{"id":"https://openalex.org/W2004800370","doi":"https://doi.org/10.1042/cbi20100568","title":"Epigenetic inactivation of PCDH10 in human prostate cancer cell lines","display_name":"Epigenetic inactivation of PCDH10 in human prostate cancer cell lines","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2004800370","doi":"https://doi.org/10.1042/cbi20100568","mag":"2004800370","pmid":"https://pubmed.ncbi.nlm.nih.gov/21314642"},"language":"en","primary_location":{"id":"doi:10.1042/cbi20100568","doi":"https://doi.org/10.1042/cbi20100568","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cbi20100568","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044786927","display_name":"Zesong Li","orcid":"https://orcid.org/0000-0003-0975-4434","observed_orcids":["https://orcid.org/0000-0003-0975-4434"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zesong Li","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen, Peoples Republic of China","Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China","Zesong Li and Wenjie Li contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210164332"]},{"raw_affiliation_string":"Zesong Li and Wenjie Li contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408979","display_name":"Wenjie Li","orcid":"https://orcid.org/0000-0002-1413-0928","observed_orcids":["https://orcid.org/0000-0002-1413-0928"]},"institutions":[{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]},{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjie Li","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","Shantou University Medical College, Shantou 515041, Peoples Republic of China","Zesong Li and Wenjie Li contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Shantou University Medical College, Shantou 515041, Peoples Republic of China","institution_ids":["https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Zesong Li and Wenjie Li contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054971735","display_name":"Jun Xie","orcid":"https://orcid.org/0000-0001-5267-9463","observed_orcids":["https://orcid.org/0000-0001-5267-9463"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Xie","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595919","display_name":"Yong Wang","orcid":"https://orcid.org/0009-0001-0305-2995","observed_orcids":["https://orcid.org/0009-0001-0305-2995"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Wang","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022518485","display_name":"Aifa Tang","orcid":"https://orcid.org/0000-0002-7516-0506","observed_orcids":["https://orcid.org/0000-0002-7516-0506"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aifa Tang","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210164332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022462139","display_name":"Xianxin Li","orcid":"https://orcid.org/0000-0002-5690-0150","observed_orcids":["https://orcid.org/0000-0002-5690-0150"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianxin Li","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019031973","display_name":"Jiongxian Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiongxian Ye","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033259469","display_name":"Yaoting Gui","orcid":"https://orcid.org/0000-0002-5299-8330","observed_orcids":["https://orcid.org/0000-0002-5299-8330","https://orcid.org/0000-0002-6714-0193"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yaoting Gui","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","Zesong Li and Wenjie Li contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Zesong Li and Wenjie Li contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065049479","display_name":"Zhiming Cai","orcid":"https://orcid.org/0000-0002-2602-4786","observed_orcids":["https://orcid.org/0000-0002-2602-4786","https://orcid.org/0000-0002-2966-4367","https://orcid.org/0000-0002-7168-6332"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiming Cai","raw_affiliation_strings":["Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China","Zesong Li and Wenjie Li contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKUHKUST Medical Center, Shenzhen 518036, Peoples Republic of China","institution_ids":["https://openalex.org/I4210128628"]},{"raw_affiliation_string":"Shenzhen Second Peoples Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Peoples Republic of China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210164332"]},{"raw_affiliation_string":"Zesong Li and Wenjie Li contributed equally to this