{"id":"https://openalex.org/W2004803703","doi":"https://doi.org/10.1073/pnas.93.23.12947","title":"Efficiency of DNA replication in the polymerase chain reaction","display_name":"Efficiency of DNA replication in the polymerase chain reaction","publication_year":1996,"publication_date":"1996-11-12","ids":{"openalex":"https://openalex.org/W2004803703","doi":"https://doi.org/10.1073/pnas.93.23.12947","mag":"2004803703","pmid":"https://pubmed.ncbi.nlm.nih.gov/8917524","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/24026"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.93.23.12947","doi":"https://doi.org/10.1073/pnas.93.23.12947","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.23.12947","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC24026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000065699","display_name":"Gustavo A. Stolovitzky","orcid":"https://orcid.org/0000-0002-9618-2819","observed_orcids":["https://orcid.org/0000-0002-9618-2819"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Stolovitzky","raw_affiliation_strings":["Center for Studies in Physics and Biology, The Rockefeller\r University, 1230 York Avenue, New York NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller\r University, 1230 York Avenue, New York NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065396462","display_name":"Guillermo Cecchi","orcid":"https://orcid.org/0000-0003-1013-8348","observed_orcids":["https://orcid.org/0000-0003-1013-8348"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Cecchi","raw_affiliation_strings":["Center for Studies in Physics and Biology, The Rockefeller\r University, 1230 York Avenue, New York NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller\r University, 1230 York Avenue, New York NY 10021","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":0.5049,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.60572564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"93","issue":"23","first_page":"12947","last_page":"12952"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11152","display_name":"Stochastic processes and statistical mechanics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2610","display_name":"Mathematical Physics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcr","display_name":"PCR","score":0.921999990940094},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.796999990940094},{"id":"https://openalex.org/keywords/kinetic-model","display_name":"kinetic model","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pcr-cycle-number","display_name":"PCR cycle number","score":0.7570000290870667},{"id":"https://openalex.org/keywords/multimodality","display_name":"multimodality","score":0.8349999785423279},{"id":"https://openalex.org/keywords/scaling-behavior","display_name":"scaling behavior","score":0.9919999837875366},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.6834365725517273},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.5646246075630188},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5642157196998596},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.548444390296936},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5112826824188232},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4564914107322693},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.4514370262622833},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4465107321739197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40996086597442627},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40464460849761963},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29296913743019104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11901697516441345},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0828312337398529}],"mesh":[{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.93.23.12947","doi":"https://doi.org/10.1073/pnas.93.23.12947","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.23.12947","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:191012","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC24026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:24026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:8917524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8917524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:191012","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC24026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1517480469","https://openalex.org/W1972061284","https://openalex.org/W1977312644","https://openalex.org/W1980570931","https://openalex.org/W1990083018","https://openalex.org/W1999052302","https://openalex.org/W2001530093","https://openalex.org/W2051840225","https://openalex.org/W2057392561","https://openalex.org/W2068130878","https://openalex.org/W2079177275","https://openalex.org/W2079851474","https://openalex.org/W2089898350","https://openalex.org/W2093009120","https://openalex.org/W2102787760","https://openalex.org/W2137371141","https://openalex.org/W2144634347","https://openalex.org/W2314225431","https://openalex.org/W2568511220","https://openalex.org/W2751862591","https://openalex.org/W4244638572","https://openalex.org/W4297962570","https://openalex.org/W4301441647"],"related_works":["https://openalex.org/W2291427620","https://openalex.org/W2951782230","https://openalex.org/W7098877752","https://openalex.org/W1670970707","https://openalex.org/W2895498807","https://openalex.org/W7096806427","https://openalex.org/W2002440736","https://openalex.org/W2158274955","https://openalex.org/W2086904999","https://openalex.org/W2060161932"],"abstract_inverted_index":{"A":[0],"detailed":[1],"quantitative":[2,97,104],"kinetic":[3],"model":[4,95],"for":[5,96],"the":[6,18,29,34,40,43,62,65,75,78,94],"polymerase":[7],"chain":[8],"reaction":[9],"(PCR)":[10],"is":[11,59,99,107],"developed,":[12],"which":[13,49],"allows":[14],"us":[15],"to":[16,55],"predict":[17],"probability":[19,51],"of":[20,22,28,39,42,45,64,69,77,80,86,93],"replication":[21],"a":[23,57,83,102],"DNA":[24],"molecule":[25],"in":[26,33,74],"terms":[27],"physical":[30],"parameters":[31],"involved":[32],"system.":[35],"The":[36,91],"important":[37],"issue":[38],"determination":[41],"number":[44,79,85],"PCR":[46,87,98,105],"cycles":[47,88],"during":[48],"this":[50],"can":[52],"be":[53,56],"considered":[54],"constant":[58],"solved":[60],"within":[61],"framework":[63],"model.":[66],"New":[67],"phenomena":[68],"multimodality":[70],"and":[71,101],"scaling":[72],"behavior":[73],"distribution":[76],"molecules":[81],"after":[82],"given":[84],"are":[89],"presented.":[90],"relevance":[92],"discussed,":[100],"novel":[103],"technique":[106],"proposed.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
