{"id":"https://openalex.org/W2004767160","doi":"https://doi.org/10.1074/jbc.m114.573832","title":"Caenorhabditis elegans Recognizes a Bacterial Quorum-sensing Signal Molecule through the AWCON Neuron","display_name":"Caenorhabditis elegans Recognizes a Bacterial Quorum-sensing Signal Molecule through the AWCON Neuron","publication_year":2014,"publication_date":"2014-08-05","ids":{"openalex":"https://openalex.org/W2004767160","doi":"https://doi.org/10.1074/jbc.m114.573832","mag":"2004767160","pmid":"https://pubmed.ncbi.nlm.nih.gov/25092291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4176233"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m114.573832","doi":"https://doi.org/10.1074/jbc.m114.573832","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.573832","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m114.573832","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058566536","display_name":"Kristen M. Werner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen M. Werner","raw_affiliation_strings":["Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030401635","display_name":"Lark J. Perez","orcid":"https://orcid.org/0000-0002-6920-7996","observed_orcids":["https://orcid.org/0000-0002-6920-7996"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lark J. Perez","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030284017","display_name":"Rajarshi Ghosh","orcid":"https://orcid.org/0000-0001-7368-8940","observed_orcids":["https://orcid.org/0000-0001-7368-8940"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajarshi Ghosh","raw_affiliation_strings":["Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, Texas 77030, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, Texas 77030, and","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037542759","display_name":"Martin F. Semmelhack","orcid":"https://orcid.org/0000-0003-0277-3894","observed_orcids":["https://orcid.org/0000-0003-0277-3894"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin F. Semmelhack","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034726213","display_name":"Bonnie L. Bassler","orcid":"https://orcid.org/0000-0002-0043-746X","observed_orcids":["https://orcid.org/0000-0002-0043-746X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bonnie L. Bassler","raw_affiliation_strings":["Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815. Electronic address: bbassler@princeton.edu","Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544","Howard Hughes Medical Institute, Chevy Chase, Maryland 20815"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815. Electronic address: bbassler@princeton.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology and Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland 20815","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034726213"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I20089843"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.466,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.8070723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"289","issue":"38","first_page":"26566","last_page":"26573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12321","display_name":"Insect Pheromone Research and Control","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9190000295639038},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8320000171661377},{"id":"https://openalex.org/keywords/autoinducers","display_name":"autoinducers","score":0.5659999847412109},{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chemosensory-detection","display_name":"chemosensory detection","score":0.7039999961853027},{"id":"https://openalex.org/keywords/interkingdom-interactions","display_name":"cross-kingdom interactions","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8200623989105225},{"id":"https://openalex.org/C95282255","wikidata":"https://www.wikidata.org/wiki/Q4826353","display_name":"Autoinducer","level":5,"score":0.8093747496604919},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.6984413266181946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6497223377227783},{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.5974177122116089},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5236218571662903},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5136144161224365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43138349056243896},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.37359726428985596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16217482089996338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10981720685958862},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.10475939512252808},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002628","descriptor_name":"Chemoreceptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m114.573832","doi":"https://doi.org/10.1074/jbc.m114.573832","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.573832","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4176233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4176233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:25092291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25092291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m114.573832","doi":"https://doi.org/10.1074/jbc.m114.573832","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.573832","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7480991876","display_name":"Intra- and