{"id":"https://openalex.org/W2004687421","doi":"https://doi.org/10.1200/jco.2003.02.137","title":"High Prevalence of Premalignant Lesions in Prophylactically Removed Breasts From Women at Hereditary Risk for Breast Cancer","display_name":"High Prevalence of Premalignant Lesions in Prophylactically Removed Breasts From Women at Hereditary Risk for Breast Cancer","publication_year":2002,"publication_date":"2002-12-28","ids":{"openalex":"https://openalex.org/W2004687421","doi":"https://doi.org/10.1200/jco.2003.02.137","mag":"2004687421","pmid":"https://pubmed.ncbi.nlm.nih.gov/12506168"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2003.02.137","doi":"https://doi.org/10.1200/jco.2003.02.137","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2003.02.137","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2066/144389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014697573","display_name":"Nicoline Hoogerbrugge","orcid":"https://orcid.org/0000-0003-2393-8141","observed_orcids":["https://orcid.org/0000-0003-2393-8141"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N. Hoogerbrugge","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006119564","display_name":"Peter Bult","orcid":"https://orcid.org/0000-0001-6427-9889","observed_orcids":["https://orcid.org/0000-0001-6427-9889"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Bult","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041572085","display_name":"Louise M. de Widt-Levert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L.M. de Widt-Levert","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108519251","display_name":"Louk V.A.M. Beex","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L.V. Beex","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045763456","display_name":"Lambertus A.L.M. Kiemeney","orcid":"https://orcid.org/0000-0002-2368-1326","observed_orcids":["https://orcid.org/0000-0002-2368-1326"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L.A. Kiemeney","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024569299","display_name":"Marjolijn J. L. Ligtenberg","orcid":"https://orcid.org/0000-0003-1290-1474","observed_orcids":["https://orcid.org/0000-0003-1290-1474"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.J.L. Ligtenberg","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030950283","display_name":"LFAG Massuger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L.F. Massuger","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080708656","display_name":"Carla Boetes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. Boetes","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015314389","display_name":"Peggy Manders","orcid":"https://orcid.org/0000-0002-7066-6946","observed_orcids":["https://orcid.org/0000-0002-7066-6946"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Manders","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030485933","display_name":"Han G. Brunner","orcid":"https://orcid.org/0000-0001-9274-8865","observed_orcids":["https://orcid.org/0000-0001-9274-8865"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.G. Brunner","raw_affiliation_strings":["From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hereditary Cancer Clinic, Departments of Human Genetics, Medical Oncology, Pathology, Surgery, Epidemiology and Biostatistics, Gynecology, and Radiology, University Medical Center Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":null,"apc_paid":null,"fwci":4.7629,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95745335,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"41","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/risk-reducing-mastectomy","display_name":"prophylactic mastectomy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/premalignant-breast-lesions","display_name":"premalignant breast lesions","score":0.9539999961853027},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/brca2-mutation","display_name":"BRCA2 mutation","score":1.0},{"id":"https://openalex.org/keywords/atypical-lobular-hyperplasia","display_name":"atypical lobular hyperplasia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atypical-ductal-hyperplasia","display_name":"atypical ductal hyperplasia","score":1.0},{"id":"https://openalex.org/keywords/lobular-carcinoma-in-situ","display_name":"lobular carcinoma in situ","score":0.972000002861023},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":1.0},{"id":"https://openalex.org/keywords/oophorectomy","display_name":"oophorectomy","score":0.800000011920929},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.652999997138977},{"id":"https://openalex.org/keywords/breast-cancer-surveillance","display_name":"breast cancer surveillance","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9122859835624695},{"id":"https://openalex.org/C2910039337","wikidata":"https://www.wikidata.org/wiki/Q16394661","display_name":"Prophylactic Mastectomy","level":5,"score":0.736760675907135},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7138794660568237},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.6718680262565613},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.578436553478241},{"id":"https://openalex.org/C2779296616","wikidata":"https://www.wikidata.org/wiki/Q6663895","display_name":"Lobular