{"id":"https://openalex.org/W2005122657","doi":"https://doi.org/10.3389/fnins.2014.00407","title":"The mitochondrial L-lactate dehydrogenase affair","display_name":"The mitochondrial L-lactate dehydrogenase affair","publication_year":2014,"publication_date":"2014-12-09","ids":{"openalex":"https://openalex.org/W2005122657","doi":"https://doi.org/10.3389/fnins.2014.00407","mag":"2005122657","pmid":"https://pubmed.ncbi.nlm.nih.gov/25538557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260494"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2014.00407","doi":"https://doi.org/10.3389/fnins.2014.00407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2014.00407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2014.00407/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2014.00407/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020805217","display_name":"Salvatore Passarella","orcid":"https://orcid.org/0000-0001-7322-015X","observed_orcids":["https://orcid.org/0000-0001-7322-015X"]},"institutions":[{"id":"https://openalex.org/I129627893","display_name":"University of Molise","ror":"https://ror.org/04z08z627","country_code":"IT","type":"education","lineage":["https://openalex.org/I129627893"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Salvatore Passarella","raw_affiliation_strings":["Department of Medicine and Health Sciences, University of Molise Campobasso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Health Sciences, University of Molise Campobasso, Italy","institution_ids":["https://openalex.org/I129627893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065246027","display_name":"Gianluca Paventi","orcid":"https://orcid.org/0000-0003-3673-0091","observed_orcids":["https://orcid.org/0000-0003-3673-0091"]},"institutions":[{"id":"https://openalex.org/I129627893","display_name":"University of Molise","ror":"https://ror.org/04z08z627","country_code":"IT","type":"education","lineage":["https://openalex.org/I129627893"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Paventi","raw_affiliation_strings":["Department of Medicine and Health Sciences, University of Molise Campobasso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Health Sciences, University of Molise Campobasso, Italy","institution_ids":["https://openalex.org/I129627893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026475636","display_name":"Roberto Pizzuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129627893","display_name":"University of Molise","ror":"https://ror.org/04z08z627","country_code":"IT","type":"education","lineage":["https://openalex.org/I129627893"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Pizzuto","raw_affiliation_strings":["Department of Medicine and Health Sciences, University of Molise Campobasso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Health Sciences, University of Molise Campobasso, Italy","institution_ids":["https://openalex.org/I129627893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020805217"],"corresponding_institution_ids":["https://openalex.org/I129627893"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.5024,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.80986801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"407","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.5540000200271606},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.3319999873638153},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lactate-metabolism","display_name":"lactate metabolism","score":0.4790000021457672},{"id":"https://openalex.org/keywords/neuroenergetics","display_name":"neuroenergetics","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5615134835243225},{"id":"https://openalex.org/C2776319529","wikidata":"https://www.wikidata.org/wiki/Q3869349","display_name":"NADH