{"id":"https://openalex.org/W2005126769","doi":"https://doi.org/10.1073/pnas.0600895103","title":"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: Regulation of aquaporin-2 phosphorylation at two sites","display_name":"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: Regulation of aquaporin-2 phosphorylation at two sites","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W2005126769","doi":"https://doi.org/10.1073/pnas.0600895103","mag":"2005126769","pmid":"https://pubmed.ncbi.nlm.nih.gov/16641100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1459033"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0600895103","doi":"https://doi.org/10.1073/pnas.0600895103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0600895103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005126769"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1459033/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006125328","display_name":"Jason D. Hoffert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Hoffert","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, Bethesda, MD 20892","National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026991644","display_name":"Trairak Pisitkun","orcid":"https://orcid.org/0000-0001-6677-2271","observed_orcids":["https://orcid.org/0000-0001-6677-2271","https://orcid.org/0000-0002-2451-0318"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trairak Pisitkun","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, Bethesda, MD 20892","Duke University, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Duke University, Durham, NC,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399474","display_name":"Guanghui Wang","orcid":"https://orcid.org/0000-0001-8551-6468","observed_orcids":["https://orcid.org/0000-0001-8551-6468","https://orcid.org/0009-0005-5601-8220"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanghui Wang","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, Bethesda, MD 20892","Duke University, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Duke University, Durham, NC,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089750450","display_name":"Rong\u2010Fong Shen","orcid":"https://orcid.org/0000-0002-1963-4033","observed_orcids":["https://orcid.org/0000-0002-1963-4033"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong-Fong Shen","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, Bethesda, MD 20892","Duke University, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Duke University, Durham, NC,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029048638","display_name":"Mark A. Knepper","orcid":"https://orcid.org/0000-0002-2276-8091","observed_orcids":["https://orcid.org/0000-0002-2276-8091"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Knepper","raw_affiliation_strings":["National Heart, Lung, and Blood Institute, Bethesda, MD 20892","Duke University, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Duke University, Durham, NC,","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9545,"has_fulltext":false,"cited_by_count":345,"citation_normalized_percentile":{"value":0.99056673,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"103","issue":"18","first_page":"7159","last_page":"7164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin-signaling","display_name":"vasopressin signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/aquaporin-2","display_name":"aquaporin-2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/kidney-collecting-duct","display_name":"renal collecting duct","score":0.6399999856948853},{"id":"https://openalex.org/keywords/inner-medullary-collecting-duct-cells","display_name":"inner medullary collecting duct cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.7910000085830688},{"id":"https://openalex.org/keywords/urea-transporter","display_name":"urea transporter","score":0.8109999895095825},{"id":"https://openalex.org/keywords/calyculin-a","display_name":"calyculin A","score":0.7580000162124634},{"id":"https://openalex.org/keywords/aqp2-trafficking","display_name":"AQP2 trafficking","score":0.7369999885559082},{"id":"https://openalex.org/keywords/bclaf1","display_name":"BCLAF1","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/label-free-quantification","display_name":"label-free quantification","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.8677229285240173},{"id":"https://openalex.org/C85562759","wikidata":"https://www.wikidata.org/wiki/Q14902527","display_name":"Aquaporin 2","level":4,"score":0.8371356725692749},{"id":"https://openalex.org/C2779933727","wikidata":"https://www.wikidata.org/wiki/Q7187535","display_name":"Phosphopeptide","level":3,"score":0.8282252550125122},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7513747811317444},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6951842308044434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5659894943237305},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.5564723014831543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4731282591819763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4449481964111328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3206943869590759},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.18799489736557007},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09326973557472229},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2775845273","wikidata":"https://www.wikidata.org/wiki/Q7973466","display_name":"Water