{"id":"https://openalex.org/W200487902","doi":null,"title":"Sulphate-bicarbonate mineral waters in the treatment of biliary and digestive tract diseases.","display_name":"Sulphate-bicarbonate mineral waters in the treatment of biliary and digestive tract diseases.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W200487902","mag":"200487902","pmid":"https://pubmed.ncbi.nlm.nih.gov/20499033"},"language":"en","primary_location":{"id":"pmid:20499033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20499033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086949920","display_name":"A Fraioli","orcid":"https://orcid.org/0000-0003-0366-7081","observed_orcids":["https://orcid.org/0000-0003-0366-7081"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Fraioli","raw_affiliation_strings":["Operative Unit of Internal Medicine E, Medical Therapy and Thermal Medicine, Postgraduate School in Medical Hydrology, Department Medical Clinics and Therapy, Sapienza University of Rome, Italy. antonio.fraioli@uniroma1.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Operative Unit of Internal Medicine E, Medical Therapy and Thermal Medicine, Postgraduate School in Medical Hydrology, Department Medical Clinics and Therapy, Sapienza University of Rome, Italy. antonio.fraioli@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144625267","display_name":"Gioacchino MENNUNI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Menunni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060383949","display_name":"Luisa Petraccia","orcid":"https://orcid.org/0000-0001-7171-3428","observed_orcids":["https://orcid.org/0000-0001-7171-3428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Petraccia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009117073","display_name":"Mario Fontana","orcid":"https://orcid.org/0000-0002-7524-3395","observed_orcids":["https://orcid.org/0000-0002-7524-3395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fontana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088390230","display_name":"S Nocchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nocchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102919118","display_name":"M Grassi","orcid":"https://orcid.org/0009-0008-8904-4988","observed_orcids":["https://orcid.org/0009-0008-8904-4988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Grassi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.878,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.88289963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"161","issue":"2","first_page":"163","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13108","display_name":"Therapeutic Uses of Natural Elements","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13108","display_name":"Therapeutic Uses of Natural Elements","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/balneotherapy","display_name":"balneotherapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/biliary-tract-diseases","display_name":"biliary tract diseases","score":0.8040000200271606},{"id":"https://openalex.org/keywords/gallstones","display_name":"gallstones","score":0.625},{"id":"https://openalex.org/keywords/biliary-dyskinesia","display_name":"biliary dyskinesia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/functional-dyspepsia","display_name":"functional dyspepsia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chronic-constipation","display_name":"chronic constipation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/magnesium-sulfate","display_name":"magnesium sulfate","score":0.5690000057220459},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8183213472366333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5946455001831055},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5842776298522949},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.4739794135093689},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.45230036973953247},{"id":"https://openalex.org/C2775916161","wikidata":"https://www.wikidata.org/wiki/Q178921","display_name":"Mineral water","level":2,"score":0.4450574815273285},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3965302109718323},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001452","descriptor_name":"Balneology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001660","descriptor_name":"Biliary Tract Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008900","descriptor_name":"Mineral