dehydrogenase","level":4,"score":0.4478890001773834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4287859797477722},{"id":"https://openalex.org/C2909544887","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"L-Lactate dehydrogenase","level":4,"score":0.41778406500816345},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.3236023783683777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2764793038368225},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14151275157928467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06990310549736023}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fnins.2014.00407","doi":"https://doi.org/10.3389/fnins.2014.00407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2014.00407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2014.00407/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3239983","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4260494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:25538557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25538557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimol.it:11695/48725","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11695/48725","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2014.00407/pdf","source":{"id":"https://openalex.org/S7407055127","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi del Molise","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:848701c8c0e0408381574e15b9c816b0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/848701c8c0e0408381574e15b9c816b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 8 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2014.00407","doi":"https://doi.org/10.3389/fnins.2014.00407","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2014.00407","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2014.00407/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005122657.pdf","grobid_xml":"https://content.openalex.org/works/W2005122657.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1551653316","https://openalex.org/W1616394907","https://openalex.org/W1819285150","https://openalex.org/W1976613901","https://openalex.org/W1976833922","https://openalex.org/W1988714133","https://openalex.org/W1997779800","https://openalex.org/W2008027515","https://openalex.org/W2016087008","https://openalex.org/W2025935630","https://openalex.org/W2032802983","https://openalex.org/W2033869532","https://openalex.org/W2044523475","https://openalex.org/W2091444961","https://openalex.org/W2092195115","https://openalex.org/W2095285518","https://openalex.org/W2127561960","https://openalex.org/W2137211226","https://openalex.org/W2142522488","https://openalex.org/W2142884473","https://openalex.org/W2155381968","https://openalex.org/W2162878563","https://openalex.org/W2164874252","https://openalex.org/W2170994089","https://openalex.org/W2239366520","https://openalex.org/W2340501659","https://openalex.org/W2433138236","https://openalex.org/W2486291840"],"related_works":["https://openalex.org/W1976613901","https://openalex.org/W1586471570","https://openalex.org/W2083246981","https://openalex.org/W3176442146","https://openalex.org/W2125035313","https://openalex.org/W2086277520","https://openalex.org/W2092195115","https://openalex.org/W2127561960","https://openalex.org/W2979069276","https://openalex.org/W2519338564"],"abstract_inverted_index":{"The":[0,84,315,576,750,1527],"existence":[1,46,73,700,890,1195,1339,1452,1584],"of":[2,47,78,112,229,275,286,302,333,339,371,378,387,390,429,434,456,500,509,513,586,606,612,647,657,667,679,701,708,723,726,754,759,798,807