{"id":"https://openalex.org/W2004673922","doi":"https://doi.org/10.1136/gut.32.9.1082","title":"Transplantation of a donor liver with haemochromatosis: evidence against an inherited intrahepatic defect.","display_name":"Transplantation of a donor liver with haemochromatosis: evidence against an inherited intrahepatic defect.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2004673922","doi":"https://doi.org/10.1136/gut.32.9.1082","mag":"2004673922","pmid":"https://pubmed.ncbi.nlm.nih.gov/1916497","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1379056"},"language":"en","primary_location":{"id":"doi:10.1136/gut.32.9.1082","doi":"https://doi.org/10.1136/gut.32.9.1082","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.32.9.1082","pdf_url":"https://gut.bmj.com/content/gutjnl/32/9/1082.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/32/9/1082.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067214484","display_name":"Paul C. Adams","orcid":"https://orcid.org/0000-0002-9921-2956","observed_orcids":["https://orcid.org/0000-0002-9921-2956"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P C Adams","raw_affiliation_strings":["Department of Medicine, University Hospital, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110190108","display_name":"Cameron N. Ghent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C N Ghent","raw_affiliation_strings":["Department of Medicine, University Hospital, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000205473","display_name":"David R Grant","orcid":"https://orcid.org/0000-0003-4468-8276","observed_orcids":["https://orcid.org/0000-0003-4468-8276"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D R Grant","raw_affiliation_strings":["Department of Medicine, University Hospital, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108459512","display_name":"J Frei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J V Frei","raw_affiliation_strings":["Department of Medicine, University Hospital, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108415632","display_name":"William J Wall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"W J Wall","raw_affiliation_strings":["Department of Medicine, University Hospital, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":1.2118,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.77993197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"32","issue":"9","first_page":"1082","last_page":"1083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemochromatosis","display_name":"hemochromatosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatic-iron-overload","display_name":"hepatic iron overload","score":0.6710000038146973},{"id":"https://openalex.org/keywords/iron-absorption","display_name":"iron absorption","score":0.7390000224113464},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.7940000295639038},{"id":"https://openalex.org/keywords/acetaminophen-overdose","display_name":"acetaminophen overdose","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-rejection","display_name":"liver rejection","score":0.7929999828338623},{"id":"https://openalex.org/keywords/genetic-disorders","display_name":"genetic disorders","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.675142228603363},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6718817353248596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6639640927314758},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.6516934633255005},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.6473169922828674},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6083127856254578},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5993850827217102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5234935879707336},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.5143216848373413},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35512903332710266},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/gut.32.9.1082","doi":"https://doi.org/10.1136/gut.32.9.1082","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.32.9.1082","pdf_url":"https://gut.bmj.com/content/gutjnl/32/9/1082.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1379056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1379056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:1916497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1916497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/gut.32.9.1082","doi":"https://doi.org/10.1136/gut.32.9.1082","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.32.9.1082","pdf_url":"https://gut.bmj.com/content/gutjnl/32/9/1082.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004673922.pdf","grobid_xml":"https://content.openalex.org/works/W2004673922.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1003906504","https://openalex.org/W1510811131","https://openalex.org/W1556883646","https://openalex.org/W1862553941","https://openalex.org/W2011442905","https://openalex.org/W2034684849","https://openalex.org/W2055628616","https://openalex.org/W2058320976","https://openalex.org/W2163469200","https://openalex.org/W2394791642","https://openalex.org/W2399830561","https://openalex.org/W2433742047","https://openalex.org/W2460147824","https://openalex.org/W2996995245"],"related_works":["https://openalex.org/W1981700383","https://openalex.org/W2062580179","https://openalex.org/W2093974694","https://openalex.org/W1991813163","https://openalex.org/W1988192574","https://openalex.org/W2058771261","https://openalex.org/W2121728164","https://openalex.org/W184150774","https://openalex.org/W4230687739","https://openalex.org/W2806297135"],"abstract_inverted_index":{"An":[0],"iron":[1,33,66,106,110],"loaded":[2],"liver":[3,23,38,59],"from":[4,69],"a":[5,16,27,37],"40":[6],"year":[7,18],"old":[8,19],"man":[9],"with":[10,21],"occult":[11],"haemochromatosis":[12,120],"was":[13,34,94],"transplanted":[14],"into":[15],"19":[17],"woman":[20],"acute":[22],"failure":[24],"secondary":[25],"to":[26,77],"paracetamol":[28],"overdose.":[29],"Increased":[30],"parenchymal":[31],"hepatic":[32,65,105],"found":[35],"in":[36,95,104],"specimen":[39],"at":[40,99],"biopsy":[41],"undertaken":[42],"because":[43],"of":[44,58,119],"mild":[45],"rejection":[46,60],"30":[47,74],"days":[48,91],"after":[49,75,92],"transplantation.":[50],"After":[51],"transplantation":[52],"the":[53,96,108,116],"patient":[54],"had":[55],"two":[56],"episodes":[57],"confirmed":[61],"by":[62],"biopsy.":[63],"The":[64,101],"concentration":[67],"fell":[68],"161":[70],"mumol/g":[71,79],"on":[72,84],"day":[73,85],"transplant":[76],"26.5":[78],"(normal":[80],"less":[81],"than":[82],"40)":[83],"210.":[86],"Iron":[87],"absorption,":[88],"measured":[89],"45":[90],"transplant,":[93],"normal":[97,109],"range":[98],"12.4%.":[100],"rapid":[102],"fall":[103],"and":[107],"absorption":[111],"study":[112],"result":[113],"suggest":[114],"that":[115],"genetic":[117],"defect":[118],"is":[121],"not":[122],"exclusively":[123],"an":[124],"intrahepatic":[125],"defect.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}