{"id":"https://openalex.org/W2004855985","doi":"https://doi.org/10.1371/journal.pone.0011504","title":"A Genome-Wide Association Study of Neuroticism in a Population-Based Sample","display_name":"A Genome-Wide Association Study of Neuroticism in a Population-Based Sample","publication_year":2010,"publication_date":"2010-07-09","ids":{"openalex":"https://openalex.org/W2004855985","doi":"https://doi.org/10.1371/journal.pone.0011504","mag":"2004855985","pmid":"https://pubmed.ncbi.nlm.nih.gov/20634892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901337"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0011504","doi":"https://doi.org/10.1371/journal.pone.0011504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011504","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011504&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011504&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008185741","display_name":"Federico C. F. Calboli","orcid":"https://orcid.org/0000-0003-3176-9085","observed_orcids":["https://orcid.org/0000-0003-3176-9085"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Federico C. F. Calboli","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. f.calboli@imperial.ac.uk","Department of Epidemiology & Biostatistics, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. f.calboli@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006541865","display_name":"Federica Tozzi","orcid":"https://orcid.org/0000-0002-3536-2920","observed_orcids":["https://orcid.org/0000-0002-3536-2920"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Tozzi","raw_affiliation_strings":["Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003486843","display_name":"Nicholas W. Galwey","orcid":"https://orcid.org/0000-0002-2110-3194","observed_orcids":["https://orcid.org/0000-0002-2110-3194"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas W. Galwey","raw_affiliation_strings":["Discovery Biometrics Respiratory, GlaxoSmithKline, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Biometrics Respiratory, GlaxoSmithKline, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079479859","display_name":"Athos Antoniades","orcid":"https://orcid.org/0000-0002-5789-5103","observed_orcids":["https://orcid.org/0000-0002-5789-5103"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Athos Antoniades","raw_affiliation_strings":["Department of Computer Science, University of Cyprus, Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Cyprus, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022374956","display_name":"Vincent Mooser","orcid":"https://orcid.org/0000-0002-8632-0448","observed_orcids":["https://orcid.org/0000-0002-8632-0448","https://orcid.org/0000-0003-4675-1099"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Mooser","raw_affiliation_strings":["Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Upper Merion, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Upper Merion, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037140624","display_name":"Martin Preisig","orcid":"https://orcid.org/0000-0001-5689-4259","observed_orcids":["https://orcid.org/0000-0001-5689-4259"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Preisig","raw_affiliation_strings":["Department of Psychiatry, University Hospital Center and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University Hospital Center and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108167377","display_name":"P\u00e9ter Vollenweider","orcid":"https://orcid.org/0000-0002-0765-896X","observed_orcids":["https://orcid.org/0000-0002-0765-896X"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Vollenweider","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Center, and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Center, and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005555807","display_name":"Dawn M. Waterworth","orcid":"https://orcid.org/0000-0002-9226-1317","observed_orcids":["https://orcid.org/0000-0002-9226-1317"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Waterworth","raw_affiliation_strings":["Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Upper Merion, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Upper Merion, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047797878","display_name":"G\u00e9rard Waeber","orcid":"https://orcid.org/0000-0003-4193-788X","observed_orcids":["https://orcid.org/0000-0003-4193-788X"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gerard Waeber","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Center, and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Center, and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101943011","display_name":"Michael R. Johnson","orcid":"https://orcid.org/0000-0002-5848-9342","observed_orcids":["https://orcid.org/0000-0002-5848-9342"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael R. Johnson","raw_affiliation_strings":["Department of Clinical Neurosciences, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050995972","display_name":"Pierandrea Muglia","orcid":"https://orcid.org/0000-0002-3973-8606","observed_orcids":["https://orcid.org/0000-0002-3973-8606"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierandrea Muglia","raw_affiliation_strings":["Discovery Medicine, Neurosciences CEDD, GlaxoSmithKline R&D, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Medicine, Neurosciences CEDD, GlaxoSmithKline R&D, Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077954390","display_name":"David J. Balding","orcid":"https://orcid.org/0000-0002-1480-6115","observed_orcids":["https://orcid.org/0000-0002-1480-6115"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Balding","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom","Genetics