,818,821,843,891,903,912,1026,1043,1065,1146,1160,1196,1250,1264,1273,1294,1345,1353,1364,1424,1440,1453,1470,1485,1499,1514,1523,1529,1544,1554,1561,1585,1629,1642,1652,1671,1745,1773,1799,1809,1898,1958],"a":[3,110,181,249,353,358,385,498,598,665,677,709,724,950,983,1024,1157,1177,1271,1326,1333,1365,1454,1559,1566,1648,1697,1889,1938],"mitochondrial":[4,28,260,276,394,402,439,464,777,850,937,951,1321,1366,1408,1460,1586,1691,1717,1782,1959,2013],"L-lactate":[5,95,230,270,280,296,326,349,364,391,435,461,533,566,607,621,668,680,702,712,778,788,809,847,908,947,1027,1095,1473,1486,1630,1672,1707,1768,1803,1827,1869,1891,1926,1975,2047],"dehydrogenase":[6,1115],"(m-L-LDH)":[7],"suggested":[8,1757],"by":[9,17,61,76,198,415,481,497,615,635,644,1089,1259,1438,1466,1536,1569,1600,1777,2049],"Dianzani":[10],"et":[11,32,65,117,121,126,131,137,141,147,152,159,163,171,175,203,207,211,215,221,312,423,573,762,767,812,1034,1072,1244,1357,1373,1386,1617,1622,1677,1759,1855,1907,2021],"al.,":[12,33,66,118,122,127,132,138,153,160,164,172,176,204,208,212,216,222,313,424,574,763,813,1035,1073,1245,1358,1374,1387,1760,1908],"in":[13,26,41,53,80,237,241,248,298,352,374,474,519,552,751,792,848,855,906,919,934,990,1003,1008,1047,1081,1136,1143,1154,1181,1217,1242,1280,1292,1318,1332,1335,1390,1405,1429,1457,1481,1520,1531,1551,1663,1689,1700,1708,1713,1733,1764,1872,1884,1894,1930,1944,1961,1970,2004,2009],"1951,":[14],"was":[15,49,262,1329,1340,1369,1382,2044,2054],"shown":[16,558,772,1371,1904],"Baba":[18],"and":[19,40,56,68,93,105,166,246,273,336,450,491,538,565,589,655,670,707,747,758,773,835,852,867,885,996,1007,1069,1102,1113,1175,1214,1253,1503,1620,1710,1719,1747,1781,1812,1868,1914,1916,1934,1967,1992,2051,2069],"Sharma":[20],"(1971)":[21],"with":[22,297,554,686,782,787,922,992,1131,1247,1283,1426,1435,1444,1491,1504,1795],"the":[23,27,36,42,45,81,187,232,284,294,303,331,334,337,372,375,379,388,393,406,409,417,427,438,441,454,463,504,507,510,514,520,522,532,535,584,592,630,636,699,721,744,755,776,793,805,822,841,856,889,898,923,935,943,955,958,973,1012,1017,1041,1048,1082,1132,1151,1161,1182,1194,1212,1248,1290,1319,1337,1349,1362,1379,1398,1401,1406,1451,1458,1468,1476,1492,1497,1500,1505,1515,1524,1537,1562,1570,1583,1601,1627,1640,1653,1669,1690,1714,1722,1726,1736,1771,1774,1796,1805,1821,1885,1895,1921,1945,1955,2012,2025],"enzyme":[24,288,881,1911],"located":[25,193,470,1317,1404,1893],"matrix;":[29],"later":[30,1370],"Brooks":[31,69],"(1999)":[34],"proposed":[35,1924],"intracellular":[37],"lactate":[38],"shuttle":[39,757],"third":[43],"millennium":[44],"m-L-LDH":[48,79,192,233,468,633,706,892,926,1114,1197,1276,1315,1338,1402,1455,1686,1763],"definitively":[50,1192],"been":[51,107,550,771,917,1109,1903],"confirmed":[52,1535],"mammalian,":[54],"plant":[55,150],"yeast":[57],"mitochondria":[58,98,113,195,238,570,618,683,731,965,1032,1062,1090,1172,1425,1488,1552,1610,1635,1709,1735,1847,1873,1901,1984,2050,2064],"as":[59,384,493,495,641,643,664,676,1023,1198,1200,1241,1270,1289,1927,1937,1965,2008],"reviewed":[60],"Schurr":[62,1800],"(2006),":[63],"Passarella":[64,140,311,422],"(2008)":[67],"(2009),":[70],"being":[71],"its":[72,1099,1201],"finally":[74,1720],"recognized":[75,1568],"inclusion":[77],"Mitocarta":[82],"(http://www.broadinstitute.org/pubs/MitoCarta/index.html).":[83],"experimental":[85,1162],"strategy":[86,267,914],"to":[87,90,99,109,257,283,343,392,459,487,528,620,682,691,719,733,790,825,942,957,979,1019,1029,1040,1051,1060,1085,1093,1098,1118,1127,1149,1309,1396,1419,1449,1474,1487,1510,1540,1632,1647,1673,1682,1696,1706,1826,1830,1850,1865,1870,1878,1881,1920,1948,1997,2038,2058],"be":[88,100,235,255,445,479,517,526,650,661,717,816,873,1