{"id":"https://openalex.org/W2004771972","doi":"https://doi.org/10.1080/10731190802554380","title":"Impact of Oxygenation of Bioartificial Liver Using Perfluorocarbon Emulsion Perftoran on Metabolism of Human Hepatoma C3A Cells","display_name":"Impact of Oxygenation of Bioartificial Liver Using Perfluorocarbon Emulsion Perftoran on Metabolism of Human Hepatoma C3A Cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2004771972","doi":"https://doi.org/10.1080/10731190802554380","mag":"2004771972","pmid":"https://pubmed.ncbi.nlm.nih.gov/19101829"},"language":"en","primary_location":{"id":"doi:10.1080/10731190802554380","doi":"https://doi.org/10.1080/10731190802554380","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10731190802554380","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10731190802554380?download=true","source":{"id":"https://openalex.org/S159739878","display_name":"Artificial Cells Blood Substitutes and Biotechnology","issn_l":"1055-7172","issn":["1055-7172","1073-1199","1532-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Cells, Blood Substitutes, and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/10731190802554380?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032424413","display_name":"Andrzej Kinasiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159312","display_name":"Institute of Biocybernetics and Biomedical Engineering","ror":"https://ror.org/05f8zcs55","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Andrzej Kinasiewicz","raw_affiliation_strings":["Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4, Warsaw, Poland. kinas@ibib.waw.pl","Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4, Warsaw, Poland. kinas@ibib.waw.pl","institution_ids":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4, Warsaw, Poland","institution_ids":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024332506","display_name":"Anna Grzeczkowicz","orcid":"https://orcid.org/0000-0002-8970-4578","observed_orcids":["https://orcid.org/0000-0002-8970-4578"]},"institutions":[{"id":"https://openalex.org/I4210159312","display_name":"Institute of Biocybernetics and Biomedical Engineering","ror":"https://ror.org/05f8zcs55","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna \u015amietanka","raw_affiliation_strings":["Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040696914","display_name":"B Gajkowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Barbara Gajkowska","raw_affiliation_strings":["Department of Cell Ultrastructure, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Ultrastructure, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011006721","display_name":"Andrzej Wery\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159312","display_name":"Institute of Biocybernetics and Biomedical Engineering","ror":"https://ror.org/05f8zcs55","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Wery\u0144ski","raw_affiliation_strings":["Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210159312","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032424413"],"corresponding_institution_ids":["https://openalex.org/I4210159312","https://openalex.org/I99542240"],"apc_list":null,"apc_paid":null,"fwci":1.7568,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84598231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"6","first_page":"525","last_page":"534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioartificial-liver","display_name":"bioartificial liver","score":0.9950000047683716},{"id":"https://openalex.org/keywords/perfluorocarbon-emulsions","display_name":"perfluorocarbon emulsions","score":0.9660000205039978},{"id":"https://openalex.org/keywords/perftoran","display_name":"perftoran","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxygen-carriers","display_name":"oxygen carriers","score":0.7020000219345093},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.550000011920929},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.5770000219345093},{"id":"https://openalex.org/keywords/bioreactors","display_name":"bioreactors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.8849999904632568},{"id":"https://openalex.org/keywords/albumin-synthesis","display_name":"albumin synthesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C71867830","wikidata":"https://www.wikidata.org/wiki/Q17103308","display_name":"Bioartificial liver device","level":4,"score":0.9298629760742188},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7753770351409912},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.7633719444274902},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6845043897628784},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.6498064994812012},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6229016184806824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5162606239318848},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.48279035091400146},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47702476382255554},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46503087878227234},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.42132091522216797},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3309524953365326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33058345317840576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23008784651756287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18820521235466003},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001802","descriptor_name":"Blood