{"id":"https://openalex.org/W2004764439","doi":"https://doi.org/10.3181/0807-rm-220","title":"Monocyte Protein Signatures of Disease Severity in Sickle Cell Anemia","display_name":"Monocyte Protein Signatures of Disease Severity in Sickle Cell Anemia","publication_year":2008,"publication_date":"2008-12-09","ids":{"openalex":"https://openalex.org/W2004764439","doi":"https://doi.org/10.3181/0807-rm-220","mag":"2004764439","pmid":"https://pubmed.ncbi.nlm.nih.gov/19064946","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260531"},"language":"en","primary_location":{"id":"doi:10.3181/0807-rm-220","doi":"https://doi.org/10.3181/0807-rm-220","is_oa":false,"landing_page_url":"https://doi.org/10.3181/0807-rm-220","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000601713","display_name":"Anita Hryniewicz\u2010Jankowska","orcid":"https://orcid.org/0000-0001-6213-5865","observed_orcids":["https://orcid.org/0000-0001-6213-5865"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Hryniewicz-Jankowska","raw_affiliation_strings":["Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Children's Medical Center Dallas, Dallas, Texas 75235","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I162577319","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818263","display_name":"Pankaj K. Choudhary","orcid":"https://orcid.org/0000-0002-0398-7459","observed_orcids":["https://orcid.org/0000-0002-0398-7459"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj K. Choudhary","raw_affiliation_strings":["Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Children's Medical Center Dallas, Dallas, Texas 75235","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I162577319","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109928400","display_name":"Larry P. Ammann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry P. Ammann","raw_affiliation_strings":["Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Children's Medical Center Dallas, Dallas, Texas 75235","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I162577319","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058382205","display_name":"Charles T. Quinn","orcid":"https://orcid.org/0000-0002-2372-2175","observed_orcids":["https://orcid.org/0000-0002-2372-2175"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles T. Quinn","raw_affiliation_strings":["Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Children's Medical Center Dallas, Dallas, Texas 75235","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I162577319","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076232055","display_name":"Steven R. Goodman","orcid":"https://orcid.org/0000-0002-7607-6525","observed_orcids":["https://orcid.org/0000-0002-7607-6525"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Goodman","raw_affiliation_strings":["Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Children's Medical Center Dallas, Dallas, Texas 75235","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080; Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390; Children\u2019s Medical Center Dallas, Dallas, Texas 75235; and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I162577319","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular & Cell Biology, Department of Mathematical Sciences, University of Texas at Dallas, Richardson, Texas 75080","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.2368,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56660456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"234","issue":"2","first_page":"210","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/proteomic-signatures","display_name":"proteomic signatures","score":0.7889999747276306},{"id":"https://openalex.org/keywords/transketolase","display_name":"transketolase","score":0.734000027179718},{"id":"https://openalex.org/keywords/coronin","display_name":"coronin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fos","display_name":"FOS","score":0.42899999022483826},{"id":"https://openalex.org/keywords/alpha-actinin","display_name":"alpha-actinin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vinculin","display_name":"vinculin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/phosphoglycerate-kinase","display_name":"phosphoglycerate kinase","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5338426828384399},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.48311376571655273},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4603211283683777},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4186442196369171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3813345432281494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3584804832935333},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20649340748786926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13342180848121643},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12450659275054932}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3181/0807-rm-220","doi":"https://doi.org/10.3181/0807-rm-220","is_oa":false,"landing_page_url":"https://doi.org/10.3181/0807-rm-220","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:19064946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19064946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental biology and medicine (Maywood, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3229607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4260531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260531","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Biol Med (Maywood)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3229607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4260531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1810225915","display_name":null,"funder_award_id":"L40 HL074825","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G979955607","display_name":"Southwestern Comprehensive Sickle Cell Center","funder_award_id":"U54HL070588","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1574813722","https://openalex.org/W1597151660","https://openalex.org/W1598569053","https://openalex.org/W1639658090","https://openalex.org/W1672565987","https://openalex.org/W1673084462","https://openalex.org/W1887623574","https://openalex.org/W1894221406","https://openalex.org/W1922086062","https://openalex.org/W1971741577","https://openalex.org/W1979032722","https://openalex.org/W1980814594","https://openalex.org/W1984789764","https://openalex.org/W1990814489","https://openalex.org/W1999853225","https://openalex.org/W2010860495","https://openalex.org/W2019483738","https://openalex.org/W2026465178","https://openalex.org/W2032423016","https://openalex.org/W2046299714","https://openalex.org/W2050065017","https://openalex.org/W2059572899","https://openalex.org/W2077173512","https://openalex.org/W2079139546","https://openalex.org/W2083399493","https://openalex.org/W2085961346","https://openalex.org/W2086389810","https://openalex.org/W2087255034","https://openalex.org/W2090013289","https://openalex.org/W2093710478","https://openalex.org/W2097605343","https://openalex.org/W2098143583","https://openalex.org/W2105058587","https://openalex.org/W2133199783","https://openalex.org/W2149877551","https://openalex.org/W2153164765","https://openalex.org/W2165248012","https://openalex.org/W2166281746","https://openalex.org/W2274443207","https://openalex.org/W2322074970","https://openalex.org/W2334263927","https://openalex.org/W3113247834","https://openalex.org/W4236219361","https://openalex.org/W4293765499"],"related_works":["https://openalex.org/W2048820411","https://openalex.org/W7045395013","https://openalex.org/W1922086062","https://openalex.org/W2587956084","https://openalex.org/W4389220258","https://openalex.org/W2736371781","https://openalex.org/W2065655766","https://openalex.org/W2044183384","https://openalex.org/W7134191955","https://openalex.org/W2022861016"],"abstract_inverted_index":{"Using":[0],"two-dimensional":[1],"difference":[2],"gel":[3],"electrophoresis":[4],"(2D":[5],"DIGE)":[6],"we":[7],"have":[8,44],"analyzed":[9],"monocytes":[10],"derived":[11],"from":[12,133],"10":[13],"sickle":[14],"cell":[15],"disease":[16],"patients":[17],"(5":[18],"males":[19],"and":[20,35,70,76,84,115,137,141,146,159],"5":[21],"females":[22],"ages":[23],"12-18)":[24],"to":[25,65,129],"generate":[26],"hypotheses":[27],"regarding":[28],"signature":[29],"proteins":[30,43,63],"that":[31,98],"appear":[32],"most":[33,60,100],"positively":[34,101],"negatively":[36,61],"correlated":[37,62,102],"with":[38,103],"vasoocclusive":[39,161],"event":[40,162],"rate.":[41],"Signature":[42],"been":[45],"identified":[46,151],"by":[47],"tandem":[48],"mass":[49],"spectrometry.":[50],"Based":[51],"on":[52],"the":[53,59,73,92,107,134,138],"limited":[54],"number":[55],"of":[56],"samples":[57,132],"analyzed,":[58],"related":[64],"crises":[66],"rate":[67,105],"were":[68,99,110,149],"transketolase":[69],"coronin":[71],"in":[72,91,106],"membrane":[74],"fraction":[75,109],"heat":[77],"shock":[78],"70":[79],"kDa":[80],"protein":[81,96,114],"cognate":[82],"4,":[83],"adenylate":[85],"kinase":[86,148],"isoenzyme":[87],"2,":[88],"mitochondrial":[89],"found":[90],"cytosolic":[93,142],"fraction.":[94],"The":[95],"spots":[97],"crisis":[104],"cytoplasmic":[108],"far":[111],"upstream":[112],"element-binding":[113],"Alpha":[116,120],"actinin":[117,121],"1":[118],"or":[119],"4.":[122],"Utilizing":[123],"StepSIM":[124],"analysis,":[125],"vinculin":[126],"was":[127],"able":[128],"classify":[130],"all":[131],"combined":[135],"set":[136],"membrane-only":[139],"set,":[140],"leukotriene":[143],"A-4":[144],"hydrolase":[145],"phosphoglycerate":[147],"also":[150],"as":[152],"important":[153],"indicators":[154],"for":[155],"differentiating":[156],"between":[157],"low":[158],"high":[160],"rates.":[163]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}