{"id":"https://openalex.org/W2005117212","doi":"https://doi.org/10.2174/1568006054553426","title":"Drug Eluting Stents in Interventional Cardiology - Current Evidence and Emerging Uses","display_name":"Drug Eluting Stents in Interventional Cardiology - Current Evidence and Emerging Uses","publication_year":2005,"publication_date":"2005-07-28","ids":{"openalex":"https://openalex.org/W2005117212","doi":"https://doi.org/10.2174/1568006054553426","mag":"2005117212","pmid":"https://pubmed.ncbi.nlm.nih.gov/16101564"},"language":"en","primary_location":{"id":"doi:10.2174/1568006054553426","doi":"https://doi.org/10.2174/1568006054553426","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568006054553426","pdf_url":null,"source":{"id":"https://openalex.org/S2764548042","display_name":"Cardiovascular & Haematological Disorders - Drug Targets","issn_l":"1568-0061","issn":["1568-0061","1871-529X","1875-5895","2212-4063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target -Cardiovascular & Hematological Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033249686","display_name":"Neil Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Swanson","raw_affiliation_strings":["University Hospitals of Leicester, UK. b.n.swanson@talk21.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals of Leicester, UK. b.n.swanson@talk21.com","institution_ids":["https://openalex.org/I2802445252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005053904","display_name":"AH Gershlick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Gershlick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.865,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.77476718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4","first_page":"313","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-eluting-stents","display_name":"drug-eluting stents","score":1.0},{"id":"https://openalex.org/keywords/in-stent-restenosis","display_name":"in-stent restenosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/primary-percutaneous-coronary-intervention","display_name":"primary percutaneous coronary intervention","score":0.8059999942779541},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8209999799728394},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bare-metal-stents","display_name":"bare-metal stents","score":0.7820000052452087},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.7609999775886536},{"id":"https://openalex.org/keywords/restenosis-prevention","display_name":"restenosis prevention","score":0.8629999756813049},{"id":"https://openalex.org/keywords/revascularization","display_name":"revascularization","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8982666730880737},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.8615578413009644},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7368775606155396},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7180486917495728},{"id":"https://openalex.org/C2781274984","wikidata":"https://www.wikidata.org/wiki/Q3559674","display_name":"Interventional cardiology","level":2,"score":0.7108182907104492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6681653261184692},{"id":"https://openalex.org/C2780326628","wikidata":"https://www.wikidata.org/wiki/Q539795","display_name":"Angioplasty","level":2,"score":0.5948735475540161},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5257516503334045},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.5175644755363464},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.43265509605407715},{"id":"https://openalex.org/C2777785093","wikidata":"https://www.wikidata.org/wiki/Q2032041","display_name":"Unstable angina","level":3,"score":0.4318167567253113},{"id":"https://openalex.org/C2777546689","wikidata":"https://www.wikidata.org/wiki/Q3973120","display_name":"Drug-eluting stent","level":4,"score":0.4283910393714905},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36690980195999146}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015607","descriptor_name":"Stents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023903","descriptor_name":"Coronary Restenosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1568006054553426","doi":"https://doi.org/10.2174/1568006054553426","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568006054553426","pdf_url":null,"source":{"id":"https://openalex.org/S2764548042","display_name":"Cardiovascular & Haematological Disorders - Drug Targets","issn_l":"1568-0061","issn":["1568-0061","1871-529X","1875-5895","2212-4063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target -Cardiovascular & Hematological Disorders","raw_type":"journal-article"},{"id":"pmid:16101564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16101564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug targets. Cardiovascular & haematological disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2411165960","https://openalex.org/W2208101667","https://openalex.org/W2085181824","https://openalex.org/W1760719812","https://openalex.org/W937338006","https://openalex.org/W4241772405","https://openalex.org/W2400009723","https://openalex.org/W2198271047","https://openalex.org/W2014974107","https://openalex.org/W2139396379"],"abstract_inverted_index":{"Intervention":[0],"in":[1,13,60,112,125,131,142,158,192,195,204,212,224],"coronary":[2,33,45],"artery":[3],"disease":[4],"is":[5,154,166,201],"an":[6],"area":[7,77],"of":[8,16,32,65,78,91,103,110,128,137,146,160,178,183,186,215,226],"cardiology":[9],"where":[10],"novel":[11],"drugs,":[12],"the":[14,29,86,89,100,108,126,135,143,184,213],"form":[15],"drug-eluting":[17],"stents":[18,120],"(DES),":[19],"are":[20,26,57,190],"being":[21,58],"used":[22,27],"increasingly":[23],"commonly.":[24],"DES":[25,111],"across":[28,93],"whole":[30],"range":[31],"intervention,":[34],"from":[35],"stable":[36],"angina":[37],"patients":[38],"with":[39],"single":[40],"or":[41],"multivessel":[42],"disease,":[43],"acute":[44,48,113],"syndromes":[46],"and":[47,105,117,149,176],"myocardial":[49,114,150],"infarction":[50,115],"(i.e.":[51],"primary":[52],"angioplasty).":[53],"Most":[54],"recently,":[55],"they":[56,189],"tested":[59],"a":[61,74,122,209],"particularly":[62],"challenging":[63],"subset":[64],"patients,":[66],"those":[67],"experiencing":[68],"symptoms":[69],"due":[70],"to":[71,208],"restenosis":[72,148,194,218],"within":[73],"previously":[75],"stented":[76],"vessel":[79],"(in-stent":[80],"restenosis,":[81],"ISR).":[82],"This":[83,164,199],"article":[84],"summarises":[85],"rationale":[87],"for":[88],"use":[90,127,153],"DES,":[92],"all":[94],"these":[95],"areas,":[96],"focussing":[97],"specifically":[98],"on":[99],"emerging":[101],"results":[102],"trials":[104],"registries":[106],"examining":[107],"effectiveness":[109],"(AMI)":[116],"ISR.":[118],"Drug-eluting":[119],"represent":[121],"significant":[123,203],"shift":[124],"locally-delivered":[129],"drugs":[130],"interventional":[132],"cardiology.":[133],"On":[134],"basis":[136],"encouraging":[138],"trial":[139],"data,":[140],"including":[141],"specific":[144],"areas":[145],"in-stent":[147],"infarction,":[151],"their":[152,169],"becoming":[155],"extremely":[156],"widespread":[157],"place":[159],"bare-metal":[161],"(drug-free)":[162],"stents.":[163],"change":[165],"happening":[167],"despite":[168],"high":[170],"costs,":[171],"relatively":[172],"short":[173],"follow-up":[174],"data":[175],"concerns":[177],"possible":[179],"unwanted":[180],"effects,":[181],"because":[182],"weight":[185],"evidence":[187],"that":[188],"superior":[191],"preventing":[193],"many":[196],"patient":[197],"groups.":[198],"reduction":[200],"highly":[202],"angiographic":[205],"terms":[206,225],"and,":[207],"lesser":[210],"degree,":[211],"prevention":[214],"clinically":[216],"important":[217],"requiring":[219],"revascularisation,":[220],"but":[221],"not":[222],"clearly":[223],"overall":[227],"mortality.":[228]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}