{"id":"https://openalex.org/W2004887075","doi":"https://doi.org/10.1128/mcb.05442-11","title":"Human GTPases Associate with RNA Polymerase II To Mediate Its Nuclear Import","display_name":"Human GTPases Associate with RNA Polymerase II To Mediate Its Nuclear Import","publication_year":2011,"publication_date":"2011-07-18","ids":{"openalex":"https://openalex.org/W2004887075","doi":"https://doi.org/10.1128/mcb.05442-11","mag":"2004887075","pmid":"https://pubmed.ncbi.nlm.nih.gov/21768307","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3187354"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.05442-11","doi":"https://doi.org/10.1128/mcb.05442-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.05442-11","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3187354/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041164066","display_name":"Cl\u00e9ment Carr\u00e9","orcid":"https://orcid.org/0000-0002-9668-4288","observed_orcids":["https://orcid.org/0000-0002-9668-4288"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Cl\u00e9ment Carr\u00e9","raw_affiliation_strings":["Centre for Genomic Regulation, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003 Barcelona, Spain","The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104","2 Centre for Genomic Regulation, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic Regulation, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210137962"]},{"raw_affiliation_string":"The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"2 Centre for Genomic Regulation, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210137962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085435182","display_name":"Ramin Shiekhattar","orcid":"https://orcid.org/0000-0002-7943-7277","observed_orcids":["https://orcid.org/0000-0002-7943-7277"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramin Shiekhattar","raw_affiliation_strings":["The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041164066","https://openalex.org/A5085435182"],"corresponding_institution_ids":["https://openalex.org/I102322052","https://openalex.org/I170486558","https://openalex.org/I4210137962"],"apc_list":null,"apc_paid":null,"fwci":1.9259,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.858858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"31","issue":"19","first_page":"3953","last_page":"3962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rpb7","display_name":"Rpb7","score":0.5590000152587891},{"id":"https://openalex.org/keywords/rpb4","display_name":"Rpb4","score":0.8650000095367432},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dominant-negative-mutant","display_name":"dominant-negative mutant","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7435073256492615},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.729826807975769},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.7226656079292297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6666046380996704},{"id":"https://openalex.org/C160704184","wikidata":"https://www.wikidata.org/wiki/Q18031028","display_name":"Ran","level":2,"score":0.6500297784805298},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.5286256074905396},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5031449198722839},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.448652982711792},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40281715989112854},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.3898216485977173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22544395923614502},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10933011770248413},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.09778738021850586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0968027412891388},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.09565714001655579}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.05442-11","doi":"https://doi.org/10.1128/mcb.05442-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.05442-11","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:21768307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21768307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3187354","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3187354/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3187354","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3187354/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1902070349","https://openalex.org/W1963837739","https://openalex.org/W1964667809","https://openalex.org/W1972137518","https://openalex.org/W1992491954","https://openalex.org/W2000832682","https://openalex.org/W2026614899","https://openalex.org/W2037057785","https://openalex.org/W2047532612","https://openalex.org/W2050207858","https://openalex.org/W2059691911","https://openalex.org/W2065942523","https://openalex.org/W2077167882","https://openalex.org/W2092558918","https://openalex.org/W2102136488","https://openalex.org/W2114040881","https://openalex.org/W2118526138","https://openalex.org/W2120088072","https://openalex.org/W2126503680","https://openalex.org/W2134304018","https://openalex.org/W2136424731","https://openalex.org/W2141135583","https://openalex.org/W2142437744","https://openalex.org/W2152499201","https://openalex.org/W2152927202","https://openalex.org/W2153549621","https://openalex.org/W2786774014"],"related_works":["https://openalex.org/W2120088072","https://openalex.org/W3170872181","https://openalex.org/W2093571583","https://openalex.org/W2074431873","https://openalex.org/W2094653341","https://openalex.org/W7096409508","https://openalex.org/W2055621384","https://openalex.org/W2239022658","https://openalex.org/W2958226629","https://openalex.org/W2001001702"],"abstract_inverted_index":{"Small":[0],"GTPases":[1,17,41,144],"share":[2],"a":[3,107,115,126,139],"biochemical":[4],"mechanism":[5],"and":[6,27,38,59,68,92],"act":[7],"as":[8],"binary":[9],"molecular":[10],"switches.":[11],"One":[12],"important":[13],"function":[14],"of":[15,24,35,73,76,95,101,106,134,142,151],"small":[16,40,81,143],"in":[18,89,98,121,131],"the":[19,32,53,69,90,99,122,149,156],"cell":[20,112],"is":[21],"nucleocytoplasmic":[22],"transport":[23,150],"both":[25],"proteins":[26,130],"RNA.":[28],"Here,":[29],"we":[30],"show":[31],"stable":[33,111],"association":[34],"human":[36,102],"GPN1":[37,58,77,118],"GPN3,":[39],"related":[42],"to":[43,85],"Ran,":[44],"with":[45,63],"RNA":[46,152],"polymerase":[47,153],"II":[48,154],"(RNAPII)":[49],"isolated":[50],"from":[51,110],"either":[52],"cytoplasmic":[54],"or":[55,78],"nuclear":[56,132],"fraction.":[57],"GPN3":[60,79],"directly":[61],"interact":[62],"RNAPII":[64,87],"subunit":[65],"7":[66],"(RPB7)/RPB4":[67],"C-terminal":[70],"domain":[71],"(CTD)":[72],"RNAPII.":[74,135],"Depletion":[75],"using":[80],"interfering":[82],"RNAs":[83],"led":[84],"decreased":[86],"levels":[88],"nucleus":[91],"an":[93],"accumulation":[94],"this":[96],"enzyme":[97],"cytoplasm":[100],"cells.":[103],"Furthermore,":[104],"isolation":[105],"GPN1/GPN3/RNAPII":[108],"complex":[109],"lines":[113],"expressing":[114],"dominant":[116],"negative":[117],"harboring":[119],"mutations":[120],"GTP-binding":[123],"pocket":[124],"demonstrated":[125],"role":[127],"for":[128,148],"these":[129],"import":[133],"Thus,":[136],"GPN1/GPN3":[137],"define":[138],"new":[140],"family":[141],"that":[145],"are":[146],"specialized":[147],"into":[155],"nucleus.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
