{"id":"https://openalex.org/W2004677075","doi":"https://doi.org/10.1161/circresaha.111.300496","title":"Oxidative Stress and Sarcomeric Proteins","display_name":"Oxidative Stress and Sarcomeric Proteins","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2004677075","doi":"https://doi.org/10.1161/circresaha.111.300496","mag":"2004677075","pmid":"https://pubmed.ncbi.nlm.nih.gov/23329794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595003"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.111.300496","doi":"https://doi.org/10.1161/circresaha.111.300496","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.111.300496","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.300496","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.300496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035111317","display_name":"Susan F. Steinberg","orcid":"https://orcid.org/0000-0002-2927-8570","observed_orcids":["https://orcid.org/0000-0002-2927-8570"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan F. Steinberg","raw_affiliation_strings":["From the Department of Pharmacology, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035111317"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":1.637,"has_fulltext":true,"cited_by_count":197,"citation_normalized_percentile":{"value":0.84972988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"112","issue":"2","first_page":"393","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/sarcomeric-proteins","display_name":"sarcomeric proteins","score":0.9490000009536743},{"id":"https://openalex.org/keywords/myofilament-proteins","display_name":"myofilament proteins","score":0.8510000109672546},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.5540000200271606},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7850000262260437},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ischemia-reperfusion","display_name":"ischemia-reperfusion","score":0.9079999923706055},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hypertensive-heart-disease","display_name":"hypertensive heart disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.8871220350265503},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7399576902389526},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6985779404640198},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5898319482803345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5513932704925537},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5269801616668701},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.5144296288490295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4384118318557739},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.426975280046463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3956993520259857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.324850469827652},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.27635490894317627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2146502435207367},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.20692116022109985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20477455854415894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16408801078796387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circresaha.111.300496","doi":"https://doi.org/10.1161/circresaha.111.300496","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.111.300496","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.300496","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:23329794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23329794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2878879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3595003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.111.300496","doi":"https://doi.org/10.1161/circresaha.111.300496","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.111.300496","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.300496","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2833558716","display_name":"PKD Isoforms in Heart","funder_award_id":"R01HL112388","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7247078319","display_name":"Protein kinase C-delta actions in cardiomyocytes","funder_award_id":"R01HL077860","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004677075.pdf","grobid_xml":"https://content.openalex.org/works/W2004677075.