{"id":"https://openalex.org/W2005000591","doi":"https://doi.org/10.1016/j.tetlet.2008.06.067","title":"Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling","display_name":"Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling","publication_year":2008,"publication_date":"2008-06-21","ids":{"openalex":"https://openalex.org/W2005000591","doi":"https://doi.org/10.1016/j.tetlet.2008.06.067","mag":"2005000591"},"language":"en","primary_location":{"id":"doi:10.1016/j.tetlet.2008.06.067","doi":"https://doi.org/10.1016/j.tetlet.2008.06.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2008.06.067","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.tetlet.2008.06.067","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112559151","display_name":"Mark J. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark J. Thompson","raw_affiliation_strings":["Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK","Department of Chemistry University of Sheffield Brook Hill Sheffield S3 7HF UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Chemistry University of Sheffield Brook Hill Sheffield S3 7HF UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020099630","display_name":"Beining Chen","orcid":"https://orcid.org/0000-0003-4771-218X","observed_orcids":["https://orcid.org/0000-0003-4771-218X"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Beining Chen","raw_affiliation_strings":["Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK","Department of Chemistry University of Sheffield Brook Hill Sheffield S3 7HF UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Chemistry University of Sheffield Brook Hill Sheffield S3 7HF UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020099630"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.9916,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.71862295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"49","issue":"36","first_page":"5324","last_page":"5327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13304","display_name":"Synthesis and Reactivity of Sulfur-Containing Compounds","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ugi-reaction","display_name":"Ugi reaction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lawesson-s-reagent","display_name":"Lawesson's reagent","score":0.9350000023841858},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/multicomponent-reactions","display_name":"multicomponent reactions","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9698335528373718},{"id":"https://openalex.org/C2777010268","wikidata":"https://www.wikidata.org/wiki/Q421897","display_name":"Isocyanide","level":2,"score":0.9445706009864807},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.8775250911712646},{"id":"https://openalex.org/C2779070456","wikidata":"https://www.wikidata.org/wiki/Q2002373","display_name":"Ugi reaction","level":3,"score":0.8312976956367493},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.7676668763160706},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.6982523202896118},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.6013116836547852},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5867624282836914},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5674527883529663},{"id":"https://openalex.org/C2778464347","wikidata":"https://www.wikidata.org/wiki/Q413426","display_name":"Thiazole","level":2,"score":0.45390546321868896},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3600771427154541},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3421257734298706},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.tetlet.2008.06.067","doi":"https://doi.org/10.1016/j.tetlet.2008.06.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2008.06.067","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.tetlet.2008.06.067","doi":"https://doi.org/10.1016/j.tetlet.2008.06.067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2008.06.067","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1756790272","display_name":null,"funder_award_id":"BB/E014119/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1971652833","https://openalex.org/W1975816659","https://openalex.org/W1995925505","https://openalex.org/W2012002347","https://openalex.org/W2014764726","https://openalex.org/W2019845694","https://openalex.org/W2028632105","https://openalex.org/W2046349840","https://openalex.org/W2067232766","https://openalex.org/W2069764649","https://openalex.org/W2099985251","https://openalex.org/W2100821181","https://openalex.org/W2111677437","https://openalex.org/W2145643470","https://openalex.org/W2158584812","https://openalex.org/W2161332424","https://openalex.org/W2168968864","https://openalex.org/W2176572634","https://openalex.org/W2949533601","https://openalex.org/W2949850785","https://openalex.org/W2952673290"],"related_works":["https://openalex.org/W1997262440","https://openalex.org/W2896661810","https://openalex.org/W2952767612","https://openalex.org/W4319764625","https://openalex.org/W2036357104","https://openalex.org/W2334777895","https://openalex.org/W2950488914","https://openalex.org/W3094951623","https://openalex.org/W2951344012","https://openalex.org/W2950522446"],"abstract_inverted_index":{"A":[0],"flexible":[1],"route":[2],"to":[3,46],"novel":[4],"5-aminothiazoles":[5],"has":[6],"been":[7],"developed":[8],"based":[9],"on":[10],"cyclisation":[11],"of":[12,24,41,56],"diamide":[13],"adducts,":[14],"prepared":[15,52],"using":[16],"the":[17,22,35,42,59],"Ugi":[18],"reaction":[19],",":[20],"in":[21],"presence":[23],"Lawesson\u2019s":[25],"reagent.":[26],"The":[27],"Walborsky":[28],"reagent":[29],"(1,1,3,3-tetramethylbutyl":[30],"isocyanide)":[31],"was":[32],"used":[33],"as":[34],"isonitrile":[36],"component,":[37],"facilitating":[38],"subsequent":[39],"deprotection":[40],"N":[43],"-alkyl":[44],"group":[45],"yield":[47],"free":[48],"5-aminothiazoles,":[49],"which":[50],"were":[51],"with":[53],"a":[54],"variety":[55],"substituents":[57],"at":[58],"2-":[60],"and":[61],"4-positions.":[62]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}