038,1463,1704,1816,1879,1918,1980,1986,1995,2032,2036],"used":[89,256,527,690,1050,1084,1134,1180,1996],"show":[91,698,720,804,1184],"whether":[92,531],"how":[94],"can":[96,234,292,327,444,516,582,716,872,887,1462,1815],"enter":[97,328,1061],"metabolized":[101,366],"is":[102,180,196,365,469,578,595,780,932,948,970,986,1058,1091,1125,1164,1167,1205,1278,1307,1316,1394,1403,1417,1534,1636,1739,1750,1804,1828,1835,1863,1942,1977],"well":[103,494,642,1199],"established":[104,1170,1465],"has":[106,549,770,915,940,1108,1902],"applied":[108,226,918],"variety":[111,499,725],"including":[114,447],"heart":[115],"(Brooks":[116,125],"1999,":[119,128],"Valenti":[120],"2002),":[123],"liver":[124,569,1900],"de":[129,145,765],"Bari":[130,146,170,572,766,1906],"2004),":[133],"skeletal":[134,963,993,1030,1054],"muscle":[135,964,994,1031,1055,1204],"(Dubouchaud":[136],"2000,":[139],"al":[142,1856,2022],".,":[143],"2008,":[144],"al.":[148,1618,1623,1678],"2008)":[149,1936],"(Paventi":[151],"2006),":[154],"brain":[155,1734],"(Schurr":[156],"2006,":[157],"Atlante":[158],"2007,":[161,217,219],"Hashimoto":[162],"2008),":[165],"cancer":[167,2010],"cells":[168,1883,1963,2007],"(de":[169,571,1905],"2010a,":[173],"Pizzuto":[174,1854],"2012).":[177,1857,2023],"Thus":[178,1389],"it":[179,1124,1393,1665,1693,1814,2043],"matter":[182],"for":[183,190,877,1135,1256,1725,1848,1925,2076],"considerable":[184],"surprise":[185],"that":[186,259,325,348,363,401,426,433,467,559,579,625,775,828,900,925,946,971,985,997,1111,1171,1261,1314,1352,1361,1400,1550,1609,1662,1684,1732,1744,1748,1762,1802,1813,1888,1941,2003,2046],"overwhelming":[188],"evidence":[189,324,956],"an":[191,287,397,687,1521,1542,1874],"inside":[194,367,405,471,730,1634,1657,1818],"not":[197,263,859,929,949,977,1000,1330,1589,1637,1974,2017,2055,2066],"now":[199],"universally":[200],"accepted":[201],"(Rasmussen":[202,1356],"2002,":[205,209,764],"Sahlin":[206,1616,1676],"Ponsot":[210],"2005,":[213],"Yoshida":[214],"Gladden":[218],"Elustondo":[220],"2013,).":[223],"Using":[224],"correctly":[225],"procedures,":[227],"metabolism":[228,403,704,779,810,842,1783,1976,2030,2053],"via":[231,408,705,740,801,1432,1446,1753],"investigated":[236,446],"(but":[239],"also":[240,662],"permeabilized":[242],"cells,":[243,2011],"cell":[244],"homogenates":[245],"mitoplasts)":[247],"few":[250],"hours.":[251],"Obviously,":[252],"caution":[253],"must":[254,649],"control":[258,418,1107],"coupling":[261],"impaired.":[264],"This":[265,737,939,1910],"simple":[266,1178,1327,1593],"includes":[268],"both":[269,587,1615],"uptake":[271,281,350,585,669,674,1088,1096,2048],"measurements":[272,274,316,320],"processes":[277],"occurring":[278,784],"after":[279,1210,1296],"due":[282,342,619,732,1039,1097,1539,2057],"occurrence":[285,806,1363],"i.e.":[289,1929],"m-L-LDH,":[290],"which":[291,321,603,1336,1442,1495,1701,1971],"metabolize":[293],"imported":[295],"some":[299,308,546],"cases":[300,547],"export":[301],"newly":[304,728,1516],"synthesized":[305,729],"metabolites":[306,727,800],"(for":[307],"details":[309],"see":[310,1853],"2003).":[314],"include:":[317],"1.":[318],"Swelling":[319],"provide":[322,1866],"initial":[323,878],"mitochondria;":[329,1658],"importantly,":[330],"stereospecificity":[332],"process":[335,1533],"inhibition":[338,523,605,634,1538],"swelling":[340],"found":[341,383,663],"non-penetrant":[344,501],"compounds":[345,1147],"strongly":[346],"suggest":[347,1683],"occurs":[351,404,675,1269,1304,1414],"carrier":[354,537,594,1778,2015],"mediated":[355,1779],"manner.":[356],"Obviously":[357],"carrier-mediated":[359],"transport":[360,436,442,460,515,563,608,1728,1780],"itself":[361,399],"suggests":[362,774],"mitochondria.":[368,472,1819,2041],