Waters","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:20499033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20499033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1161234","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/1161234","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/226652","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/226652","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W61263224","https://openalex.org/W1490939746","https://openalex.org/W1530767696","https://openalex.org/W1565875519","https://openalex.org/W1580903156","https://openalex.org/W1606920119","https://openalex.org/W1755786945","https://openalex.org/W1768851900","https://openalex.org/W1966133025","https://openalex.org/W1975266081","https://openalex.org/W1976419257","https://openalex.org/W2002174356","https://openalex.org/W2006735857","https://openalex.org/W2010290033","https://openalex.org/W2036679697","https://openalex.org/W2063254666","https://openalex.org/W2064201279","https://openalex.org/W2068082311","https://openalex.org/W2068272641","https://openalex.org/W2094432191","https://openalex.org/W2127582548","https://openalex.org/W2152882770","https://openalex.org/W2159752479","https://openalex.org/W2182945995","https://openalex.org/W2283456389","https://openalex.org/W2411887218","https://openalex.org/W2416295527","https://openalex.org/W2419479771","https://openalex.org/W2419549274","https://openalex.org/W2432620006","https://openalex.org/W2439901067","https://openalex.org/W2460921805","https://openalex.org/W2465368133","https://openalex.org/W2467567099","https://openalex.org/W4250685527"],"related_works":["https://openalex.org/W2418470266","https://openalex.org/W2607113415","https://openalex.org/W2414145281","https://openalex.org/W2400677090","https://openalex.org/W2400829025","https://openalex.org/W2038578103","https://openalex.org/W7000080196","https://openalex.org/W2472218007","https://openalex.org/W6925123882","https://openalex.org/W4412202980"],"abstract_inverted_index":{"The":[0,44],"authors":[1],"point":[2],"out":[3],"the":[4,13,21,55,60,102,109,143,150,163,167,170,197],"therapeutic":[5,172,198],"properties":[6],"of":[7,16,18,24,46,59,74,79,83,104,111,145,156,174,179,200],"sulphate-bicarbonate":[8,105,146,164,201],"mineral":[9,19,106,147,165,202],"waters.":[10],"After":[11],"summarizing":[12],"general":[14,75],"mechanism":[15],"action":[17],"waters,":[20,166],"main":[22],"indications":[23],"such":[25],"waters":[26,90,107,148],"in":[27,54,108,125,149,206],"thermal":[28],"treatment":[29],"are":[30,51],"examined":[31],"including:":[32],"biliary":[33,35,47,112],"sand,":[34],"dyskinesia,":[36],"functional":[37,207],"dyspepsia,":[38,208],"irritable":[39,213],"colon,":[40],"chronic":[41,209],"primitive":[42,210],"constipation.":[43],"dysfunctions":[45],"and":[48,81,94,117,129,132,159,177,212],"digestive":[49],"tracts":[50],"growing,":[52],"mainly":[53],"affluent":[56],"world,":[57],"because":[58,155],"increase":[61],"for":[62],"stress,":[63],"dietary":[64],"habits,":[65],"modern":[66],"life":[67],"style.":[68],"Now":[69],"they":[70,141],"affect":[71],"from":[72],"2,4%":[73],"population":[76],"to":[77,86],"7%":[78],"men":[80],"20%":[82],"women,":[84],"according":[85],"different":[87],"studies.":[88],"Mineral":[89],"can":[91],"improve":[92],"symptoms":[93],"care":[95],"some":[96],"physiopathological":[97],"underlying":[98],"mechanisms.":[99],"Authors":[100,168],"stress":[101],"efficacy":[103],"therapy":[110],"dyskinesias,":[113],"namely":[114],"gallbladder":[115],"hypokinesia":[116],"Oddi's":[118],"sphincter":[119],"spasm,":[120],"caused":[121],"by":[122,192],"their":[123,157],"content":[124],"SO4":[126],"=":[127],"anion":[128],"Mg++":[130],"cation":[131],"related":[133],"effects":[134,144],"on":[135,187],"paracrine-endocrine":[136],"gastrointestinal":[137],"system.":[138],"In":[139],"addition,":[140],"report":[142],"lithogenic":[151],"bile":[152],"(sand":[153],"bile),":[154],"diluting":[158],"washing":[160],"activity.":[161],"Among":[162],"outline":[169],"well-documented":[171],"activity":[173],"Acqua":[175,182],"Santa":[176,183],"Fucoli":[178],"Chianciano":[180],"Terme.":[181],"has":[184],"stimulating":[185],"effect":[186],"cholecystis's":[188],"motility,":[189],"as":[190],"proved":[191],"controlled":[193],"clinical":[194],"trials.":[195],"Finally,":[196],"use":[199],"water":[203],"is":[204],"discussed":[205],"constipation":[211],"bowel":[214],"syndrome.":[215]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}