Institute, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Genetics Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5008185741"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.0025,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.96354047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"7","first_page":"e11504","last_page":"e11504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11040","display_name":"Personality Traits and Psychology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroticism","display_name":"neuroticism","score":1.0},{"id":"https://openalex.org/keywords/personality-traits","display_name":"personality traits","score":0.9430000185966492},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.722000002861023},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gpc6","display_name":"GPC6","score":0.996999979019165},{"id":"https://openalex.org/keywords/pde4d","display_name":"PDE4D","score":0.9559999704360962},{"id":"https://openalex.org/keywords/age-interaction","display_name":"age interaction","score":0.5730000138282776},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7400000095367432},{"id":"https://openalex.org/keywords/major-effect-loci","display_name":"major-effect loci","score":0.671999990940094},{"id":"https://openalex.org/keywords/eysenck-personality-questionnaire","display_name":"Eysenck Personality Questionnaire","score":0.7990000247955322},{"id":"https://openalex.org/keywords/population-stratification","display_name":"population stratification","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C94612546","wikidata":"https://www.wikidata.org/wiki/Q1540168","display_name":"Neuroticism","level":3,"score":0.9107111692428589},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5579953789710999},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.5415217876434326},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.5005466938018799},{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.49354755878448486},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.48680540919303894},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.48212671279907227},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.47200867533683777},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4602905511856079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43615034222602844},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4321087896823883},{"id":"https://openalex.org/C2865642","wikidata":"https://www.wikidata.org/wiki/Q378132","display_name":"Big Five personality traits","level":3,"score":0.42104285955429077},{"id":"https://openalex.org/C206637850","wikidata":"https://www.wikidata.org/wiki/Q2683032","display_name":"Eysenck Personality Questionnaire","level":5,"score":0.42052289843559265},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3970990478992462},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30937427282333374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27220457792282104},{"id":"https://openalex.org/C127816348","wikidata":"https://www.wikidata.org/wiki/Q127588","display_name":"Extraversion and introversion","level":4,"score":0.1977207064628601},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19368624687194824},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.061796486377716064},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009497","descriptor_name":"Neurotic Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053673","descriptor_name":"Glypicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054684","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054703","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pone.0011504","doi":"https://doi.org/10.1371/journal.pone.0011504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011504","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011504&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2901337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20634892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20634892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/177751","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/177751","pdf_url":"https://iris.unil.ch/bitstreams/4e72ed2d-ac4e-4cd1-8286-3d62312753b1/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/52563","doi":null,"is_oa":true,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279715300015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c","pdf_url":"http://hdl.handle.net/11343/52563","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.147","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.147","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ae/b7/PLoS_One_2010_Jul_9_5(7)_e11504.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0011504","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011504","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:97239484827249bd95524d1bf1ae6559","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/97239484827249bd95524d1bf1ae6559","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 7, p e11504 (2010)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:106255","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/106255/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE , 5 (7) , Article e11504. (2010)","raw_type":"Article"},{"id":"pmh:oai:serval.unil.ch:BIB_B0C4E02333B9","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_B0C4E02333B9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos One, vol. 5, no. 7, pp. 