{"id":"https://openalex.org/W2004942012","doi":"https://doi.org/10.1016/j.nbd.2015.03.022","title":"VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes","display_name":"VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes","publication_year":2015,"publication_date":"2015-04-05","ids":{"openalex":"https://openalex.org/W2004942012","doi":"https://doi.org/10.1016/j.nbd.2015.03.022","mag":"2004942012","pmid":"https://pubmed.ncbi.nlm.nih.gov/25829228"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2015.03.022","doi":"https://doi.org/10.1016/j.nbd.2015.03.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nbd.2015.03.022","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/c0bda7177aa0407d89fa63f33b03e90c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053391152","display_name":"Stephanie L. Taylor","orcid":"https://orcid.org/0000-0002-4813-4257","observed_orcids":["https://orcid.org/0000-0002-4813-4257"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephanie L. Taylor","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084111120","display_name":"Dustin Trudeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dustin Trudeau","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046142950","display_name":"Brendan John Arnold","orcid":"https://orcid.org/0009-0000-4653-8998","observed_orcids":["https://orcid.org/0009-0000-4653-8998"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brendan Arnold","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017854682","display_name":"Joshua Wang","orcid":"https://orcid.org/0000-0002-3490-6957","observed_orcids":["https://orcid.org/0000-0002-3490-6957"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joshua Wang","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006358163","display_name":"Kim Gerrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kim Gerrow","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052718090","display_name":"Kieran Summerfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kieran Summerfeldt","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109394309","display_name":"Andrew S. Holmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Holmes","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064106401","display_name":"Akram Zamani","orcid":"https://orcid.org/0000-0003-0899-1227","observed_orcids":["https://orcid.org/0000-0003-0899-1227"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Akram Zamani","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001412483","display_name":"Patr\u00edcia S. Brocardo","orcid":"https://orcid.org/0000-0002-1680-5909","observed_orcids":["https://orcid.org/0000-0002-1680-5909"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patricia S. Brocardo","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada"],"raw_orcid":"https://orcid.org/0000-0002-1680-5909","affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Division of Medical Sciences University of Victoria Victoria BC V8P 5C2 Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031236885","display_name":"Craig E. Brown","orcid":"https://orcid.org/0000-0002-0076-2414","observed_orcids":["https://orcid.org/0000-0002-0076-2414"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Craig E. Brown","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada; Department of Biology, University of Victoria, Victoria, BC V8P 5C2, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address: brownc@uvic.ca","Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada; Department of Biology, University of Victoria, Victoria, BC V8P 5C2, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address: brownc@uvic.ca","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I212119943"]},{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031236885"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I212119943"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":1.6916,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.82474742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"78","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.23029999434947968,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/blood-brain-barrier-dysfunction","display_name":"blood-brain barrier dysfunction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dendritic-spine-loss","display_name":"dendritic spine loss","score":0.8389999866485596},{"id":"https://openalex.org/keywords/spatial-memory-impairment","display_name":"spatial memory impairment","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.628000020980835},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.656000018119812},{"id":"https://openalex.org/keywords/diabetic-vascular-disease","display_name":"diabetic vascular disease","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6869644522666931},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.6710526347160339},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6419229507446289},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6256375908851624},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6226450800895691},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.602628767490387},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5640403032302856},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.5394800901412964},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.5210037231445312},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4952014982700348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48106837272644043},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40642455220222473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.405879408121109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3924705386161804},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1882166862487793},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.17555299401283264}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065852","descriptor_name":"Spatial Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065852","descriptor_name":"Spatial Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065852","descriptor_name":"Spatial Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.nbd.2015.03.022","doi":"https://doi.org/10.1016/j.nbd.2015.03.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nbd.2015.03.022","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"pmid:25829228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25829228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c0bda7177aa0407d89fa63f33b03e90c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c0bda7177aa0407d89fa63f33b03e90c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 78, Iss , Pp 1-11 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:c0bda7177aa0407d89fa63f33b03e90c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c0bda7177aa0407d89fa63f33b03e90c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 78, Iss , Pp 1-11 (2015)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7021617524","display_name":null,"funder_award_id":"RGPIN 371-931-2009","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G9000024508","display_name":null,"funder_award_id":"MOP 102470","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320307845","display_name":"Heart and Stroke Foundation of Canada","ror":"https://ror.org/00qbpyp73"},{"id":"https://openalex.org/F4320314621","display_name":"Heart and Stroke Foundation of British Columbia and Yukon","ror":"https://ror.org/05r6zdt74"},{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1744280301","https://openalex.org/W1965354923","https://openalex.org/W1969024031","https://openalex.org/W1972448300","https://openalex.org/W1974790096","https://openalex.org/W1976313368","https://openalex.org/W1976398449","https://openalex.org/W1978614509","https://openalex.org/W1984551681","https://openalex.org/W1984797021","https://openalex.org/W1987278634","https://openalex.org/W1987522740","https://openalex.org/W1992112653","https://openalex.org/W1992758695","https://openalex.org/W2008125614","https://openalex.org/W2008523702","https://openalex.org/W2016261700","https://openalex.org/W2017169966","https://openalex.org/W2021612766","https://openalex.org/W2030265072","https://openalex.org/W2030697228","https://openalex.org/W2031635410","https://openalex.org/W2034285129","https://openalex.org/W2034292395","https://openalex.org/W2035107871","https://openalex.org/W2037504726","https://openalex.org/W2042222492","https://openalex.org/W2042894225","https://openalex.org/W2045251148","https://openalex.org/W2048101178","https://openalex.org/W2048288736","https://openalex.org/W2050749363","https://openalex.org/W2053068006","https://openalex.org/W2055385369","https://openalex.org/W2056456156","https://openalex.org/W2057920967","https://openalex.org/W2060167275","https://openalex.org/W2063440740","https://openalex.org/W2064982871","https://openalex.org/W2069649629","https://openalex.org/W2074883197","https://openalex.org/W2076752309","https://openalex.org/W2076962138","https://openalex.org/W2081877609","https://openalex.org/W2082853248","https://openalex.org/W2083227916","https://openalex.org/W2083900005","https://openalex.org/W2084484659","https://openalex.org/W2084498863","https://openalex.org/W2086062010","https://openalex.org/W2089852381","https://openalex.org/W2102166270","https://openalex.org/W2105676498","https://openalex.org/W2106527155","https://openalex.org/W2112256576","https://openalex.org/W2118463227","https://openalex.org/W2120447295","https://openalex.org/W2121567769","https://openalex.org/W2121890486","https://openalex.org/W2123007201","https://openalex.org/W2126897836","https://openalex.org/W2127632053","https://openalex.org/W2127810309","https://openalex.org/W2128550469","https://openalex.org/W2128894005","https://openalex.org/W2130626955","https://openalex.org/W2135231776","https://openalex.org/W2136800398","https://openalex.org/W2142151422","https://openalex.org/W2143167585","https://openalex.org/W2143605092","https://openalex.org/W2146310895","https://openalex.org/W2147461659","https://openalex.org/W2157119004","https://openalex.org/W2158078597","https://openalex.org/W2159003130","https://openalex.org/W2162539167","https://openalex.org/W2171715330","https://openalex.org/W2171845476"],"related_works":["https://openalex.org/W2081592958","https://openalex.org/W2360575762","https://openalex.org/W344178925","https://openalex.org/W1952455747","https://openalex.org/W2724124861","https://openalex.org/W3004744970","https://openalex.org/W4236068981","https://openalex.org/W2189448773","https://openalex.org/W2553037035","https://openalex.org/W2522700401"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