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W1233659682","https://openalex.org/W1488599557","https://openalex.org/W1518614162","https://openalex.org/W1538762668","https://openalex.org/W1598693902","https://openalex.org/W1964876495","https://openalex.org/W1967582474","https://openalex.org/W1974893888","https://openalex.org/W1975536445","https://openalex.org/W1979551416","https://openalex.org/W1982748977","https://openalex.org/W1982988117","https://openalex.org/W1989527553","https://openalex.org/W1991981480","https://openalex.org/W1999625103","https://openalex.org/W2001544929","https://openalex.org/W2002758115","https://openalex.org/W2005591501","https://openalex.org/W2006659891","https://openalex.org/W2006723186","https://openalex.org/W2013969219","https://openalex.org/W2014618422","https://openalex.org/W2016568695","https://openalex.org/W2017068027","https://openalex.org/W2017565733","https://openalex.org/W2017847073","https://openalex.org/W2017851912","https://openalex.org/W2021861995","https://openalex.org/W2023645080","https://openalex.org/W2024605566","https://openalex.org/W2028096273","https://openalex.org/W2028117464","https://openalex.org/W2031196559","https://openalex.org/W2033895902","https://openalex.org/W2036556195","https://openalex.org/W2040739900","https://openalex.org/W2044909153","https://openalex.org/W2045187262","https://openalex.org/W2046230753","https://openalex.org/W2047024172","https://openalex.org/W2049723177","https://openalex.org/W2050206397","https://openalex.org/W2050274413","https://openalex.org/W2050313711","https://openalex.org/W2054059469","https://openalex.org/W2055661475","https://openalex.org/W2060720376","https://openalex.org/W2065823396","https://openalex.org/W2065835031","https://openalex.org/W2069292608","https://openalex.org/W2069532611","https://openalex.org/W2071187274","https://openalex.org/W2071468228","https://openalex.org/W2072268646","https://openalex.org/W2076729427","https://openalex.org/W2080115585","https://openalex.org/W2085253569","https://openalex.org/W2087063770","https://openalex.org/W2087986257","https://openalex.org/W2088065483","https://openalex.org/W2089013981","https://openalex.org/W2091583229","https://openalex.org/W2091886434","https://openalex.org/W2095467143","https://openalex.org/W2096124234","https://openalex.org/W2098445463","https://openalex.org/W2098587086","https://openalex.org/W2099159245","https://openalex.org/W2099257249","https://openalex.org/W2100659208","https://openalex.org/W2102898181","https://openalex.org/W2106762735","https://openalex.org/W2109694057","https://openalex.org/W2111446613","https://openalex.org/W2112964556","https://openalex.org/W2114260140","https://openalex.org/W2117327744","https://openalex.org/W2121998234","https://openalex.org/W2125960721","https://openalex.org/W2126910504","https://openalex.org/W2132932675","https://openalex.org/W2135289666","https://openalex.org/W2135624975","https://openalex.org/W2138728266","https://openalex.org/W2139906029","https://openalex.org/W2142544974","https://openalex.org/W2142986295","https://openalex.org/W2145309926","https://openalex.org/W2147553897","https://openalex.org/W2150832969","https://openalex.org/W2152887520","https://openalex.org/W2153177273","https://openalex.org/W2154554241","https://openalex.org/W2156599331","https://openalex.org/W2164535496","https://openalex.org/W2165440393","https://openalex.org/W2167400743","https://openalex.org/W2169582078","https://openalex.org/W2170295209","https://openalex.org/W2172057874","https://openalex.org/W4320803702"],"related_works":["https://openalex.org/W1978042419","https://openalex.org/W2888760579","https://openalex.org/W2034980975","https://openalex.org/W1975186819","https://openalex.org/W55719727","https://openalex.org/W2520240595","https://openalex.org/W1989324891","https://openalex.org/W2027946367","https://openalex.org/W2147653980","https://openalex.org/W6981249157"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"accompanies":[2],"a":[3],"wide":[4],"spectrum":[5],"of":[6,37,42,53,60,71,77,83,101,108,132],"clinically":[7],"important":[8],"cardiac":[9,133],"disorders,":[10],"including":[11],"ischemia/reperfusion,":[12],"diabetes":[13],"mellitus,":[14],"and":[15,33,50,80,118],"hypertensive":[16],"heart":[17,54],"disease.":[18],"Although":[19],"reactive":[20],"oxygen":[21],"species":[22],"(ROS)":[23],"can":[24],"activate":[25],"signaling":[26,116],"pathways":[27],"that":[28,45,125],"contribute":[29],"to":[30],"ischemic":[31],"preconditioning":[32],"cardioprotection,":[34],"high":[35],"levels":[36],"ROS":[38],"induce":[39],"structural":[40],"modifications":[41,86,100,107],"the":[43,51,57,61,69,72,75,81,91,130],"sarcomere":[44],"impact":[46],"on":[47,87,96],"pump":[48],"function":[49],"pathogenesis":[52],"failure.":[55],"However,":[56],"precise":[58],"nature":[59],"redox-dependent":[62],"change":[63],"in":[64,129],"contractility":[65],"is":[66],"determined":[67],"by":[68,114,122],"source/identity":[70],"oxidant":[73],"species,":[74],"level":[76],"oxidative":[78,106],"stress,":[79],"chemistry/position":[82],"oxidant-induced":[84],"posttranslational":[85,99],"individual":[88],"proteins":[89,103],"within":[90],"sarcomere.":[92],"This":[93],"review":[94],"focuses":[95],"various":[97],"ROS-induced":[98],"myofilament":[102,109,111,119],"(including":[104],"direct":[105],"proteins,":[110],"protein":[112,120],"phosphorylation":[113],"ROS-activated":[115,123],"enzymes,":[117],"cleavage":[121],"proteases)":[124],"have":[126],"been":[127],"implicated":[128],"control":[131],"contractility.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