carcinoma","level":5,"score":0.5232633352279663},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.5095008015632629},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4594785273075104},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4252975285053253},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38391759991645813},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37946417927742004},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3684793710708618},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3365124464035034}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017677","descriptor_name":"Age Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.2003.02.137","doi":"https://doi.org/10.1200/jco.2003.02.137","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2003.02.137","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:12506168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12506168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/144389","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/144389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/144389","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/144389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, 21, 41 - 5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/144389","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/144389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, 21, 41 - 5","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W121553317","https://openalex.org/W168637747","https://openalex.org/W1531019181","https://openalex.org/W1605263017","https://openalex.org/W1860535085","https://openalex.org/W1919554514","https://openalex.org/W1966928100","https://openalex.org/W1975999486","https://openalex.org/W1980540383","https://openalex.org/W1983163375","https://openalex.org/W1991555835","https://openalex.org/W2004132765","https://openalex.org/W2018396463","https://openalex.org/W2038976451","https://openalex.org/W2046809735","https://openalex.org/W2055403282","https://openalex.org/W2059127404","https://openalex.org/W2060589505","https://openalex.org/W2062249241","https://openalex.org/W2070400746","https://openalex.org/W2071762482","https://openalex.org/W2073611256","https://openalex.org/W2086199722","https://openalex.org/W2094666421","https://openalex.org/W2101699473","https://openalex.org/W2103970959","https://openalex.org/W2104836626","https://openalex.org/W2142491513","https://openalex.org/W2144624092","https://openalex.org/W2145703637","https://openalex.org/W2312752082","https://openalex.org/W2328561181","https://openalex.org/W2398851242","https://openalex.org/W2409321736","https://openalex.org/W2526936954","https://openalex.org/W2886860701","https://openalex.org/W4243864489","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2004205427","https://openalex.org/W1973444055","https://openalex.org/W2008771039","https://openalex.org/W4388915006","https://openalex.org/W2061226184","https://openalex.org/W2177776521","https://openalex.org/W2009671923","https://openalex.org/W2398851242","https://openalex.org/W249588909","https://openalex.org/W2061827632"],"abstract_inverted_index":{"PURPOSE:":[0],"Women":[1],"with":[2,75,108,169],"a":[3,58,90],"hereditary":[4,227],"predisposition":[5],"for":[6],"breast":[7,17,62,73,79,122,228],"cancer":[8,229],"have":[9],"an":[10],"extremely":[11,68],"high":[12,69,224],"risk":[13,71,225],"of":[14,31,38,50,61,72,89,104,111,120,130,138,173,190,226,238],"developing":[15],"invasive":[16,161],"carcinoma,":[18],"and":[19,101,114,123,155,207],"many":[20],"women":[21,66,222],"consider":[22],"prophylactic":[23,32,51,84,212],"mastectomy":[24,33,43,85,213],"to":[25,196,208],"avoid":[26],"this":[27],"risk.":[28],"The":[29,188],"use":[30],"is":[34],"still":[35],"debated.":[36],"Identification":[37],"frequent":[39],"premalignant":[40],"lesions":[41,113,141,175,192],"in":[42,166],"specimens":[44,63,96],"would":[45],"support":[46],"the":[47,121,124,131,186,236],"preventive":[48],"concept":[49],"mastectomy.":[52,187],"PATIENTS":[53],"AND":[54],"METHODS:":[55],"We":[56],"performed":[57,184],"prospective":[59],"study":[60],"from":[64,117],"67":[65],"at":[67,178,223],"genetic":[70],"cancer,":[74,80],"or":[76,92,134,180],"without":[77],"previous":[78],"who":[81],"were":[82,87,97,142,183],"undergoing":[83],"(66%":[86],"carriers":[88],"BRCA1":[91],"BRCA2":[93],"mutation).":[94],"Breast":[95],"studied":[98],"by":[99],"radiographic":[100],"macroscopic":[102],"examination":[103],"5-mm":[105],"tissue":[106],"slices,":[107],"subsequent":[109],"histology":[110],"suspicious":[112],"random":[115],"samples":[116],"each":[118],"quadrant":[119],"nipple":[125],"area.":[126],"RESULTS:":[127],"In":[128],"57%":[129],"women,":[132],"one":[133,167],"more":[135],"different":[136],"types":[137],"high-risk":[139,191,231,246],"histopathologic":[140,232,247],"present:":[143],"37%":[144],"atypical":[145,149],"lobular":[146,153],"hyperplasia,":[147,151],"39%":[148],"ductal":[150,157,162,170],"25%":[152],"carcinoma-in-situ,":[154],"15%":[156],"carcinoma-in-situ.":[158,171],"A":[159],"4-mm":[160],"carcinoma":[163],"was":[164,176,193],"found":[165],"woman":[168],"None":[172],"these":[174],"detected":[177],"palpation":[179],"mammography,":[181],"which":[182],"before":[185,211],"presence":[189],"independently":[194],"related":[195],"age":[197,237],"older":[198],"than":[199],"40":[200,239],"years":[201],"(odds":[202,214],"ratio,":[203,215],"6.6;":[204],"P":[205,217],"=.01)":[206],"bilateral":[209],"oophorectomy":[210],"0.2;":[216],"=":[218],"0.02).":[219],"CONCLUSION:":[220],"Many":[221],"develop":[230],"lesions,":[233],"especially":[234],"after":[235],"years.":[240],"Surveillance":[241],"does":[242],"not":[243],"detect":[244],"such":[245],"lesions.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}