{"id":"https://openalex.org/W2005117549","doi":"https://doi.org/10.1016/j.pharmthera.2009.10.001","title":"De-regulated FGF receptors as therapeutic targets in cancer","display_name":"De-regulated FGF receptors as therapeutic targets in cancer","publication_year":2009,"publication_date":"2009-10-28","ids":{"openalex":"https://openalex.org/W2005117549","doi":"https://doi.org/10.1016/j.pharmthera.2009.10.001","mag":"2005117549","pmid":"https://pubmed.ncbi.nlm.nih.gov/19874848"},"language":"en","primary_location":{"id":"doi:10.1016/j.pharmthera.2009.10.001","doi":"https://doi.org/10.1016/j.pharmthera.2009.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2009.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005117549"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046596823","display_name":"Victoria Knights","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Knights","raw_affiliation_strings":["Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, England, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025815250","display_name":"Simon J. Cook","orcid":"https://orcid.org/0000-0001-9087-1616","observed_orcids":["https://orcid.org/0000-0001-9087-1616"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Simon J. Cook","raw_affiliation_strings":["Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, England, UK","institution_ids":["https://openalex.org/I1302113299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025815250"],"corresponding_institution_ids":["https://openalex.org/I1302113299"],"apc_list":{"value":5660,"currency":"USD","value_usd":5660},"apc_paid":null,"fwci":1.2776,"has_fulltext":false,"cited_by_count":201,"citation_normalized_percentile":{"value":0.78523985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"125","issue":"1","first_page":"105","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6029999852180481},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oncogene-addiction","display_name":"oncogene addiction","score":0.671999990940094},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.7982268333435059},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.7915385961532593},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6689955592155457},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6171435713768005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6148021817207336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5785567760467529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5589218735694885},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4913860857486725},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46446627378463745},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4531923830509186},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3940966725349426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23901009559631348},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10948801040649414}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pharmthera.2009.10.001","doi":"https://doi.org/10.1016/j.pharmthera.2009.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2009.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:19874848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19874848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W17441187","https://openalex.org/W61795934","https://openalex.org/W1541491219","https://openalex.org/W1543268153","https://openalex.org/W1546577360","https://openalex.org/W1563019250","https://openalex.org/W1600771042","https://openalex.org/W1648611455","https://openalex.org/W1854803455","https://openalex.org/W1913097128","https://openalex.org/W1940527094","https://openalex.org/W1941585788","https://openalex.org/W1954161036","https://openalex.org/W1958742527","https://openalex.org/W1963557114","https://openalex.org/W1963713713","https://openalex.org/W1965887467","https://openalex.org/W1970341138","https://openalex.org/W1970899833","https://openalex.org/W1970908631","https://openalex.org/W1972078693","https://openalex.org/W1976543333","https://openalex.org/W1977062527","https://openalex.org/W1978802056","https://openalex.org/W1980738750","https://openalex.org/W1983833034","https://openalex.org/W1984145333","https://openalex.org/W1986790385","https://openalex.org/W1987033227","https://openalex.org/W1989444680","https://openalex.org/W1990338764","https://openalex.org/W1990738177","https://openalex.org/W1993860023","https://openalex.org/W1994664175","https://openalex.org/W1998971866","https://openalex.org/W2001853125","https://openalex.org/W2005909927","https://openalex.org/W2006282831","https://openalex.org/W2007466764","https://openalex.org/W2015852145","https://openalex.org/W2016396075","https://openalex.org/W2018542248","https://openalex.org/W2021703617","https://openalex.org/W2024324841","https://openalex.org/W2027239974","https://openalex.org/W2027684265","https://openalex.org/W2030500412","https://openalex.org/W2031541885","https://openalex.org/W2034269086","https://openalex.org/W2035280941","https://openalex.org/W2038217206","https://openalex.org/W2045951959","https://openalex.org/W2047476474","https://openalex.org/W2047510068","https://openalex.org/W2049903695","https://openalex.org/W2050252881","https://openalex.org/W2052380264","https://openalex.org/W2054399333","https://openalex.org/W2056983875","https://openalex.org/W2059192510","https://openalex.org/W2063874384","https://openalex.org/W2064283997","https://openalex.org/W2065628269","https://openalex.org/W2066059461","https://openalex.org/W2066998725","https://openalex.org/W2068635250","https://openalex.org/W2070655784","https://openalex.org/W2073140732","https://openalex.org/W2074775218","https://openalex.org/W2076861604","https://openalex.org/W2077673213","https://openalex.org/W2077804275","https://openalex.org/W2077850223","https://openalex.org/W2080719056","https://openalex.org/W2084630860","https://openalex.org/W2086359733","https://openalex.org/W2086549703","https://openalex.org/W2087803378","https://openalex.org/W2088123597","https://openalex.org/W2088992645","https://openalex.org/W2089756110","https://openalex.org/W2089810126","https://openalex.org/W2091030555","https://openalex.org/W2091344200","https://openalex.org/W2093351885","https://openalex.org/W2094541918","https://openalex.org/W2095509444","https://openalex.org/W2096477951","https://openalex.org/W2097073373","https://openalex.org/W2097767970","https://openalex.org/W2098637021","https://openalex.org/W2099022883","https://openalex.org/W2101306957","https://openalex.org/W2103098489","https://openalex.org/W2103514020","https://openalex.org/W2106838577","https://openalex.org/W2114024312","https://openalex.org/W2115607198","https://openalex.org/W2116156965","https://openalex.org/W2116215301","https://openalex.org/W2117122875","https://openalex.org/W2117209575","https://openalex.org/W2118471405","https://openalex.org/W2120404631","https://openalex.org/W2122892477","https://openalex.org/W2126524003","https://openalex.org/W2130440144","https://openalex.org/W2135296230","https://openalex.org/W2137035181","https://openalex.org/W2138178479","https://openalex.org/W2140906178","https://openalex.org/W2141393790","https://openalex.org/W2142902504","https://openalex.org/W2143689988","https://openalex.org/W2143895308","https://openalex.org/W2144674229","https://openalex.org/W2146408581","https://openalex.org/W2147025626","https://openalex.org/W2147960762","https://openalex.org/W2148201130","https://openalex.org/W2148973479","https://openalex.org/W2157467930","https://openalex.org/W2159453741","https://openalex.org/W2162459279","https://openalex.org/W2163961175","https://openalex.org/W2165080661","https://openalex.org/W2165801057","https://openalex.org/W2167207038","https://openalex.org/W2167728561","https://openalex.org/W2169147580","https://openalex.org/W2169501865","https://openalex.org/W2170285778","https://openalex.org/W2255397267","https://openalex.org/W2273980314","https://openalex.org/W2308973955","https://openalex.org/W2321323503","https://openalex.org/W2414364002","https://openalex.org/W2415440292","https://openalex.org/W2581263511","https://openalex.org/W4237659442","https://openalex.org/W6602529276","https://openalex.org/W6632554305","https://openalex.org/W6640873795","https://openalex.org/W6683569659","https://openalex.org/W6684448578","https://openalex.org/W6684902706","https://openalex.org/W6697928590"],"related_works":["https://openalex.org/W4405968680","https://openalex.org/W2595713273","https://openalex.org/W2157467930","https://openalex.org/W1776781495","https://openalex.org/W2909086976","https://openalex.org/W2113727201","https://openalex.org/W2050244095","https://openalex.org/W3092415819","https://openalex.org/W2098466520","https://openalex.org/W1988476050"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}