{"id":"https://openalex.org/W2004772056","doi":"https://doi.org/10.1179/136485909x384929","title":"Mansonella perstans: safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination","display_name":"Mansonella perstans: safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2004772056","doi":"https://doi.org/10.1179/136485909x384929","mag":"2004772056","pmid":"https://pubmed.ncbi.nlm.nih.gov/19173774"},"language":"en","primary_location":{"id":"doi:10.1179/136485909x384929","doi":"https://doi.org/10.1179/136485909x384929","is_oa":false,"landing_page_url":"https://doi.org/10.1179/136485909x384929","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075456843","display_name":"Santa Maria Asio","orcid":"https://orcid.org/0009-0008-6270-5133","observed_orcids":["https://orcid.org/0009-0008-6270-5133"]},"institutions":[{"id":"https://openalex.org/I43480833","display_name":"Kyambogo University","ror":"https://ror.org/01wb6tr49","country_code":"UG","type":"education","lineage":["https://openalex.org/I43480833"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"S. M. Asio","raw_affiliation_strings":["Kyambogo University, Kyambogo, Kampala, Uganda","Kyambogo University, P.O. Box 1, Kyambogo, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyambogo University, Kyambogo, Kampala, Uganda","institution_ids":["https://openalex.org/I43480833"]},{"raw_affiliation_string":"Kyambogo University, P.O. Box 1, Kyambogo, Kampala, Uganda","institution_ids":["https://openalex.org/I43480833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111573336","display_name":"Paul E. Simonsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P. E. Simonsen","raw_affiliation_strings":["DBL \u2014 Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DBL \u2014 Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112037461","display_name":"Ambrose W. Onapa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092895","display_name":"Ministry of Health","ror":"https://ror.org/00hy3gq97","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210092895"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"A. W. Onapa","raw_affiliation_strings":["Vector Control Division Ministry of Health, P.O. Box 1661, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vector Control Division Ministry of Health, P.O. Box 1661, Kampala, Uganda","institution_ids":["https://openalex.org/I4210092895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8468,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.83430697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"103","issue":"1","first_page":"31","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mansonella-perstans","display_name":"Mansonella perstans","score":1.0},{"id":"https://openalex.org/keywords/ivermectin","display_name":"ivermectin","score":0.953000009059906},{"id":"https://openalex.org/keywords/albendazole","display_name":"albendazole","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/microfilaremia","display_name":"microfilaremia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antiparasitic-efficacy","display_name":"antiparasitic drug efficacy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9079999923706055},{"id":"https://openalex.org/keywords/single-dose-treatment","display_name":"single-dose therapy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/onchocerciasis","display_name":"onchocerciasis","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2777065887","wikidata":"https://www.wikidata.org/wiki/Q411629","display_name":"Albendazole","level":2,"score":0.9518649578094482},{"id":"https://openalex.org/C2777499811","wikidata":"https://www.wikidata.org/wiki/Q415178","display_name":"Ivermectin","level":2,"score":0.9492448568344116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6913325190544128},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.493569016456604},{"id":"https://openalex.org/C2776908094","wikidata":"https://www.wikidata.org/wiki/Q572294","display_name":"Anthelmintic","level":2,"score":0.4707130789756775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4375455975532532},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4218716025352478},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41237926483154297},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31374043226242065},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.1810152232646942}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008366","descriptor_name":"Mansonella","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008368","descriptor_name":"Mansonelliasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014454","descriptor_name":"Uganda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015766","descriptor_name":"Albendazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015766","descriptor_name":"Albendazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1179/136485909x384929","doi":"https://doi.org/10.1179/136485909x384929","is_oa":false,"landing_page_url":"https://doi.org/10.1179/136485909x384929","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"},{"id":"pmid:19173774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19173774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of tropical medicine and parasitology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e67c7000-1a0f-11de-b43e-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e67c7000-1a0f-11de-b43e-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asio, S M, Simonsen, P E & Onapa, A W 2009, 'Mansonella perstans : safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination', Annals of Tropical Medicine and Parasitology, vol. 103, no. 1, pp. 31-37. https://doi.org/10.1179/136485909X384929","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W24436973","https://openalex.org/W133097400","https://openalex.org/W155990156","https://openalex.org/W1520999598","https://openalex.org/W1966539028","https://openalex.org/W2002294574","https://openalex.org/W2012773720","https://openalex.org/W2026537523","https://openalex.org/W2027462237","https://openalex.org/W2033777457","https://openalex.org/W2045739590","https://openalex.org/W2084706583","https://openalex.org/W2164742441","https://openalex.org/W2166497441","https://openalex.org/W2217913714","https://openalex.org/W2289257421","https://openalex.org/W2299036071","https://openalex.org/W2299515544","https://openalex.org/W2314515855","https://openalex.org/W4211118254","https://openalex.org/W4302155074","https://openalex.org/W6777773778"],"related_works":["https://openalex.org/W2155474928","https://openalex.org/W2079410080","https://openalex.org/W2164742441","https://openalex.org/W2027462237","https://openalex.org/W24436973","https://openalex.org/W2137254078","https://openalex.org/W2035937787","https://openalex.org/W2026537523","https://openalex.org/W2078987306","https://openalex.org/W1966539028"],"abstract_inverted_index":{"The":[0,130],"safety":[1],"and":[2,41,60,104,107],"efficacy":[3],"of":[4,8,21,32,69,148],"a":[5],"single":[6],"dose":[7],"ivermectin":[9,75],"alone":[10,15,76],"(150-200":[11],"microg/kg":[12],"bodyweight),":[13],"albendazole":[14,78],"(400":[16],"mg)":[17],"or":[18,52,77,116],"the":[19,55,66,72,80,91,97,125,146],"combination":[20],"these":[22],"two":[23,126],"drugs":[24],"was":[25],"assessed,":[26],"in":[27,29,44,124,145],"Uganda,":[28],"three":[30,131],"groups":[31,128],"individuals":[33],"infected":[34],"with":[35],"Mansonella":[36],"perstans":[37,150],"(with":[38],"15,":[39],"13":[40],"15":[42],"subjects":[43,73,92],"each":[45],"group,":[46],"respectively).":[47],"No":[48],"side-effects":[49],"were":[50,120,136],"observed":[51],"reported":[53],"during":[54,65],"first":[56],"7":[57],"days":[58],"post-treatment":[59,110],"every":[61],"subject":[62],"remained":[63,84],"microfilaraemic":[64],"12":[67,117],"months":[68,109],"follow-up.":[70],"In":[71,90],"given":[74,93],"alone,":[79],"microfilarial":[81,98],"intensities":[82,99],"consistently":[83],"close":[85],"to":[86],"their":[87],"pre-treatment":[88],"levels.":[89],"both":[94],"drugs,":[95],"however,":[96],"decreased":[100],"slightly":[101],"after":[102],"treatment":[103,147],"at":[105,113],"1":[106],"3":[108],"(but":[111],"not":[112],"6,":[114],"9":[115],"months)":[118],"they":[119],"significantly":[121],"lower":[122],"than":[123],"other":[127],"combined.":[129],"single-dose":[132],"drug":[133],"regimens":[134],"investigated":[135],"thus":[137],"well":[138],"tolerated":[139],"but":[140],"had":[141],"disappointingly":[142],"low":[143],"efficacies":[144],"M.":[149],"microfilaraemias.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
