex.org/W2427212431","https://openalex.org/W2052921249","https://openalex.org/W2404315389","https://openalex.org/W1978167998","https://openalex.org/W2467411665","https://openalex.org/W2145287037","https://openalex.org/W2028586562","https://openalex.org/W2153058077","https://openalex.org/W2418231925"],"abstract_inverted_index":{"High":[0],"concentrations":[1,44],"(80":[2],"to":[3],"90":[4],"millimolar)":[5,49],"of":[6,45,64],"the":[7,37,62,72,86],"calcium":[8,18,40,46,65,78],"buffers":[9],"EGTA":[10],"and":[11,76],"citrate":[12],"(less":[13],"than":[14],"10(-7)":[15],"molar":[16],"free":[17,39],"ion)":[19],"reversibly":[20],"block":[21,32,52],"excitation-contraction":[22,53,59],"coupling":[23,60],"in":[24,66],"intact":[25],"frog":[26],"skeletal":[27],"fibers,":[28],"but":[29,42],"do":[30,50],"not":[31,51],"caffeine-induced":[33],"contractures.":[34],"Solutions":[35],"containing":[36],"same":[38],"concentration":[41],"lower":[43],"buffer":[47],"(1":[48],"coupling.":[54],"These":[55],"results":[56],"suggest":[57],"that":[58,77],"requires":[61],"presence":[63],"a":[67],"\"protected\"":[68],"extracellular":[69],"compartment,":[70],"probably":[71],"transverse":[73],"tubular":[74],"network,":[75],"is":[79],"actively":[80],"transported":[81],"into":[82],"this":[83],"compartment":[84],"from":[85],"muscle":[87],"cell":[88],"cytoplasm.":[89]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
