{"id":"https://openalex.org/W2004806217","doi":"https://doi.org/10.1016/s1507-1367(05)71081-6","title":"Estimation of relative biological effectiveness of 6 and 22 MeV neutrons and 137Cs \u03b3-rays based on the analysis of chromosome aberrations in human peripheral blood lymphocytes","display_name":"Estimation of relative biological effectiveness of 6 and 22 MeV neutrons and 137Cs \u03b3-rays based on the analysis of chromosome aberrations in human peripheral blood lymphocytes","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2004806217","doi":"https://doi.org/10.1016/s1507-1367(05)71081-6","mag":"2004806217"},"language":"en","primary_location":{"id":"doi:10.1016/s1507-1367(05)71081-6","doi":"https://doi.org/10.1016/s1507-1367(05)71081-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1507-1367(05)71081-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1507136705710816/pdf","source":{"id":"https://openalex.org/S168508312","display_name":"Reports of Practical Oncology & Radiotherapy","issn_l":"1428-2267","issn":["1428-2267","1507-1367","2083-4640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports of Practical Oncology & Radiotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1507136705710816/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088296441","display_name":"Emilia A. Dyomina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Emilia A. Dyomina","raw_affiliation_strings":["Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Department of Radiobiology, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Department of Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041216787","display_name":"Natalia M. Ryabchenko","orcid":"https://orcid.org/0000-0003-1771-8484","observed_orcids":["https://orcid.org/0000-0003-1771-8484"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Natalia M. Ryabchenko","raw_affiliation_strings":["Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Department of Radiobiology, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Department of Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062542623","display_name":"Volodymyr M. Voitsitskyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Volodymyr M. Voitsitskyi","raw_affiliation_strings":["Kyiv T. Shevchenko National University, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyiv T. Shevchenko National University, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057282975","display_name":"Svitlana V. Hiznyak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Svitlana V. Hiznyak","raw_affiliation_strings":["Kyiv T. Shevchenko National University, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyiv T. Shevchenko National University, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041216787"],"corresponding_institution_ids":["https://openalex.org/I4210113428"],"apc_list":{"value":1500,"currency":"EUR","value_usd":1713},"apc_paid":{"value":1500,"currency":"EUR","value_usd":1713},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"1","first_page":"43","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.10909999907016754,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.996999979019165},{"id":"https://openalex.org/keywords/fast-neutrons","display_name":"fast neutrons","score":0.8169999718666077},{"id":"https://openalex.org/keywords/137cs-gamma-rays","display_name":"137Cs gamma rays","score":0.8510000109672546},{"id":"https://openalex.org/keywords/60co-gamma-rays","display_name":"60Co gamma rays","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9539999961853027},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cytogenetic-dosimetry","display_name":"cytogenetic dosimetry","score":0.9660000205039978},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/dose-dependence","display_name":"dose dependence","score":0.7850000262260437},{"id":"https://openalex.org/keywords/depth-dose","display_name":"depth dose","score":0.42500001192092896},{"id":"https://openalex.org/keywords/water-phantom","display_name":"water phantom","score":0.6349999904632568},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.7779677510261536},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.7243642807006836},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7068852782249451},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.6443691253662109},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6440624594688416},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6164143681526184},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.5732501149177551},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.511622965335846},{"id":"https://openalex.org/C27251351","wikidata":"https://www.wikidata.org/wiki/Q1969703","display_name":"Neutron temperature","level":3,"score":0.4413033425807953},{"id":"https://openalex.org/C2994296024","wikidata":"https://www.wikidata.org/wiki/Q744962","display_name":"Chromosome