"2.":[369,1450],"Measurements":[370,611,715],"increase":[373,398,656,834,1522],"redox":[376,476,1655],"state":[377,477],"intramitochondrial":[380,808,1066,1477,1501,2052],"pyridine":[381],"nucleotides":[382],"result":[386,666,678,1025,1272],"addition":[389,681,1028,1298,1439,1484],"samples;":[395],"such":[396,1325,1964],"shows":[400,1549],"organelles":[407],"NAD+":[410,430,631,1478,1737],"dependent":[411,632],"m-L-LDH.":[412,1447],"Having":[413],"established,":[414],"applying":[416],"strength":[419],"criterion":[420],"(see":[421,2061],"2003),":[425],"rate":[428,1436],"reduction":[431,1263,1651],"mirrors":[432],"across":[437,462],"membrane,":[440],"kinetics":[443,882],"their":[448,1257,1596],"pH":[449,1235],"temperature":[451],"dependence.":[452],"Importantly":[453],"presence":[455,1042],"carrier/s":[457,803],"devoted":[458],"membrane":[465,658],"postulates":[466],"Changes":[473],"NAD+/NADH":[475,1654],"should":[478,1979,1985,2035],"modulated":[480],"certain":[482,799],"ionophores":[483],"under":[484],"conditions":[485,1163],"designed":[486],"selectively":[488],"affect":[489,1150],"\u0394pH":[490],"\u0394\u03a8":[492,833],"inhibited":[496,596],"compounds.":[502],"In":[503,545,960,1376,1788,1858],"former":[505],"case":[506,962,1378,1483,1860],"nature":[508],"energy":[511,694,703],"dependence":[512],"established;":[518],"latter":[521],"profiles":[524],"could":[525,660,738,815,1037,1917,1994],"ascertain":[529,1193],"further":[530,1952,2077],"carriers,":[534],"pyruvate":[536,564,588,593,748,791,823,844,1297,1306,1354,1367,1416,1441,1633,1674,1702,1749,1754,1915,1972,2000,2014,2029],"other":[539,920,1579,1822,1840,1882,2026],"carriers":[540,562],"differ":[541],"from":[542,743,840,846,988],"one":[543,2034],"another.":[544],"this":[548,913,961,1312,1482,1532,1789,1859],"shown:":[551],"distinction":[553],"others":[555],"we":[556,1756],"have":[557,897],"two":[560],"separate":[561,742],"into":[567,1954],"rat":[568,1899],"2004).":[575],"point":[577,1646],"\u03b1\u2212cyano-hydroxy-cinnamate":[580],"(\u03b1-CCN-)":[581],"inhibit":[583],"L-lactate,":[590,745],"but":[591,858,896,1973,2063],"at":[597,602,1011,1266,1626],"concentration":[599,1738],"(25":[600],"\u03bcM)":[601],"no":[604,904,1106,1262,1411],"occurs.":[609],"3.":[610],"oxygen":[613,626,829,1021,1087],"consumption":[614,627,1022],"coupled":[616,981],"purified":[617,1174,1420],"addition.":[622,1275],"To":[623,1950],"conclude":[624],"depends":[628],"on":[629,1605,1639,1681],"complex":[637,1506],"1":[638,1229,1232,1434],"inhibitor":[639,688,820,1508,1543],"rotenone":[640,1509],"oxalate/oxamate,":[645],"inhibitors":[646,1010],"L-LDH":[648,1346,1380,1530,1571,1587,1960],"found.":[651],"4.":[652],"Proton":[653],"efflux":[654,722,797,1064],"potential":[659],"metabolism.":[671,695,909,2001],"Conversely":[672],"proton":[673,710,831],"previously":[684],"treated":[685,1490],"cocktail":[689],"prevent":[692,1094,1511,1998],"any":[693,1512,1785,1999],"These":[696],"effects":[697],"compensated":[711],"symport.":[713],"5.":[714],"made":[718,817],"externally":[734,1471],"added":[735,1308,1418,1472],"L-lactate.":[736,1613],"occur":[739,1831,1851],"antiporters,":[741],"D-lactate":[746],"carriers.":[749],"vitro":[752,1137],"reconstruction":[753],"L-lactate/pyruvate":[756],"gluconeogenesis":[760,783],"(Valenti":[761],"al,":[768],"2004)":[769],"associated":[781],"perhaps":[785,972],"together":[786],"oxidation":[789,1413,1431,1498,1513,1775,1825],"cytosol.":[794],"However":[795,1730],"even":[796,893],"unidentified":[802],"(Pizzuto":[811,1372,2020],"2012).Use":[814],"arsenite,":[819],"dehydrogenase,":[824,1755],"rule":[826],"out":[827,1591],"consumption,":[830],"efflux,":[832],"metabolite":[836,952],"traffic":[837],"derives