11504","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/61414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/61414","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0011504","doi":"https://doi.org/10.1371/journal.pone.0011504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011504","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011504&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2302208292","display_name":"Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study","funder_award_id":"122661","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2957143966","display_name":null,"funder_award_id":"33CSCO","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3323220423","display_name":"Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population","funder_award_id":"118308","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3971947922","display_name":"Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey","funder_award_id":"105993","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5531419334","display_name":null,"funder_award_id":"3200B0\u2013105993","funder_id":"https://openalex.org/F4320307773","funder_display_name":"GlaxoSmithKline"},{"id":"https://openalex.org/G5599442719","display_name":null,"funder_award_id":"33CSCO-122661","funder_id":"https://openalex.org/F4320307773","funder_display_name":"GlaxoSmithKline"},{"id":"https://openalex.org/G5735209081","display_name":null,"funder_award_id":"3200B0-118308","funder_id":"https://openalex.org/F4320307773","funder_display_name":"GlaxoSmithKline"},{"id":"https://openalex.org/G6715704539","display_name":null,"funder_award_id":"3200B0","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8253295407","display_name":null,"funder_award_id":"33CSCO-122661","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320326042","display_name":"Chinese Society of Clinical Oncology","ror":"https://ror.org/05sfnze82"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004855985.pdf","grobid_xml":"https://content.openalex.org/works/W2004855985.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W60584593","https://openalex.org/W1556137194","https://openalex.org/W1734767862","https://openalex.org/W1847168837","https://openalex.org/W1965689961","https://openalex.org/W1966111889","https://openalex.org/W1967179993","https://openalex.org/W1967529528","https://openalex.org/W1977240000","https://openalex.org/W1981364522","https://openalex.org/W1981879624","https://openalex.org/W1986986810","https://openalex.org/W1990824174","https://openalex.org/W1996311338","https://openalex.org/W2010582215","https://openalex.org/W2016378819","https://openalex.org/W2019423386","https://openalex.org/W2021623374","https://openalex.org/W2022545037","https://openalex.org/W2030068504","https://openalex.org/W2034538316","https://openalex.org/W2043822013","https://openalex.org/W2047605192","https://openalex.org/W2071798324","https://openalex.org/W2072409961","https://openalex.org/W2073614305","https://openalex.org/W2079459508","https://openalex.org/W2107761897","https://openalex.org/W2108233365","https://openalex.org/W2118929411","https://openalex.org/W2123432920","https://openalex.org/W2125401121","https://openalex.org/W2129720310","https://openalex.org/W2131883242","https://openalex.org/W2134036574","https://openalex.org/W2145013003","https://openalex.org/W2146423878","https://openalex.org/W2149378411","https://openalex.org/W2149791927","https://openalex.org/W2157313769","https://openalex.org/W2157390044","https://openalex.org/W2160756148","https://openalex.org/W2161633633","https://openalex.org/W2164302084","https://openalex.org/W2164599679","https://openalex.org/W2168431596","https://openalex.org/W4235362736","https://openalex.org/W6655606893"],"related_works":["https://openalex.org/W7095771901","https://openalex.org/W1965689961","https://openalex.org/W2054609090","https://openalex.org/W2951964571","https://openalex.org/W7100721531","https://openalex.org/W1914301979","https://openalex.org/W2740637836","https://openalex.org/W2069318921","https://openalex.org/W2625502155","https://openalex.org/W2133767408"],"abstract_inverted_index":{"Neuroticism":[0,47],"is":[1],"a":[2,10,23,32,82,111,182],"moderately":[3],"heritable":[4],"personality":[5],"trait":[6],"considered":[7],"to":[8,45,140,160],"be":[9],"risk":[11],"factor":[12],"for":[13,43,122,133],"developing":[14],"major":[15,183],"depression,":[16],"anxiety":[17],"disorders":[18],"and":[19,94,117,171],"dementia.":[20],"We":[21,80,130],"performed":[22],"genome-wide":[24],"association":[25,41,107,136],"study":[26,34,42,157],"in":[27],"2,235":[28],"participants":[29],"drawn":[30],"from":[31,74],"population-based":[33],"of":[35,86,106,169,179],"neuroticism,":[36],"making":[37],"this":[38],"the":[39,51,75,177],"largest":[40],"neuroticism":[44,109],"date.":[46],"was":[48,158],"measured":[49],"by":[50],"Eysenck":[52],"Personality":[53],"Questionnaire.":[54],"After":[55],"Quality":[56],"Control,":[57],"we":[58],"analysed":[59],"430,000":[60],"autosomal":[61],"SNPs":[62,69,164],"together":[63],"with":[64,71,108,124],"an":[65],"additional":[66],"1.2":[67],"million":[68],"imputed":[70],"high":[72],"quality":[73],"Hap":[76],"Map":[77],"CEU":[78],"samples.":[79],"found":[81,131],"very":[83],"small":[84],"effect":[85,113,184],"population":[87],"stratification,":[88],"corrected":[89],"using":[90],"one":[91,134],"principal":[92],"component,":[93],"some":[95],"cryptic":[96],"kinship":[97],"that":[98],"required":[99],"no":[100],"correction.":[101],"NKAIN2":[102],"showed":[103,119],"suggestive":[104,120],"evidence":[105,121],"as":[110],"main":[112],"(p":[114,126],"<":[115],"10(-6))":[116],"GPC6":[118],"interaction":[123],"age":[125],"approximately":[127],"=":[128],"10(-7)).":[129],"support":[132],"previously-reported":[135],"(PDE4D),":[137],"but":[138],"failed":[139],"replicate":[141],"other":[142],"recent":[143],"reports.":[144],"These":[145],"results":[146,174],"suggest":[147],"common":[148],"SNP":[149],"variation":[150],"does":[151],"not":[152],"strongly":[153],"influence":[154],"neuroticism.":[155,186],"Our":[156],"powered":[159],"detect":[161],"almost":[162],"all":[163],"explaining":[165],"at":[166],"least":[167],"2%":[168],"heritability,":[170],"so":[172],"our":[173],"effectively":[175],"exclude":[176],"existence":[178],"loci":[180],"having":[181],"on":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
