{"id":"https://openalex.org/W2005104217","doi":"https://doi.org/10.1002/ijc.24482","title":"Anti\u2010endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature","display_name":"Anti\u2010endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature","publication_year":2009,"publication_date":"2009-04-06","ids":{"openalex":"https://openalex.org/W2005104217","doi":"https://doi.org/10.1002/ijc.24482","mag":"2005104217","pmid":"https://pubmed.ncbi.nlm.nih.gov/19533687","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367950"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.24482","doi":"https://doi.org/10.1002/ijc.24482","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.24482","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367950","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049934692","display_name":"Shima Uneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shima Uneda","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079997687","display_name":"Hirofumi Toi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hirofumi Toi","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024384664","display_name":"Tomoko Tsujie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoko Tsujie","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079989633","display_name":"Masanori Tsujie","orcid":"https://orcid.org/0000-0002-1265-3397","observed_orcids":["https://orcid.org/0000-0002-1265-3397"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Tsujie","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109095907","display_name":"Naoko Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoko Harada","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072265729","display_name":"Hilda Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilda Tsai","raw_affiliation_strings":["Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111447148","display_name":"Ben K. Seon","orcid":"https://orcid.org/0009-0003-8765-679X","observed_orcids":["https://orcid.org/0009-0003-8765-679X"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ben K. Seon","raw_affiliation_strings":["","Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. USA","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111447148"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.0876,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.86684235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"125","issue":"6","first_page":"1446","last_page":"1453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoglin","display_name":"CD105","score":0.9300000071525574},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.8619999885559082},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.8270000219345093},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9010000228881836},{"id":"https://openalex.org/keywords/4t1-mammary-carcinoma","display_name":"4T1 mammary carcinoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7578921914100647},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6867441534996033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6272035837173462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5756155252456665},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5445573329925537},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.5138840675354004},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.49214690923690796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4839513599872589},{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.48102885484695435},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4712657928466797},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.44952526688575745},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4369889795780182},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.390977144241333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24230611324310303},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.23066630959510803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2105739414691925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18281885981559753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071063","descriptor_name":"Endoglin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.24482","doi":"https://doi.org/10.1002/ijc.24482","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.24482","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:19533687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19533687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4367950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4367950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1663496006","display_name":null,"funder_award_id":"CA 016156","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W199065211","https://openalex.org/W317578465","https://openalex.org/W1484123114","https://openalex.org/W1568363145","https://openalex.org/W1577518201","https://openalex.org/W1590052782","https://openalex.org/W1720858567","https://openalex.org/W1973492876","https://openalex.org/W1974932725","https://openalex.org/W1975522586","https://openalex.org/W1978139448","https://openalex.org/W1987125650","https://openalex.org/W1989288638","https://openalex.org/W1990810351","https://openalex.org/W2000688337","https://openalex.org/W2002931314","https://openalex.org/W2008607938","https://openalex.org/W2013958991","https://openalex.org/W2018787215","https://openalex.org/W2022233074","https://openalex.org/W2030662016","https://openalex.org/W2034540471","https://openalex.org/W2036564049","https://openalex.org/W2038814413","https://openalex.org/W2040830176","https://openalex.org/W2042883628","https://openalex.org/W2065947474","https://openalex.org/W2066905497","https://openalex.org/W2068547096","https://openalex.org/W2070291618","https://openalex.org/W2070446470","https://openalex.org/W2072075258","https://openalex.org/W2073071344","https://openalex.org/W2073079990","https://openalex.org/W2083437069","https://openalex.org/W2084579153","https://openalex.org/W2093921289","https://openalex.org/W2094769459","https://openalex.org/W2114764382","https://openalex.org/W2122846135","https://openalex.org/W2128005193","https://openalex.org/W2130250397","https://openalex.org/W2135924006","https://openalex.org/W2152574565","https://openalex.org/W2153125007","https://openalex.org/W2157154128","https://openalex.org/W2157936766","https://openalex.org/W2163319080","https://openalex.org/W2169544817","https://openalex.org/W2413648231","https://openalex.org/W4234303242"],"related_works":["https://openalex.org/W2030349987","https://openalex.org/W2114764382","https://openalex.org/W2070446470","https://openalex.org/W1989288638","https://openalex.org/W2130250397","https://openalex.org/W1990810351","https://openalex.org/W2034540471","https://openalex.org/W2163319080","https://openalex.org/W2395240469","https://openalex.org/W2252896286"],"abstract_inverted_index":{"Anti-metastatic":[0],"activity":[1],"of":[2,15,43,45,50,75,84,87,102,111,114,121,138,170,182,202,215,220,225],"an":[3],"antitumor":[4],"agent":[5],"is":[6,11],"exceedingly":[7],"important":[8],"because":[9],"metastasis":[10,57,60,201],"the":[12,55,99,109,117,122,135,141,160,171,183,207,216],"primary":[13,136],"cause":[14],"death":[16],"for":[17,133,198],"most":[18],"solid":[19],"cancer":[20],"patients.":[21],"In":[22,127],"this":[23],"report,":[24],"we":[25],"show":[26],"that":[27],"3":[28],"anti-endoglin":[29],"(ENG)":[30],"monoclonal":[31],"antibodies":[32],"(mAbs)":[33],"SN6a,":[34],"SN6j":[35,106,179],"and":[36,81,105,143,153,178,188],"SN6k":[37,187],"which":[38],"define":[39],"individually":[40],"distinct":[41],"epitopes":[42],"ENG":[44],"tumor":[46,52],"vasculature":[47],"are":[48,210],"capable":[49],"suppressing":[51,134,199],"metastases":[53],"in":[54,116,119,140,155,164,206,213],"multiple":[56],"models.":[58,126],"The":[59,204],"models":[61],"were":[62,95,131,174,195],"generated":[63],"by":[64,159],"i.v.,":[65],"s.c.":[66],"(into":[67],"flank)":[68],"or":[69],"mammary":[70,78,144],"gland":[71],"fat":[72,145],"pad":[73],"injection":[74,83],"4T1":[76,115,124,139],"murine":[77,89],"carcinoma":[79,91],"cells":[80],"splenic":[82],"two":[85],"types":[86],"colon26":[88],"colorectal":[90],"cells.":[92],"Individual":[93],"mAbs":[94,130,148,173],"injected":[96],"i.v.":[97],"via":[98],"tail":[100],"vein":[101],"mice.":[103,165,185],"SN6a":[104,177],"effectively":[107,149],"suppressed":[108,150],"formation":[110],"metastatic":[112,125],"colonies":[113],"lung":[118],"all":[120,196],"three":[123],"addition,":[128],"these":[129],"effective":[132,197],"tumors":[137,156],"skin":[142],"pad.":[146],"These":[147],"microvessel":[151],"density":[152],"angiogenesis":[154],"as":[157],"measured":[158],"Matrigel":[161],"plug":[162],"assay":[163],"No":[166],"significant":[167],"side":[168],"effects":[169],"administered":[172],"detected.":[175],"Furthermore,":[176],"extended":[180],"survival":[181],"tumor-bearing":[184],"SN6j,":[186],"their":[189],"immunoconjugates":[190],"with":[191],"deglycosylated":[192],"ricin":[193],"A-chain":[194],"hepatic":[200],"colon26.":[203],"findings":[205],"present":[208],"study":[209],"clinically":[211],"relevant":[212],"view":[214],"ongoing":[217],"clinical":[218],"trial":[219],"a":[221],"humanized":[222],"(chimerized)":[223],"form":[224],"SN6j.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
