{"id":"https://openalex.org/W2004804616","doi":"https://doi.org/10.1080/01483918408073998","title":"The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives","display_name":"The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2004804616","doi":"https://doi.org/10.1080/01483918408073998","mag":"2004804616"},"language":"en","primary_location":{"id":"doi:10.1080/01483918408073998","doi":"https://doi.org/10.1080/01483918408073998","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01483918408073998","pdf_url":null,"source":{"id":"https://openalex.org/S4210197900","display_name":"Journal of Liquid Chromatography","issn_l":"0148-3919","issn":["0148-3919","2331-0413"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073267357","display_name":"Irving W. Wainer","orcid":"https://orcid.org/0000-0003-1643-5845","observed_orcids":["https://orcid.org/0000-0003-1643-5845"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irving W. Wainer","raw_affiliation_strings":["Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033015115","display_name":"Thomas D. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Doyle","raw_affiliation_strings":["Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045340047","display_name":"Christopher D. Breder","orcid":"https://orcid.org/0000-0002-1902-1595","observed_orcids":["https://orcid.org/0000-0002-1902-1595","https://orcid.org/0000-0002-8874-3401"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Breder","raw_affiliation_strings":["Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Chemistry, Food and Drug Administration, Washington, DC, 20204","institution_ids":["https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1320320070"],"apc_list":null,"apc_paid":null,"fwci":1.658,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79492731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"4","first_page":"731","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-stationary-phase","display_name":"chiral stationary phase","score":0.7210000157356262},{"id":"https://openalex.org/keywords/enantiomeric-separation","display_name":"enantiomer separation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tropicamide","display_name":"tropicamide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/amide-derivatives","display_name":"amide derivatives","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ester-derivatives","display_name":"ester derivatives","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phenylglycine-derivatives","display_name":"phenylglycine derivatives","score":0.6779999732971191},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7749322056770325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7640079259872437},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.7606051564216614},{"id":"https://openalex.org/C2993377673","wikidata":"https://www.wikidata.org/wiki/Q5101828","display_name":"Chiral stationary phase","level":3,"score":0.7547692060470581},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6099362373352051},{"id":"https://openalex.org/C16838498","wikidata":"https://www.wikidata.org/wiki/Q5101828","display_name":"Chiral column chromatography","level":3,"score":0.588566780090332},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5772358775138855},{"id":"https://openalex.org/C2780472037","wikidata":"https://www.wikidata.org/wiki/Q29310","display_name":"Tropicamide","level":3,"score":0.5496559739112854},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.48710179328918457},{"id":"https://openalex.org/C2983406500","wikidata":"https://www.wikidata.org/wiki/Q7604347","display_name":"Stationary phase","level":2,"score":0.45009076595306396},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4280412495136261},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.41520076990127563},{"id":"https://openalex.org/C47849319","wikidata":"https://www.wikidata.org/wiki/Q5101829","display_name":"Chiral derivatizing agent","level":4,"score":0.41280269622802734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/01483918408073998","doi":"https://doi.org/10.1080/01483918408073998","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01483918408073998","pdf_url":null,"source":{"id":"https://openalex.org/S4210197900","display_name":"Journal of Liquid Chromatography","issn_l":"0148-3919","issn":["0148-3919","2331-0413"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.49000000953674316}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1990272114","https://openalex.org/W2015812182","https://openalex.org/W2020811912","https://openalex.org/W2031673298","https://openalex.org/W2492000367"],"related_works":["https://openalex.org/W1593292590","https://openalex.org/W1985465005","https://openalex.org/W2016794021","https://openalex.org/W2767194166","https://openalex.org/W2004040714","https://openalex.org/W2372190716","https://openalex.org/W2111834926","https://openalex.org/W1996256517","https://openalex.org/W1981249939","https://openalex.org/W1985408286"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,7],"amide":[3,25],"and":[4],"ester":[5,38],"derivatives":[6],"tropic":[8],"acid":[9],"were":[10,31,42],"chromatographed":[11],"by":[12],"using":[13],"a":[14],"commercially":[15],"available":[16],"covalently":[17],"bonded":[18],"HPLC":[19],"chiral":[20],"stationary":[21],"phase,":[22],"(R)-N-(3,5-dinitrobenzoyl)-phenylglycine.":[23],"The":[24],"derivatives,":[26,39],"including":[27,40],"pharmacologically":[28],"important":[29],"tropicamide,":[30],"resolved":[32],"on":[33],"this":[34],"column,":[35],"but":[36],"the":[37],"atropine,":[41],"not.":[43]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}