{"id":"https://openalex.org/W2005106452","doi":"https://doi.org/10.1159/000130068","title":"Chronic Inflammation and CD16+ Natural Killer Cell Zeta-Chain Downregulation in Hemodialysis Patients","display_name":"Chronic Inflammation and CD16+ Natural Killer Cell Zeta-Chain Downregulation in Hemodialysis Patients","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2005106452","doi":"https://doi.org/10.1159/000130068","mag":"2005106452","pmid":"https://pubmed.ncbi.nlm.nih.gov/18463433"},"language":"en","primary_location":{"id":"doi:10.1159/000130068","doi":"https://doi.org/10.1159/000130068","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000130068","pdf_url":null,"source":{"id":"https://openalex.org/S204618219","display_name":"Blood Purification","issn_l":"0253-5068","issn":["0253-5068","1421-9735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Purification","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005106452"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088652616","display_name":"Theodoros Eleftheriadis","orcid":"https://orcid.org/0000-0001-9302-1633","observed_orcids":["https://orcid.org/0000-0001-9302-1633"]},"institutions":[{"id":"https://openalex.org/I4210105937","display_name":"General Hospital of Serres","ror":"https://ror.org/01c5cqy87","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105937"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodoros Eleftheriadis","raw_affiliation_strings":["Nephrology Department, General Hospital of Serres, Serres, Greece. teleftheriadis@yahoo.com","Nephrology Department, General Hospital of Serres, Serres,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, General Hospital of Serres, Serres, Greece. teleftheriadis@yahoo.com","institution_ids":["https://openalex.org/I4210105937"]},{"raw_affiliation_string":"Nephrology Department, General Hospital of Serres, Serres,","institution_ids":["https://openalex.org/I4210105937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015081540","display_name":"Charalambos Kartsios","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charalambos Kartsios","raw_affiliation_strings":["Laboratory of Hematology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085826151","display_name":"Efthalia E. Yiannaki","orcid":"https://orcid.org/0000-0003-2724-2299","observed_orcids":["https://orcid.org/0000-0003-2724-2299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Efi Yiannaki","raw_affiliation_strings":["Laboratory of Hematology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030328897","display_name":"Polizo Kazila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Polizo Kazila","raw_affiliation_strings":["Laboratory of Biochemistry, Theagenion Anticancer Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Theagenion Anticancer Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041139066","display_name":"Georgia Antoniadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105937","display_name":"General Hospital of Serres","ror":"https://ror.org/01c5cqy87","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105937"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgia Antoniadi","raw_affiliation_strings":["Nephrology Department, General Hospital of Serres, Serres,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, General Hospital of Serres, Serres,","institution_ids":["https://openalex.org/I4210105937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005039126","display_name":"Vassilios Liakopoulos","orcid":"https://orcid.org/0000-0002-7564-2724","observed_orcids":["https://orcid.org/0000-0002-7564-2724"]},"institutions":[{"id":"https://openalex.org/I4210105937","display_name":"General Hospital of Serres","ror":"https://ror.org/01c5cqy87","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105937"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassilios Liakopoulos","raw_affiliation_strings":["Nephrology Department, General Hospital of Serres, Serres,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, General Hospital of Serres, Serres,","institution_ids":["https://openalex.org/I4210105937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072779688","display_name":"Dimitra Markala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitra Markala","raw_affiliation_strings":["Laboratory of Hematology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6066,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81862332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"26","issue":"4","first_page":"317","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cd16-nk-cells","display_name":"CD16+ NK cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.5220000147819519},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.879734992980957},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.5928627252578735},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5606590509414673},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5127771496772766},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5050123333930969},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5045121908187866},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4755004346370697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47318363189697266},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.3480982780456543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33812326192855835},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.31449633836746216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2861979007720947},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26797574758529663},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.23168939352035522},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06720960140228271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06658691167831421}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000130068","doi":"https://doi.org/10.1159/000130068","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000130068","pdf_url":null,"source":{"id":"https://openalex.org/S204618219","display_name":"Blood Purification","issn_l":"0253-5068","issn":["0253-5068","1421-9735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Purification","raw_type":"journal-article"},{"id":"pmid:18463433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18463433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood purification","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1965037168","https://openalex.org/W1969814796","https://openalex.org/W1970585166","https://openalex.org/W1974702882","https://openalex.org/W1979380737","https://openalex.org/W1981215438","https://openalex.org/W1983205909","https://openalex.org/W1983591605","https://openalex.org/W1986259485","https://openalex.org/W1987380247","https://openalex.org/W2017225695","https://openalex.org/W2018466091","https://openalex.org/W2020354584","https://openalex.org/W2036669264","https://openalex.org/W2038112648","https://openalex.org/W2041550075","https://openalex.org/W2046942511","https://openalex.org/W2052747333","https://openalex.org/W2055983169","https://openalex.org/W2067950819","https://openalex.org/W2075735730","https://openalex.org/W2092488874","https://openalex.org/W2098962500","https://openalex.org/W2115273248","https://openalex.org/W2134401635","https://openalex.org/W2138281334","https://openalex.org/W2147970243","https://openalex.org/W2150078273"],"related_works":["https://openalex.org/W2033192614","https://openalex.org/W2046461238","https://openalex.org/W4380448348","https://openalex.org/W2434575565","https://openalex.org/W2036904159","https://openalex.org/W2464537452","https://openalex.org/W1589144233","https://openalex.org/W4404033595","https://openalex.org/W2981259184","https://openalex.org/W2021871630"],"abstract_inverted_index":{"BACKGROUND:":[0],"Natural":[1],"killer":[2],"(NK)":[3],"cell":[4,28,48,89,125,137,157,169],"activity":[5],"is":[6,14,30,41],"decreased":[7,143,167],"in":[8,32,51,121,144,161],"hemodialysis":[9],"(HD)":[10],"patients.":[11,123],"Zeta-chain":[12],"phosphorylation":[13],"an":[15],"early":[16],"event":[17],"that":[18],"follows":[19],"the":[20,68,86,145,155,166],"triggering":[21],"of":[22,80],"some":[23],"NK":[24,27,47,82,124,136,156,168],"cell-activating":[25],"receptors.":[26],"zeta-chain":[29,49,92,138],"downregulated":[31],"patients":[33,60,132],"with":[34,98,113],"cancer":[35],"due":[36],"to":[37,78,165],"chronic":[38,44],"inflammation.":[39],"HD":[40,52,59,122,131,162],"also":[42],"a":[43],"inflammatory":[45,102,117],"state.":[46],"expression":[50],"was":[53,73,142],"evaluated.":[54],"PATIENTS":[55],"AND":[56],"METHODS:":[57],"Thirty-three":[58],"and":[61,84,91,107,133],"30":[62],"healthy":[63,134],"volunteers":[64],"were":[65,96,111,119],"enrolled":[66],"into":[67],"study.":[69],"The":[70,101,116],"CD3-CD16+":[71],"subpopulation":[72],"examined,":[74],"since":[75],"it":[76],"corresponds":[77],"90%":[79],"all":[81],"cells":[83],"has":[85],"highest":[87],"cytotoxicity.NK":[88],"count":[90,126],"mean":[93,139],"fluorescence":[94,140],"intensity":[95,141],"evaluated":[97],"flow":[99],"cytometry.":[100],"markers":[103,118],"C-reactive":[104],"protein,":[105],"IL-6":[106],"tumor":[108],"necrosis":[109],"factor-alpha":[110],"measured":[112],"ELISA.":[114],"RESULTS:":[115],"increased":[120],"did":[127],"not":[128],"differ":[129],"between":[130],"volunteers.":[135],"patient":[146],"group.":[147],"CONCLUSIONS:":[148],"Chronic":[149],"inflammation":[150],"could":[151],"be":[152],"responsible":[153],"for":[154],"zeta-":[158],"chain":[159],"downregulation":[160],"patients,":[163],"contributing":[164],"activity.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}