{"id":"https://openalex.org/W2004983368","doi":"https://doi.org/10.1101/sqb.1970.035.01.049","title":"The Regulation of RNA Synthesis during Growth Rate Transitions and Amino Acid Deprivation in E. coli","display_name":"The Regulation of RNA Synthesis during Growth Rate Transitions and Amino Acid Deprivation in E. coli","publication_year":1970,"publication_date":"1970-01-01","ids":{"openalex":"https://openalex.org/W2004983368","doi":"https://doi.org/10.1101/sqb.1970.035.01.049","mag":"2004983368"},"language":"en","primary_location":{"id":"doi:10.1101/sqb.1970.035.01.049","doi":"https://doi.org/10.1101/sqb.1970.035.01.049","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.1970.035.01.049","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084958891","display_name":"Robert A. Lazzarini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I35344726","display_name":"United States Public Health Service","ror":"https://ror.org/05xf94514","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I35344726"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. Lazzarini","raw_affiliation_strings":["Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public\n                           Health Service, U.S. Department of Health, Educational, and Welfare, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public\n                           Health Service, U.S. Department of Health, Educational, and Welfare, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I35344726","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111487726","display_name":"R. M. Winslow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I35344726","display_name":"United States Public Health Service","ror":"https://ror.org/05xf94514","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I35344726"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Winslow","raw_affiliation_strings":["Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public\n                           Health Service, U.S. Department of Health, Educational, and Welfare, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public\n                           Health Service, U.S. Department of Health, Educational, and Welfare, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I35344726","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"0","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.2587999999523163,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-synthesis-regulation","display_name":"RNA synthesis regulation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rrna-synthesis","display_name":"ribosomal RNA synthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8830000162124634},{"id":"https://openalex.org/keywords/amino-acid-starvation","display_name":"amino acid starvation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-composition","display_name":"cell composition","score":0.6840000152587891},{"id":"https://openalex.org/keywords/protein-synthesis-rate","display_name":"protein synthesis rate","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ribosome-content","display_name":"ribosome content","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.822689950466156},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.7486366629600525},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7270704507827759},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.7112898826599121},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.5865387916564941},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5621722936630249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48921704292297363},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.47936326265335083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46340346336364746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4602905511856079},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44812318682670593},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43115025758743286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4292055368423462},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.4202345311641693},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4150159955024719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21166783571243286},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/sqb.1970.035.01.049","doi":"https://doi.org/10.1101/sqb.1970.035.01.049","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.1970.035.01.049","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W195761934","https://openalex.org/W2077943758","https://openalex.org/W2074151919","https://openalex.org/W1979218152","https://openalex.org/W2080103332","https://openalex.org/W43588197","https://openalex.org/W1527840442","https://openalex.org/W1987573108","https://openalex.org/W2114746743","https://openalex.org/W2065247096"],"abstract_inverted_index":{"The":[0],"composition":[1,16,57],"of":[2,13,17,40,50,66,80,94],"bacterial":[3],"cells":[4,43],"shows":[5],"a":[6,47],"regular":[7],"variation":[8],"with":[9,74,101],"growth":[10,59,75],"rate,":[11],"irrespective":[12],"the":[14,18,55,63,81,92,102],"chemical":[15],"medium":[19],"(Schaechter,":[20,83],"Maal\u00f8e,":[21,84],"and":[22,26,58,85],"Kjeldgaard,":[23,86],"1958;":[24],"Neidhardt":[25],"Magasanik,":[27],"1960).":[28],"Cells":[29],"cultured":[30],"in":[31],"rich":[32],"media":[33,45],"contain":[34],"more":[35],"RNA":[36,96],"per":[37,69],"genome":[38],"equivalent":[39],"DNA":[41],"than":[42],"from":[44],"supporting":[46],"slow":[48],"rate":[49,60,65,76],"growth.":[51],"Calculations":[52],"based":[53],"on":[54],"cell":[56,82],"indicate":[61,90],"that":[62,91],"average":[64],"protein":[67,106],"synthesis":[68,93],"ribosome":[70,78],"does":[71],"not":[72],"vary":[73],"or":[77],"content":[79],"1958).":[87],"These":[88],"results":[89],"ribosomal":[95],"(rRNA)":[97],"is":[98],"well":[99],"coordinated":[100],"cell's":[103],"capacity":[104],"for":[105],"synthesis.":[107]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
