{"id":"https://openalex.org/W2004719822","doi":"https://doi.org/10.1095/biolreprod47.6.1082","title":"Melatonin Decreases Estrogen Receptor Expression in the Medial Preoptic Area of Inbred (LSH/SsLak) Golden Hamsters","display_name":"Melatonin Decreases Estrogen Receptor Expression in the Medial Preoptic Area of Inbred (LSH/SsLak) Golden Hamsters","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2004719822","doi":"https://doi.org/10.1095/biolreprod47.6.1082","mag":"2004719822","pmid":"https://pubmed.ncbi.nlm.nih.gov/1493172"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod47.6.1082","doi":"https://doi.org/10.1095/biolreprod47.6.1082","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod47.6.1082","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029222853","display_name":"Nathaniel O. Lawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel O. Lawson","raw_affiliation_strings":["Department of Anatomy, Tulane University School of Medicine, New Orleans, Louisiana 70112","Departments of Anatomy Tulane University School of Medicine New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Tulane University School of Medicine, New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Departments of Anatomy Tulane University School of Medicine New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040091580","display_name":"Beth E.F. Wee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E.F. Wee","raw_affiliation_strings":["Departments of Psychology, Tulane University School of Medicine New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychology, Tulane University School of Medicine New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016402426","display_name":"David E. Blask","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Blask","raw_affiliation_strings":["The Mary Imogene Bassett Hospital Research Institute, Cooperstown, New York 13326\u20131394"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Imogene Bassett Hospital Research Institute, Cooperstown, New York 13326\u20131394","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076689394","display_name":"Carl G. Castles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl G. Castles","raw_affiliation_strings":["Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068893171","display_name":"Louaine L. Spriggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louaine L. Spriggs","raw_affiliation_strings":["Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046305632","display_name":"Steven M. Hill","orcid":"https://orcid.org/0000-0002-5909-692X","observed_orcids":["https://orcid.org/0000-0002-5909-692X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven M. Hill","raw_affiliation_strings":["Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy, Tulane University School of Medicine New Orleans, Louisiana 70112","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046305632"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":1.4704,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76224567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"6","first_page":"1082","last_page":"1090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/medial-preoptic-area","display_name":"medial preoptic area","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/steroid-feedback","display_name":"steroid feedback","score":0.7269999980926514},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.7210000157356262},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.968999981880188},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8777700662612915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7070727348327637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6947016716003418},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.6631357073783875},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.5601783990859985},{"id":"https://openalex.org/C2776451244","wikidata":"https://www.wikidata.org/wiki/Q7240592","display_name":"Preoptic area","level":3,"score":0.4634622633457184},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2132968306541443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod47.6.1082","doi":"https://doi.org/10.1095/biolreprod47.6.1082","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod47.6.1082","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:1493172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1493172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W37894365","https://openalex.org/W166413087","https://openalex.org/W1495842154","https://openalex.org/W1966238775","https://openalex.org/W1967581397","https://openalex.org/W1970061594","https://openalex.org/W1971150954","https://openalex.org/W1972038183","https://openalex.org/W1976495127","https://openalex.org/W1979262770","https://openalex.org/W1981378049","https://openalex.org/W1985434356","https://openalex.org/W2001630174","https://openalex.org/W2007903811","https://openalex.org/W2016988090","https://openalex.org/W2027061276","https://openalex.org/W2027294122","https://openalex.org/W2032258349","https://openalex.org/W2038491937","https://openalex.org/W2047344313","https://openalex.org/W2048388999","https://openalex.org/W2049006873","https://openalex.org/W2050016390","https://openalex.org/W2057451219","https://openalex.org/W2060627150","https://openalex.org/W2060647583","https://openalex.org/W2064023890","https://openalex.org/W2080914907","https://openalex.org/W2084779018","https://openalex.org/W2092047079","https://openalex.org/W2094654195","https://openalex.org/W2100006588","https://openalex.org/W2111481290","https://openalex.org/W2120234752","https://openalex.org/W2123467207","https://openalex.org/W2150659959","https://openalex.org/W2167925490","https://openalex.org/W2951611509"],"related_works":["https://openalex.org/W2035308152","https://openalex.org/W1966647540","https://openalex.org/W2156647523","https://openalex.org/W2046879085","https://openalex.org/W2129792917","https://openalex.org/W2080914907","https://openalex.org/W2046524420","https://openalex.org/W2006025077","https://openalex.org/W2058182208","https://openalex.org/W1979256941"],"abstract_inverted_index":{"Daily":[0],"late":[1],"afternoon":[2],"injections":[3],"of":[4,15,26,49,63,69,82,91,103,120,131,149],"melatonin":[5,50,74,121,150,156],"(25":[6],"micrograms/day":[7],"s.c.)":[8],"were":[9,124],"found":[10],"to":[11,40,116],"reduce":[12],"the":[13,22,36,41,47,56,59,70,87,101,118,128],"number":[14],"cells":[16],"expressing":[17],"estrogen":[18,43,52,83,104,166],"receptor":[19,53,105,167],"immunoreactivity":[20,106],"in":[21,55,80,86,100,127,141,162,169],"medial":[23,60,88,170],"preoptic":[24,61,89,171],"area":[25,90,172],"ovariectomized":[27,64,92],"inbred":[28],"(LSH/SsLak)":[29],"golden":[30],"hamsters.":[31,67,94],"Employing":[32],"immunocytochemical":[33],"analysis":[34],"with":[35],"H222":[37],"monoclonal":[38],"antibody":[39],"human":[42],"receptor,":[44],"we":[45],"examined":[46],"effects":[48,161],"on":[51],"expression":[54],"hypothalamus,":[57],"particularly":[58],"area,":[62],"virgin":[65],"female":[66,93,113],"Analysis":[68],"results":[71,153],"showed":[72],"that":[73,155],"administration":[75],"induced":[76],"a":[77],"50-70%":[78],"decrease":[79,99],"numbers":[81],"receptor-immunoreactive":[84],"neurons":[85],"Furthermore,":[95],"an":[96],"overall":[97],"qualitative":[98],"intensity":[102],"was":[107],"observed.":[108],"In":[109],"intact":[110],"regularly":[111],"cycling":[112],"hamsters":[114,163],"used":[115],"monitor":[117],"efficacy":[119],"treatment,":[122],"there":[123],"significant":[125],"reductions":[126],"serum":[129],"levels":[130,168],"FSH,":[132],"LH,":[133],"and":[134,140,143],"prolactin":[135],"as":[136],"measured":[137],"by":[138,164],"radioimmunoassay":[139],"uterine":[142],"pituitary":[144],"weights":[145],"after":[146],"8":[147],"wk":[148],"treatment.":[151],"These":[152],"suggest":[154],"may":[157],"exert":[158],"its":[159],"anti-reproductive":[160],"modulating":[165],"neurons,":[173],"thus":[174],"influencing":[175],"steroid":[176],"feedback":[177],"mechanisms.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