aberration","level":4,"score":0.44105058908462524},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.4199313521385193},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.38170674443244934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31006160378456116},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2788202464580536},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.27127715945243835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24196311831474304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19736889004707336},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.19595867395401},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10765784978866577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08492743968963623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1507-1367(05)71081-6","doi":"https://doi.org/10.1016/s1507-1367(05)71081-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1507-1367(05)71081-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1507136705710816/pdf","source":{"id":"https://openalex.org/S168508312","display_name":"Reports of Practical Oncology & Radiotherapy","issn_l":"1428-2267","issn":["1428-2267","1507-1367","2083-4640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports of Practical Oncology & Radiotherapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s1507-1367(05)71081-6","doi":"https://doi.org/10.1016/s1507-1367(05)71081-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1507-1367(05)71081-6","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1507136705710816/pdf","source":{"id":"https://openalex.org/S168508312","display_name":"Reports of Practical Oncology & Radiotherapy","issn_l":"1428-2267","issn":["1428-2267","1507-1367","2083-4640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports of Practical Oncology & Radiotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004806217.pdf","grobid_xml":"https://content.openalex.org/works/W2004806217.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2050361501","https://openalex.org/W2079937000","https://openalex.org/W2102080012","https://openalex.org/W2108408315","https://openalex.org/W2397705523","https://openalex.org/W2416940483"],"related_works":["https://openalex.org/W2440020977","https://openalex.org/W2415287415","https://openalex.org/W4410564189","https://openalex.org/W2012356609","https://openalex.org/W2084941636","https://openalex.org/W2198347301","https://openalex.org/W2371492075","https://openalex.org/W2137421657","https://openalex.org/W4233542918","https://openalex.org/W1994048061"],"abstract_inverted_index":{"This":[0],"investigation":[1],"presents":[2],"the":[3,17,31,42,86,98,109,155,158,161,170,198,201],"estimation":[4,119],"of":[5,21,27,33,55,70,81,88,120,134,160,172,179,200,213],"cytogenetic":[6,147],"injury":[7],"in":[8,25,41,76,85,100,108,116,157,211],"human":[9,56],"peripheral":[10],"blood":[11],"lymphocytes":[12],"and":[13,19,61,65,72,197],"its":[14],"dependence":[15],"on":[16,189],"dose":[18,43,77,112],"quality":[20],"ionizing":[22],"radiation":[23,39],"applied":[24],"radiotherapy":[26,212],"cancer":[28,214],"patients":[29],"with":[30,67,139,154],"purpose":[32],"calculating":[34],"RBE":[35,79,101,123],"values":[36,80,102,124],"for":[37],"different":[38,190],"sources":[40,64],"range":[44,87],"under":[45],"study.":[46],"Cytogenetic":[47],"dosimetry":[48],"was":[49,144,167],"carried":[50],"out":[51],"at":[52,169],"an":[53],"exposure":[54],"lymphocyte":[57],"cultures":[58],"to":[59,152,174],"137Cs":[60,82],"60Co":[62],"therapeutic":[63],"neutrons":[66,129],"average":[68],"energies":[69],"6":[71,127,175],"22":[73,140],"MeV.":[74],"Increase":[75],"reduces":[78],"\u03b3-irradiation,":[83],"which":[84,205],"doses":[89],"investigated":[90],"(0.3\u20135.0":[91],"Gy)":[92],"vary":[93],"between":[94],"3.5\u20131.3,":[95],"respectively.":[96],"Thus":[97],"difference":[99],"can":[103],"be":[104,207],"most":[105],"accurately":[106],"determined":[107],"0.5\u20132.0":[110],"Gy":[111],"interval":[113],"usually":[114],"used":[115],"radiotherapy.":[117],"Comparative":[118],"fast":[121],"neutron":[122],"showed":[125],"that":[126,146,184],"MeV":[128],"give":[130],"significantly":[131],"higher":[132],"yields":[133],"chromosome":[135],"aberrations":[136],"as":[137,194],"compared":[138],"Mev":[141],"neutrons.":[142],"It":[143],"shown":[145],"effectiveness":[148],"has":[149],"a":[150],"tendency":[151],"decrease":[153],"increase":[156],"depth":[159,171,199],"water":[162],"phantom.":[163],"The":[164,177],"largest":[165],"effect":[166],"observed":[168],"up":[173],"cm.":[176],"results":[178],"our":[180],"pre-clinical":[181],"studies":[182],"indicate":[183],"radiation-induced":[185],"effects":[186],"simultaneously":[187],"depend":[188],"irradiation":[191],"parameters":[192],"such":[193],"dose,":[195],"energy":[196],"irradiated":[202],"biological":[203],"object,":[204],"should":[206],"taken":[208],"into":[209],"account":[210],"patients.":[215]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}