{"id":"https://openalex.org/W2004679528","doi":"https://doi.org/10.3892/ol.2011.512","title":"The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis","display_name":"The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis","publication_year":2011,"publication_date":"2011-12-05","ids":{"openalex":"https://openalex.org/W2004679528","doi":"https://doi.org/10.3892/ol.2011.512","mag":"2004679528","pmid":"https://pubmed.ncbi.nlm.nih.gov/22740973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3362408"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2011.512","doi":"https://doi.org/10.3892/ol.2011.512","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2011.512","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2011.512/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/ol.2011.512/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108383399","display_name":"Ya-Min Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"YA-MIN CHENG","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan","Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073351431","display_name":"Cheng-Yang Chou","orcid":"https://orcid.org/0000-0003-4244-1421","observed_orcids":["https://orcid.org/0000-0003-4244-1421"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"CHENG-YANG CHOU","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064710817","display_name":"Yi\u2010Chiang Hsu","orcid":"https://orcid.org/0000-0002-6256-9521","observed_orcids":["https://orcid.org/0000-0002-6256-9521"]},"institutions":[{"id":"https://openalex.org/I80327900","display_name":"Chang Jung Christian University","ror":"https://ror.org/02s3d7j94","country_code":"TW","type":"education","lineage":["https://openalex.org/I80327900"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"YI-CHIANG HSU","raw_affiliation_strings":["Graduate Institute of Medical Science and Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Science and Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I80327900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067193889","display_name":"Ming\u2010Jenn Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"MING-JENN CHEN","raw_affiliation_strings":["Division of Traumatology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Traumatology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111751759","display_name":"Lih-Yuh C. Wing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"LIH-YUH C. WING","raw_affiliation_strings":["Department of Physiology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9192,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.83182974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"667","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9539999961853027},{"id":"https://openalex.org/keywords/e6-and-e7-oncoproteins","display_name":"HPV E6 and E7 oncoproteins","score":0.9120000004768372},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fgf4","display_name":"FGF4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":1.0},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.8741002678871155},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.7732508182525635},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7034533619880676},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6218883395195007},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6105881333351135},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5221439003944397},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5131307244300842},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4980738162994385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4482708275318146},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.4418070614337921},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4239580035209656},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41427600383758545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3699350357055664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3302842676639557},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2270362675189972},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2034531533718109},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09149080514907837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.049142420291900635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/ol.2011.512","doi":"https://doi.org/10.3892/ol.2011.512","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2011.512","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2011.512/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2387111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3362408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22740973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22740973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3362408","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3362408/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ol.2011.512","doi":"https://doi.org/10.3892/ol.2011.512","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2011.512","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2011.512/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322933","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17"},{"id":"https://openalex.org/F4320324663","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004679528.pdf","grobid_xml":"https://content.openalex.org/works/W2004679528.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1957970196","https://openalex.org/W1980192704","https://openalex.org/W1992774812","https://openalex.org/W2005117549","https://openalex.org/W2005913476","https://openalex.org/W2006087233","https://openalex.org/W2012769611","https://openalex.org/W2014331589","https://openalex.org/W2016713114","https://openalex.org/W2018740895","https://openalex.org/W2020566416","https://openalex.org/W2031799318","https://openalex.org/W2040499060","https://openalex.org/W2052581758","https://openalex.org/W2057038864","https://openalex.org/W2058928888","https://openalex.org/W2063841790","https://openalex.org/W2065289608","https://openalex.org/W2086748020","https://openalex.org/W2094541918","https://openalex.org/W2097220529","https://openalex.org/W2103547981","https://openalex.org/W2139850359","https://openalex.org/W2153685871","https://openalex.org/W2156793931","https://openalex.org/W2314920404","https://openalex.org/W2416217862","https://openalex.org/W6716588592"],"related_works":["https://openalex.org/W602102388","https://openalex.org/W2001961423","https://openalex.org/W1968749298","https://openalex.org/W2071781773","https://openalex.org/W7097248375","https://openalex.org/W1991247317","https://openalex.org/W2103852160","https://openalex.org/W2047622816","https://openalex.org/W1508378957","https://openalex.org/W4200601636"],"abstract_inverted_index":{"Cervical":[0],"cancer":[1,118,151],"is":[2,153],"the":[3,13,16,44,62,84,91,108,158,163],"most":[4],"common":[5],"malignancy":[6],"in":[7,28,97,116,148],"females":[8],"worldwide.":[9],"This":[10],"study":[11],"investigated":[12,43],"prevalence":[14],"of":[15,19,64,86,93,111,126,142,165],"E6/E7":[17,101,132,144],"oncoproteins":[18],"human":[20,149],"papillomavirus":[21],"(HPV)":[22],"type":[23],"16,":[24],"which":[25],"are":[26],"important":[27],"fibroblast":[29],"growth":[30,77],"factor":[31],"(FGF)":[32],"2-":[33],"and":[34,39,54,58,70,78,88,90,133,136,145,169],"4-induced":[35],"epithelial-mesenchymal":[36,167],"transition":[37,168],"(EMT)":[38],"cervical":[40,117,150,166],"tumorigenesis.":[41,170],"We":[42],"functional":[45,128],"interaction":[46,129],"between":[47,130],"HPV16":[48,100,131],"E6/E7-transfected":[49],"Cx":[50],"cells":[51,119,152],"(CxWJ":[52,120],"cells)":[53],"treatment":[55],"with":[56,162],"FGF2":[57,112],"4,":[59,137],"according":[60],"to":[61,155],"expression":[63,96],"\u03b1-smooth":[65],"muscle":[66],"actin":[67],"(\u03b1-SMA),":[68],"vimentin":[69,89],"E-cadherin":[71,94],"protein":[72,95],"as":[73,75],"well":[74],"cell":[76],"invasive":[79,109],"ability.":[80],"The":[81],"results":[82],"showed":[83],"upregulation":[85],"\u03b1-SMA":[87],"downregulation":[92],"CxWJ":[98],"cells.":[99],"infection":[102],"partially":[103],"repressed":[104],"proliferation,":[105],"but":[106],"not":[107],"ability":[110],"or":[113],"FGF4":[114],"stimulation":[115,141],"cells).":[121],"These":[122],"data":[123],"provide":[124],"evidence":[125],"a":[127],"FGFs":[134,146],"2":[135],"suggesting":[138],"that":[139],"cooperative":[140],"HPV":[143],"activated":[147],"required":[154],"completely":[156],"overcome":[157],"oncogenic":[159],"function":[160],"associated":[161],"development":[164]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