":[838],"solely":[839],"generated":[845],"external":[849],"compartments":[851,1461],"taken":[853],"up":[854,2071],"matrix.Last,":[857],"least,":[860],"a)":[861,875],"enzymatic":[862],"assay":[863,1328],"b)":[864,884],"immunological":[865,1547],"analysis":[866,1548],"c)":[868,886],"confocal":[869],"fluorescence":[870],"microscopy":[871],"used:":[874],"allows":[876],"information":[879],"about":[880],"features;":[883],"reveal":[888],"if":[894,1140,1188,1685,2028],"inactive,":[895],"limitation":[899],"they":[901,998],"are":[902,1116,1173,1239,1598,1844,2074],"value":[905],"dissecting":[907],"A":[910],"part":[911],"unsuccessfully":[916],"laboratories":[921],"conclusion":[924,945],"either":[927],"does":[928,2016],"exist":[930],"or":[931],"localized":[933,1456],"outer":[936,1407],"compartments.":[938,1322],"led":[941],"mistaken":[944,1602],"despite":[953],"all":[954],"contrary.":[959],"were":[966,976,999,1687,1793],"investigated.":[967],"Our":[968],"opinion":[969,1166,1392],"investigators":[974,1580],"concerned":[975],"able":[978],"isolate":[980],"mitochondria,":[982,1152,1311,1421],"task":[984],"far":[987],"easy":[989,1395],"particular":[991],"samples,":[995],"careful":[1001],"enough":[1002],"selecting":[1004],"reaction":[1005],"media":[1006],"using":[1009],"right":[1013],"concentrations.":[1014],"For":[1015],"instance":[1016],"failure":[1018],"measure":[1020,1086],"(Elustondo":[1033],"2013)":[1036],"5":[1044,1226],"mM":[1045,1078,1120,1224,1227,1230,1233],"MgSO4":[1046],"medium":[1049,1083,1133,1144,1156,1220],"prepare":[1052],"isolated":[1053,1207,1240,2040],"mitochondria:":[1056],"sulphate":[1057],"known":[1059],"causing":[1063],"phosphate,":[1067],"malate":[1068],"succinate":[1070],"(Crompton":[1071],"1974,":[1074],"1975).":[1075],"Moreover":[1076],"60":[1077,1119],"lactobionate":[1079],"included":[1080],"expected":[1092,1148,1829,1864],"chemical":[1100],"structure":[1101],"high":[1103],"concentration.":[1104],"Finally,":[1105],"reported":[1110,1331],"c":[1112],"insensitive":[1117],"lactobionate.":[1121],"Of":[1122],"course,":[1123],"impossible":[1126],"mimic":[1128],"cytosol":[1129],"totally":[1130],"experiments,":[1138],"however":[1139],"findings":[1141],"observed":[1142],"free":[1145,1553],"\u201cdisappear\u201d":[1153],"another":[1155,1377],"detailed":[1158],"examination":[1159],"needed.Our":[1165],"that,":[1168],"having":[1169],"coupled,":[1176],"protocol,":[1179],"experiment":[1183],"here":[1185],"(Fig.":[1186,1299,1479],"1),":[1187],"properly":[1189,2019],"followed":[1190],"will":[1191],"localization.Rabbit":[1202],"gastrocnemius":[1203],"rapidly":[1206],"(5-10":[1208],"min)":[1209],"killing":[1211],"animals":[1213],"put":[1215],"immediately":[1216,1254],"ice-cold":[1218],"KCl":[1219],"(0.1":[1221],"KCl,":[1222],"50":[1223],"Tris-HCl,":[1225],"MgCl2,":[1228],"EDTA,":[1231],"ATP,":[1234],"7.5).":[1236],"Mitochondria":[1237],"(RGM)":[1238],"(Lee":[1243],"1993)":[1246],"exclusion":[1249],"protease":[1251],"treatment":[1252,1423],"checked":[1255],"intactness":[1258],"showing":[1260,1313],"absorbance":[1265,1293,1302],"334":[1267],"nm":[1268],"NADH":[1274,1295,1412,1430,1445,1718,1746],"activity":[1277,1347,1381],"assayed":[1279],"RGM":[1281],"solubilized":[1282],"0.1":[1284],"%":[1285],"Triton":[1286],"X-100":[1287],"(TX-100)":[1288],"decrease":[1291],"1A).":[1300],"No":[1301],"change":[1303],"when":[1305,1415,1832],"intact":[1310,1962],"inner":[1320,1459],"Surprisingly":[1323],"enough,":[1324],"paper":[1334],"denied":[1341],"since":[1342,1837],"\u201cthe":[1343],"distribution":[1344],"among":[1348],"fractions":[1350],"paralleled":[1351],"kinase\u201d":[1355],"2002);":[1359],"notice":[1360],"kinase":[1368],"2010).":[1375],"considered":[1383],