work","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033259469","https://openalex.org/A5044786927","https://openalex.org/A5065049479","https://openalex.org/A5100408979"],"corresponding_institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210120522","https://openalex.org/I4210128628","https://openalex.org/I4210164332"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":1.2839,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77547469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"35","issue":"7","first_page":"671","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcdh10","display_name":"PCDH10","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7850000262260437},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.8700000047683716},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.6680060625076294},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.6419994831085205},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6365554332733154},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6298562288284302},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6156593561172485},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5592437386512756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.546831488609314},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.44303369522094727},{"id":"https://openalex.org/C163911330","wikidata":"https://www.wikidata.org/wiki/Q7251899","display_name":"Protocadherin","level":4,"score":0.4365035891532898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4330659806728363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35489997267723083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34541550278663635},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3265931010246277},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3227873742580414},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26408565044403076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17297926545143127},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.15315592288970947},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.11871695518493652},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.062362462282180786}],"mesh":[{"descriptor_ui":"D000091363","descriptor_name":"Protocadherins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003568","descriptor_name":"Cytidine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003568","descriptor_name":"Cytidine Monophosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cbi20100568","doi":"https://doi.org/10.1042/cbi20100568","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cbi20100568","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:21314642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21314642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1963592300","https://openalex.org/W1965086698","https://openalex.org/W2010736881","https://openalex.org/W2015576439","https://openalex.org/W2034356514","https://openalex.org/W2055294254","https://openalex.org/W2056939323","https://openalex.org/W2062985556","https://openalex.org/W2063965661","https://openalex.org/W2070166913","https://openalex.org/W2085819466","https://openalex.org/W2094887125","https://openalex.org/W2107277218","https://openalex.org/W2133918562","https://openalex.org/W2135946283","https://openalex.org/W2139122477","https://openalex.org/W2153003353","https://openalex.org/W2155268176","https://openalex.org/W2155680682","https://openalex.org/W2158778721","https://openalex.org/W2169550012","https://openalex.org/W2170222791"],"related_works":["https://openalex.org/W2007563559","https://openalex.org/W1970610738","https://openalex.org/W896146072","https://openalex.org/W2047413381","https://openalex.org/W3007221536","https://openalex.org/W2028124085","https://openalex.org/W2056939323","https://openalex.org/W4310143962","https://openalex.org/W2055294254","https://openalex.org/W2382848062"],"abstract_inverted_index":{"PCDH10":[0,27,42,58,76,86,95,99,120,134,147,161],"(protocadherin-10),":[1],"a":[2,35],"novel":[3],"tumour":[4],"suppressor":[5],"gene,":[6],"is":[7],"down-regulated":[8],"in":[9,28,34,46,52,64,102,136,163],"several":[10],"human":[11],"cancers":[12],"due":[13],"to":[14,154],"hypermethylation":[15],"of":[16,26,37,57,84,119,125,146,157,160,166],"promoter":[17,100,148],"CGIs":[18],"(CpG":[19],"islands).":[20],"Here,":[21],"we":[22,129],"investigated":[23],"the":[24,53,81,85,89,117,123,132,143,155,158,164],"expression":[25,56,77,96,118,135],"different":[29],"normal":[30,47,71],"adult":[31,72],"tissues":[32,48],"and":[33],"panel":[36],"prostate":[38,65,73,103,137,167],"cancer":[39,66,104,138],"cell":[40,67,105],"lines.":[41,106],"was":[43,59,78,140],"widely":[44],"expressed":[45],"with":[49,70,80,108,142],"higher":[50],"levels":[51],"prostate.":[54],"The":[55],"markedly":[60],"reduced":[61],"or":[62],"silenced":[63],"lines":[68],"compared":[69],"tissue.":[74],"Decreased":[75],"correlated":[79],"methylation":[82,101,145],"status":[83],"promoter.":[87],"Furthermore,":[88],"DNA":[90],"demethylating":[91],"agent":[92],"5'-azacytidin":[93],"restored":[94],"by":[97],"suppressing":[98],"Treatment":[107],"Trichostatin":[109],"A":[110],"alone":[111],"had":[112],"no":[113],"significant":[114],"effect":[115,124],"on":[116],"but":[121],"enhanced":[122],"5'-azacytidin.":[126],"In":[127],"conclusion,":[128],"found":[130],"that":[131],"decreased":[133],"cells":[139],"associated":[141],"aberrant":[144],"CGI.":[149],"Our":[150],"results":[151],"may":[152],"contribute":[153],"understanding":[156],"role":[159],"inactivation":[162],"progression":[165],"cancers.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
