{"id":"https://openalex.org/W2004967282","doi":"https://doi.org/10.1001/archpsyc.1995.03950220056011","title":"Suicidal Behaviors and the Tryptophan Hydroxylase Gene","display_name":"Suicidal Behaviors and the Tryptophan Hydroxylase Gene","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2004967282","doi":"https://doi.org/10.1001/archpsyc.1995.03950220056011","mag":"2004967282","pmid":"https://pubmed.ncbi.nlm.nih.gov/7575104"},"language":"en","primary_location":{"id":"doi:10.1001/archpsyc.1995.03950220056011","doi":"https://doi.org/10.1001/archpsyc.1995.03950220056011","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1995.03950220056011","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044681586","display_name":"Mocrane Abbar","orcid":"https://orcid.org/0000-0001-7394-0368","observed_orcids":["https://orcid.org/0000-0001-7394-0368"]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mocrane Abbar","raw_affiliation_strings":["Department of Psychiatry, University of Montpellier-Nimes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Montpellier-Nimes, France","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044681586"],"corresponding_institution_ids":["https://openalex.org/I19894307"],"apc_list":null,"apc_paid":null,"fwci":6.4223,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96700369,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"10","first_page":"846","last_page":"846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suicidal-behavior","display_name":"suicidal behavior","score":0.9020000100135803},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.7960000038146973},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6949999928474426},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.9063521027565002},{"id":"https://openalex.org/C2780468923","wikidata":"https://www.wikidata.org/wiki/Q7431050","display_name":"Schedule for Affective Disorders and Schizophrenia","level":3,"score":0.6003576517105103},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.47005972266197205},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.46832945942878723},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.4574621617794037},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.452933132648468},{"id":"https://openalex.org/C2780842732","wikidata":"https://www.wikidata.org/wiki/Q3518184","display_name":"Suicide attempt","level":4,"score":0.44272661209106445},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.4305777847766876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4066758155822754},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3795578181743622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35830241441726685},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3495739698410034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3464866578578949},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.34183889627456665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32517850399017334},{"id":"https://openalex.org/C526869908","wikidata":"https://www.wikidata.org/wiki/Q3298118","display_name":"Suicide prevention","level":3,"score":0.2961958348751068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19053450226783752},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.09280943870544434},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.0770343542098999},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archpsyc.1995.03950220056011","doi":"https://doi.org/10.1001/archpsyc.1995.03950220056011","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1995.03950220056011","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},{"id":"pmid:7575104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7575104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of general psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1591987091","https://openalex.org/W1596146531","https://openalex.org/W1996741935","https://openalex.org/W1997734783","https://openalex.org/W2000277154","https://openalex.org/W2006851386","https://openalex.org/W2011388046","https://openalex.org/W2030272341","https://openalex.org/W2036362108","https://openalex.org/W2039230966","https://openalex.org/W2042328265","https://openalex.org/W2044599947","https://openalex.org/W2079419868","https://openalex.org/W2090078679","https://openalex.org/W2094445259","https://openalex.org/W2094700723","https://openalex.org/W2097149857","https://openalex.org/W2098978408","https://openalex.org/W2114766874","https://openalex.org/W2123466824","https://openalex.org/W2128108357","https://openalex.org/W2152121587","https://openalex.org/W2248992431","https://openalex.org/W2252813415","https://openalex.org/W2336242231","https://openalex.org/W3143934900"],"related_works":["https://openalex.org/W1969470528","https://openalex.org/W88791355","https://openalex.org/W2072353490","https://openalex.org/W1965527434","https://openalex.org/W2406289230","https://openalex.org/W2410025091","https://openalex.org/W1972704616","https://openalex.org/W1976766430","https://openalex.org/W1599173510","https://openalex.org/W2005633507"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"determine":[2],"whether":[3],"the":[4,9,14,18,46,49,70,81,122],"tryptophan":[5,52,101,110],"hydroxylase":[6,53,102,111],"gene":[7,10,112],"(ie,":[8],"that":[11],"codes":[12],"for":[13,28,72,80,118],"rate-limiting":[15],"enzyme":[16],"in":[17,56,93,121,127],"metabolic":[19],"pathway":[20],"of":[21,48,63,83,124],"serotonin)":[22],"may":[23],"be":[24],"a":[25,37,115],"susceptibility":[26,116],"factor":[27,117],"suicidal":[29,104,119],"behavior.":[30],"METHODS:":[31],"Genotypic":[32],"and":[33,75,86,103],"allelic":[34],"frequencies":[35],"at":[36],"polymorphic":[38],"Ava":[39],"II":[40],"restriction":[41],"site":[42],"were":[43,67,89],"revealed":[44],"with":[45,78,91],"use":[47],"complementary":[50],"DNA":[51],"probe":[54],"C2-38":[55],"62":[57],"suicide":[58,65,125],"attempters.":[59],"The":[60,109],"psychiatric":[61],"characteristics":[62,88],"these":[64,87],"attempters":[66,126],"determined":[68],"using":[69],"Schedule":[71],"Affective":[73],"Disorders":[74],"Schizophrenia-Lifetime":[76],"version":[77],"modification":[79],"study":[82],"anxiety":[84],"disorders,":[85],"compared":[90],"those":[92],"52":[94],"healthy":[95],"controls.":[96],"RESULTS:":[97],"No":[98],"association":[99],"between":[100],"behavior":[105],"was":[106,113],"detected.":[107],"CONCLUSION:":[108],"not":[114],"behaviors":[120],"group":[123],"this":[128],"study.":[129]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}