channel","level":3,"score":0.0},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0600895103","doi":"https://doi.org/10.1073/pnas.0600895103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0600895103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16641100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16641100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1459033","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1459033/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1459033","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1459033/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3457372043","display_name":"Solute And Water Transport In Renal Epithelia","funder_award_id":"Z01HL001285","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G455837676","display_name":null,"funder_award_id":"ZO1-HL001285","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4705346009","display_name":null,"funder_award_id":"Z99 HL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W16674111","https://openalex.org/W1552784036","https://openalex.org/W1876627625","https://openalex.org/W1967001670","https://openalex.org/W1971584376","https://openalex.org/W1973638188","https://openalex.org/W1980930563","https://openalex.org/W1985475405","https://openalex.org/W1987560107","https://openalex.org/W1988009064","https://openalex.org/W1989738506","https://openalex.org/W1990042147","https://openalex.org/W1993379452","https://openalex.org/W2002378020","https://openalex.org/W2013931283","https://openalex.org/W2016955301","https://openalex.org/W2037392871","https://openalex.org/W2052074490","https://openalex.org/W2057251406","https://openalex.org/W2068111737","https://openalex.org/W2074936851","https://openalex.org/W2081042998","https://openalex.org/W2083555181","https://openalex.org/W2088243842","https://openalex.org/W2094533157","https://openalex.org/W2099796069","https://openalex.org/W2101531367","https://openalex.org/W2108396129","https://openalex.org/W2112143438","https://openalex.org/W2114078055","https://openalex.org/W2118044204","https://openalex.org/W2128987420","https://openalex.org/W2129777487","https://openalex.org/W2144009346","https://openalex.org/W2144628650","https://openalex.org/W2155880596","https://openalex.org/W2166884712","https://openalex.org/W2167695736","https://openalex.org/W2184208381","https://openalex.org/W2199571582","https://openalex.org/W2275056520","https://openalex.org/W2410064233","https://openalex.org/W2422162888","https://openalex.org/W3216731846"],"related_works":["https://openalex.org/W1562492102","https://openalex.org/W3173808774","https://openalex.org/W2107115930","https://openalex.org/W2004182894","https://openalex.org/W4225331991","https://openalex.org/W2962513404","https://openalex.org/W3113441794","https://openalex.org/W2037217027","https://openalex.org/W3173632248","https://openalex.org/W4306898443"],"abstract_inverted_index":{"Protein":[0],"phosphorylation":[1,18,59,73,112,152,219],"plays":[2],"a":[3,27,48,145,227],"key":[4],"role":[5],"in":[6,9,100,154,180,196,220,226],"vasopressin":[7,22,158],"signaling":[8,225],"the":[10,167,189,203,221],"renal-collecting":[11],"duct.":[12],"Large-scale":[13],"identification":[14,61,214],"and":[15,58,105,131,136,164,175,215],"quantification":[16,140,216],"of":[17,31,39,50,71,97,141,147,169,205,217,223],"events":[19],"triggered":[20],"by":[21,46,53,62],"is":[23],"desirable":[24],"to":[25,120,156],"gain":[26],"comprehensive":[28],"systems-level":[29],"understanding":[30],"this":[32],"process.":[33],"We":[34],"carried":[35],"out":[36],"phosphoproteomic":[37],"analysis":[38,222],"rat":[40],"inner":[41,82],"medullary":[42,83],"collecting":[43,84,121],"duct":[44,85,122],"cells":[45],"using":[47],"combination":[49],"phosphopeptide":[51],"enrichment":[52],"immobilized":[54],"metal":[55],"affinity":[56],"chromatography":[57],"site":[60],"liquid":[63,206],"chromatography-mass":[64,207],"spectrometry(n)":[65,208],"neutral":[66,209],"loss":[67,210],"scanning.":[68],"A":[69,92,95],"total":[70],"714":[72],"sites":[74,113,126,193],"on":[75],"223":[76],"unique":[77],"phosphoproteins":[78],"were":[79,108,114],"identified":[80,144],"from":[81],"samples":[86],"treated":[87],"short-term":[88,157],"with":[89],"either":[90],"calyculin":[91],"or":[93],"vasopressin.":[94],"number":[96,146],"proteins":[98,118,148],"involved":[99,195],"cytoskeletal":[101],"reorganization,":[102],"vesicle":[103],"trafficking,":[104],"transcriptional":[106],"regulation":[107],"identified.":[109],"Previously":[110],"unidentified":[111],"found":[115],"for":[116,212],"membrane":[117],"essential":[119],"physiology,":[123],"including":[124],"eight":[125],"among":[127],"aquaporin-2":[128],"(AQP2),":[129],"aquaporin-4,":[130],"urea":[132],"transporter":[133],"isoforms":[134],"A1":[135],"A3.":[137],"Through":[138],"label-free":[139],"phosphopeptides,":[142],"we":[143],"that":[149,191],"significantly":[150],"changed":[151],"state":[153],"response":[155],"treatment:":[159],"AQP2,":[160],"Bclaf1,":[161],"LRRC47,":[162],"Rgl3,":[163],"SAFB2.":[165],"In":[166],"presence":[168],"vasopressin,":[170],"AQP2":[171,177,183,198],"monophosphorylated":[172,184],"at":[173,185],"S256":[174],"diphosphorylated":[176],"(pS256/261)":[178],"increased":[179],"abundance,":[181],"whereas":[182],"S261":[186],"decreased,":[187],"raising":[188],"possibility":[190],"both":[192],"are":[194],"vasopressin-dependent":[197],"trafficking.":[199],"This":[200],"study":[201],"reveals":[202],"practicality":[204],"scanning":[211],"large-scale":[213],"protein":[218],"cell":[224],"native":[228],"mammalian":[229],"system.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}