{"id":"https://openalex.org/W2004755388","doi":"https://doi.org/10.7164/antibiotics.42.1722","title":"Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.","display_name":"Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2004755388","doi":"https://doi.org/10.7164/antibiotics.42.1722","mag":"2004755388","pmid":"https://pubmed.ncbi.nlm.nih.gov/2584153"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.42.1722","doi":"https://doi.org/10.7164/antibiotics.42.1722","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.42.1722","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/42/11/42_11_1722/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/42/11/42_11_1722/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111490450","display_name":"HARUO TANAKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HARUO TANAKA","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan","School of Pharmaceutical Sciences, Kitasato University","The Kitasato Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"The Kitasato Institute","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108392399","display_name":"Takatoshi Kawakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKATOSHI KAWAKAMI","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University","The Kitasato Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"The Kitasato Institute","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110001995","display_name":"Zm-Bo YANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zm-Bo YANG","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University","The Kitasato Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"The Kitasato Institute","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102399037","display_name":"Kanki Komiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KANKI KOMIYAMA","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University","The Kitasato Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"The Kitasato Institute","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045164227","display_name":"Satoshi \u014cmura","orcid":"https://orcid.org/0000-0002-9187-2044","observed_orcids":["https://orcid.org/0000-0002-9187-2044"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SATOSHI OMURA","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University","The Kitasato Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"The Kitasato Institute","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.3868,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.55542108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"42","issue":"11","first_page":"1722","last_page":"1724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-deaminase-inhibitor","display_name":"adenosine deaminase inhibitor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/adenosine-analogues","display_name":"adenosine analogues","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/deoxycoformycin","display_name":"deoxycoformycin","score":0.800000011920929},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.6759999990463257},{"id":"https://openalex.org/keywords/deoxyadenosine","display_name":"deoxyadenosine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nucleoside-metabolism","display_name":"nucleoside metabolism","score":0.5320000052452087},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.743900716304779},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7098771929740906},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.6683963537216187},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6551367044448853},{"id":"https://openalex.org/C2909627636","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine Deaminase Inhibitor","level":4,"score":0.6232891082763672},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5750865936279297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5530630946159363},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4472995102405548},{"id":"https://openalex.org/C165912504","wikidata":"https://www.wikidata.org/wiki/Q4652703","display_name":"AMP deaminase","level":4,"score":0.4204332232475281},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3836570978164673},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32145750522613525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24064543843269348},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0568467378616333}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009700","descriptor_name":"Nucleoside Deaminases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058892","descriptor_name":"Adenosine Deaminase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.42.1722","doi":"https://doi.org/10.7164/antibiotics.42.1722","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.42.1722","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/42/11/42_11_1722/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:2584153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2584153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.42.1722","doi":"https://doi.org/10.7164/antibiotics.42.1722","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.42.1722","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/42/11/42_11_1722/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004755388.pdf","grobid_xml":"https://content.openalex.org/works/W2004755388.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1563942667","https://openalex.org/W1603021521","https://openalex.org/W1963740841","https://openalex.org/W1968395334","https://openalex.org/W1970586406","https://openalex.org/W1983474816","https://openalex.org/W1993823726","https://openalex.org/W2050696025","https://openalex.org/W2072326198","https://openalex.org/W2138157382","https://openalex.org/W3183696909"],"related_works":["https://openalex.org/W2063052100","https://openalex.org/W2028852890","https://openalex.org/W2613349323","https://openalex.org/W1972898761","https://openalex.org/W1666450573","https://openalex.org/W2397068309","https://openalex.org/W2077215096","https://openalex.org/W2434498743","https://openalex.org/W7035834463","https://openalex.org/W2027278083"],"abstract_inverted_index":{"The":[0],"enzyme":[1],"adenosine":[2,25,56,72],"deaminase":[3],"(ADA)":[4],"(adenosine":[5],"aminohydrolase,":[6],"EC":[7],"3.5.4.4),":[8],"which":[9,28,74],"is":[10,15],"widespread":[11],"in":[12,17,55],"mammalian":[13],"tissue,":[14],"involved":[16],"the":[18,21,68],"regulation":[19],"of":[20,24,32,40,71,79],"intracellular":[22],"levels":[23],"and":[26,36,57,62,64,89],"deoxyadenosine,":[27],"control":[29],"a":[30,77],"number":[31],"important":[33],"physiological":[34],"functions":[35],"serve":[37,75],"as":[38,46,76],"precursors":[39],"nucleic":[41],"acid":[42],"biosynthesis.ADA":[43],"inhibitors":[44],"such":[45],"deoxycoformycin":[47],"are":[48],"considered":[49],"to":[50,66],"be":[51],"responsible":[52],"for":[53],"alterations":[54],"deoxyadenosine":[58],"levels,":[59],"lymphocytic":[60],"growth":[61],"functions,":[63],"also":[65],"enhance":[67],"chemotherapeutic":[69],"effects":[70],"analogs":[73],"substrate":[78],"ADA1\\":[80],"Recently,":[81],"we":[82],"found":[83],"two":[84],"new":[85],"ADAinhibitors,":[86],"adechlorin":[87],"(2'-chloropentostatin)2)":[88],"adecype-":[90]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