Substitutes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019164","descriptor_name":"Liver, Artificial","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10731190802554380","doi":"https://doi.org/10.1080/10731190802554380","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10731190802554380","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10731190802554380?download=true","source":{"id":"https://openalex.org/S159739878","display_name":"Artificial Cells Blood Substitutes and Biotechnology","issn_l":"1055-7172","issn":["1055-7172","1073-1199","1532-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Cells, Blood Substitutes, and Biotechnology","raw_type":"journal-article"},{"id":"pmid:19101829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19101829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial cells, blood substitutes, and immobilization biotechnology","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1080/10731190802554380","doi":"https://doi.org/10.1080/10731190802554380","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10731190802554380","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10731190802554380?download=true","source":{"id":"https://openalex.org/S159739878","display_name":"Artificial Cells Blood Substitutes and Biotechnology","issn_l":"1055-7172","issn":["1055-7172","1073-1199","1532-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Cells, Blood Substitutes, and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004771972.pdf","grobid_xml":"https://content.openalex.org/works/W2004771972.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W8170640","https://openalex.org/W53459431","https://openalex.org/W1942726938","https://openalex.org/W1958499971","https://openalex.org/W1964480713","https://openalex.org/W1974860935","https://openalex.org/W1978834836","https://openalex.org/W1992623347","https://openalex.org/W1996354260","https://openalex.org/W2005325337","https://openalex.org/W2066292616","https://openalex.org/W2084076582","https://openalex.org/W2143926676","https://openalex.org/W2152536964","https://openalex.org/W2157859754","https://openalex.org/W2167653209","https://openalex.org/W2169335085","https://openalex.org/W2254695242","https://openalex.org/W4241202476"],"related_works":["https://openalex.org/W1964480713","https://openalex.org/W2068469440","https://openalex.org/W2062297466","https://openalex.org/W2078697261","https://openalex.org/W7065314878","https://openalex.org/W1968762448","https://openalex.org/W303279804","https://openalex.org/W1978834836","https://openalex.org/W125937002","https://openalex.org/W2067697262"],"abstract_inverted_index":{"One":[0],"of":[1,19,26,34,36,47,112,130,143],"the":[2,22,32,44,77,83,104,123,128,135,144,160],"most":[3],"important":[4],"challenges":[5],"in":[6,50,76,82,94,103,159],"bioartificial":[7,37],"liver":[8,15,38],"designed":[9],"for":[10,63,79,156],"patients":[11],"suffering":[12],"from":[13],"acute":[14],"failure":[16],"is":[17],"oxygenation":[18,35],"cells":[20,49,74,158],"within":[21],"bioreactor.":[23,145,161],"The":[24],"aim":[25],"this":[27],"study":[28],"was":[29,92,115],"to":[30],"evaluate":[31],"impact":[33],"using":[39],"perfluorocarbon":[40],"(PFC)":[41],"emulsion":[42],"on":[43],"metabolic":[45],"activity":[46],"hepatic":[48,64,72,157],"vitro.":[51],"Mineral":[52,146],"fibers":[53,147],"coated":[54,148],"with":[55,86,89,96,107,149],"collagen":[56],"type":[57],"I":[58],"were":[59],"used":[60],"as":[61,134,154],"scaffolds":[62],"cells.":[65],"Significantly":[66],"higher":[67,119],"total":[68],"protein":[69],"synthesis":[70],"by":[71],"C3A":[73],"cultured":[75],"bioreactor":[78],"24":[80],"hours,":[81],"group":[84,105],"treated":[85,106],"medium":[87,97],"supplemented":[88],"PFC":[90,108,136],"emulsion,":[91,137],"observed":[93],"comparison":[95],"without":[98],"PFC.":[99],"Albumin":[100],"production":[101],"increased":[102],"after":[109],"1":[110],"hour":[111],"perfusion":[113,121],"and":[114],"continuously,":[116],"statistically,":[117],"significantly":[118,139],"during":[120],"then":[122],"control":[124],"group.":[125],"In":[126],"conclusion,":[127],"use":[129],"oxygen":[131],"carriers,":[132],"such":[133],"can":[138],"improve":[140],"synthetic":[141],"performance":[142],"extracellular":[150],"proteins":[151],"may":[152],"serve":[153],"support":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}