Inter Species Communication in Bacteria","funder_award_id":"R01GM065859","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W643035040","https://openalex.org/W1526941437","https://openalex.org/W1864026313","https://openalex.org/W1892073444","https://openalex.org/W1944127002","https://openalex.org/W1965404074","https://openalex.org/W1966898292","https://openalex.org/W1968533229","https://openalex.org/W1969494228","https://openalex.org/W1975665511","https://openalex.org/W1976416661","https://openalex.org/W1983904941","https://openalex.org/W1987516720","https://openalex.org/W1991138318","https://openalex.org/W1994462493","https://openalex.org/W1996135784","https://openalex.org/W2011336267","https://openalex.org/W2016402044","https://openalex.org/W2016935145","https://openalex.org/W2026703945","https://openalex.org/W2028226237","https://openalex.org/W2029492971","https://openalex.org/W2032256798","https://openalex.org/W2032583854","https://openalex.org/W2044400161","https://openalex.org/W2050499271","https://openalex.org/W2052986082","https://openalex.org/W2059672533","https://openalex.org/W2061464631","https://openalex.org/W2064416689","https://openalex.org/W2065877884","https://openalex.org/W2067517788","https://openalex.org/W2082213186","https://openalex.org/W2088851910","https://openalex.org/W2090098006","https://openalex.org/W2092111364","https://openalex.org/W2093414625","https://openalex.org/W2094204517","https://openalex.org/W2103359264","https://openalex.org/W2106591558","https://openalex.org/W2112846947","https://openalex.org/W2113585283","https://openalex.org/W2118509956","https://openalex.org/W2121039111","https://openalex.org/W2121071682","https://openalex.org/W2126055663","https://openalex.org/W2128016761","https://openalex.org/W2131036374","https://openalex.org/W2131096375","https://openalex.org/W2142809851","https://openalex.org/W2144640625","https://openalex.org/W2159565935"],"related_works":["https://openalex.org/W1837358566","https://openalex.org/W2068592082","https://openalex.org/W7099201346","https://openalex.org/W3109990830","https://openalex.org/W2072616070","https://openalex.org/W2078939133","https://openalex.org/W2522663332","https://openalex.org/W2059672533","https://openalex.org/W3158706134","https://openalex.org/W3134510878"],"abstract_inverted_index":{"In":[0,25],"a":[1,82,139],"process":[2],"known":[3],"as":[4],"quorum":[5],"sensing,":[6],"bacteria":[7,20],"use":[8],"chemicals":[9,31],"called":[10],"autoinducers":[11,18],"for":[12,34,87],"cell-cell":[13],"communication.":[14],"Population-wide":[15],"detection":[16,29],"of":[17,30,92,118,138],"enables":[19],"to":[21,130],"orchestrate":[22],"collective":[23],"behaviors.":[24],"the":[26,53,61,93,98,109,119,135,143],"animal":[27],"kingdom":[28],"is":[32,48,97,106],"vital":[33],"success":[35],"in":[36,52,70],"locating":[37],"food,":[38],"finding":[39],"hosts,":[40],"and":[41,142],"avoiding":[42],"predators.":[43],"This":[44],"behavior,":[45],"termed":[46,66],"chemotaxis,":[47],"especially":[49],"well":[50],"studied":[51],"nematode":[54,103,144],"Caenorhabditis":[55],"elegans.":[56,72],"Here":[57],"we":[58],"demonstrate":[59],"that":[60,78,147],"Vibrio":[62],"cholerae":[63,77,84],"autoinducer":[64],"(S)-3-hydroxytridecan-4-one,":[65],"CAI-1,":[67],"influences":[68],"chemotaxis":[69],"C.":[71,73,110],"elegans":[74,111],"prefers":[75],"V.":[76,83],"produces":[79],"CAI-1":[80,88,94,105],"over":[81],"mutant":[85],"defective":[86],"production.":[89],"The":[90],"position":[91],"ketone":[95],"moiety":[96],"key":[99],"feature":[100],"driving":[101],"CAI-1-directed":[102],"behavior.":[104],"detected":[107],"by":[108],"amphid":[112,125],"sensory":[113,126],"neuron":[114,146],"AWC(ON).":[115],"Laser":[116],"ablation":[117],"AWC(ON)":[120],"cell,":[121],"but":[122],"not":[123],"other":[124],"neurons,":[127],"abolished":[128],"chemoattraction":[129],"CAI-1.":[131],"These":[132],"analyses":[133],"define":[134],"structural":[136],"features":[137],"bacterial-produced":[140],"signal":[141],"chemosensory":[145],"permit":[148],"cross-kingdom":[149],"interaction.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}