"negligible":[1384],"(Yoshida":[1385],"2007).":[1388],"our":[1391,1791],"dismiss":[1397],"possibility":[1399,1670],"membrane/intermembrane":[1409],"space:":[1410],"whereas":[1422],"TX-100":[1427],"results":[1428,1519,1792],"Complex":[1433],"increased":[1437],"reacts":[1443],"According":[1448],"simply":[1464],"checking":[1467],"ability":[1469],"reduce":[1475],"1B);":[1480],"(previously":[1489],"uncoupler":[1493],"FCCP,":[1494],"favours":[1496],"NADH,":[1502],"I":[1507],"formed":[1517],"NADH)":[1518],"NAD(P)H":[1525],"fluorescence.":[1526],"involvement":[1528],"oxamate,":[1541],"LDH.":[1545],"Consistently,":[1546],"cytosolic":[1555,1563],"contamination":[1556],"(no":[1557],"tubulin,":[1558],"marker":[1560],"fraction)":[1564],"contains":[1565],"protein":[1567],"antibody":[1572],"(inset":[1573],"Fig.":[1574],"1).":[1575],"We":[1576,2073],"wonder":[1577],"why":[1578],"who":[1581],"deny":[1582],"did":[1588,2065],"carry":[1590],"these":[1592],"experiments.":[1594],"Perhaps":[1595],"views":[1597],"coloured":[1599],"belief,":[1603],"based":[1604],"incorrect":[1606],"thermodynamic":[1607,1643,1786],"arguments,":[1608],"cannot":[1611,2031],"import":[1612],"Indeed":[1614],"(2002)":[1619,1624,1679],"Rasmussen":[1621],"argue":[1625],"idea":[1628],"conversion":[1631],"feasible":[1638],"basis":[1641],"principles.":[1644],"They":[1645],"much":[1649,1660],"higher":[1650,1661,1742],"couple":[1656],"so":[1659],"fact":[1664],"would":[1666,1694,1703],"theoretically":[1667],"eliminate":[1668],"conversion.":[1675],"go":[1680],"present":[1688],"matrix,":[1692],"lead":[1695],"futile":[1698],"cycle":[1699,1842],"reduced":[1705,1836],"vice":[1711],"versa":[1712],"cytosol,":[1715],"oxidizing":[1716],"removing":[1721],"driving":[1723],"force":[1724],"electron":[1727],"chain.":[1729],"given":[1731],"8\u201320":[1740],"fold":[1741],"than":[1743],"actively":[1751],"oxidized":[1752],"(Atlante":[1758],"2007)":[1761],"vivo":[1765],"catalyses":[1766],"essentially":[1767],"oxidation.":[1769],"Ultimately,":[1770],"removal":[1772],"product":[1776,1808],"overcomes":[1784],"difficulty.":[1787],"case,":[1790],"consistent":[1794],"postulate/":[1797],"proposal":[1798],"(2006)":[1801],"only":[1806],"major":[1807],"cerebral":[1810],"glycolysis":[1811,1862],"metabolised":[1817],"On":[1820,2024],"hand":[1823],"glucose":[1824],"oxidative":[1833],"phosphorylation":[1834],"citrate":[1838],"and/or":[1839,1877],"citric":[1841],"intermediates":[1843],"required":[1845],"outside":[1846],"anabolism":[1849],"(e.g.":[1852],"anaerobic":[1861],"ATP":[1867],"play":[1871],"anaplerotic":[1875],"role":[1876,1923,1957],"transferred":[1880],"intercellular":[1886],"shuttle.Notice":[1887],"putative":[1890],"oxidase,":[1892],"intermembrane":[1896],"space":[1897],"2010b).":[1909],"gives":[1912],"H2O2":[1913],"candidate":[1919],"new":[1922],"\u201clactormone\u201d.":[1928],"Brooks\u2019":[1931],"term":[1932],"(Hashimoto":[1933],"Brooks,":[1935],"cell-signalling":[1939],"molecule":[1940],"involved":[1943],"adaptive":[1946],"response":[1947],"exercise.":[1949],"gain":[1951],"insight":[1953],"physiological":[1956],"neurons":[1966],"myocytes,":[1968],"experiments":[1969],"prevented":[1978,2033],"carried":[1981],"out,":[1982],"otherwise":[1983],"used.":[1987],"Likely":[1988],"low":[1989],"\u03b1-cyanocinnamate":[1990],"concentrations":[1991],"arsenite":[1993],"Notice":[2002],"Hep":[2005],"G2":[2006],"work":[2018],"hand,":[2027],"forced":[2037],"use":[2039],"Indeed,":[2042],"claimed":[2045],"feasible,":[2056],"thermodynamics":[2059],"reasons":[2060],"above),":[2062],"know":[2067],"this\u2026":[2068],"took":[2070],"L-lactate!":[2072],"waiting":[2075],"progress!":[2078]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
