{"id":"https://openalex.org/W2004673069","doi":"https://doi.org/10.2478/v10011-007-0049-x","title":"New Markers of Oxidative Damage to Macromolecules","display_name":"New Markers of Oxidative Damage to Macromolecules","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2004673069","doi":"https://doi.org/10.2478/v10011-007-0049-x","mag":"2004673069"},"language":"en","primary_location":{"id":"doi:10.2478/v10011-007-0049-x","doi":"https://doi.org/10.2478/v10011-007-0049-x","is_oa":true,"landing_page_url":"https://doi.org/10.2478/v10011-007-0049-x","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801001C.pdf","source":{"id":"https://openalex.org/S142815329","display_name":"Journal of Medical Biochemistry","issn_l":"1452-8266","issn":["1452-8266","1452-8258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801001C.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108518318","display_name":"Emina \u010colak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Emina \u010colak","raw_affiliation_strings":["Institute of Medical Biochemistry Clinical Center of Serbia Vi{egradska 26 11000 Belgrade, Serbia","Institute of Medical Biochemistry, CCS, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry Clinical Center of Serbia Vi{egradska 26 11000 Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Institute of Medical Biochemistry, CCS, Belgrade, Serbia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108518318"],"corresponding_institution_ids":["https://openalex.org/I4210113171"],"apc_list":{"value":58000,"currency":"RSD","value_usd":null},"apc_paid":null,"fwci":1.417,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.76477684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"1","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.6600000262260437},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6129999756813049},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/dna-oxidation","display_name":"DNA oxidation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/carbonyl-stress","display_name":"carbonyl stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.6499999761581421},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chlorotyrosine","display_name":"chlorotyrosine","score":0.8870000243186951},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8339999914169312},{"id":"https://openalex.org/keywords/isoprostanes","display_name":"isoprostanes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7720000147819519},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.48899999260902405},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.5090000033378601},{"id":"https://openalex.org/keywords/gamma-radiation-damage","display_name":"gamma radiation damage","score":0.35899999737739563},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7872101664543152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7508960962295532},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7011210918426514},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6748738288879395},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.571034848690033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5014266967773438},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5000057220458984},{"id":"https://openalex.org/C60642223","wikidata":"https://www.wikidata.org/wiki/Q1129576","display_name":"Free-radical theory of aging","level":3,"score":0.4232950508594513}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2478/v10011-007-0049-x","doi":"https://doi.org/10.2478/v10011-007-0049-x","is_oa":true,"landing_page_url":"https://doi.org/10.2478/v10011-007-0049-x","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801001C.pdf","source":{"id":"https://openalex.org/S142815329","display_name":"Journal of Medical Biochemistry","issn_l":"1452-8266","issn":["1452-8266","1452-8258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Biochemistry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:40f3709cd0b84c6d9e1f78b836f71608","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/40f3709cd0b84c6d9e1f78b836f71608","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medical Biochemistry, Vol 27, Iss 1, Pp 1-16 (2008)","raw_type":"article"},{"id":"mag:3151775731","doi":null,"is_oa":false,"landing_page_url":"http://www.dmbj.org.rs/jmb/pdf/2008-1/colak.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.2478/v10011-007-0049-x","doi":"https://doi.org/10.2478/v10011-007-0049-x","is_oa":true,"landing_page_url":"https://doi.org/10.2478/v10011-007-0049-x","pdf_url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801001C.pdf","source":{"id":"https://openalex.org/S142815329","display_name":"Journal of Medical Biochemistry","issn_l":"1452-8266","issn":["1452-8266","1452-8258"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004673069.pdf","grobid_xml":"https://content.openalex.org/works/W2004673069.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W122134017","https://openalex.org/W1274506549","https://openalex.org/W1484882395","https://openalex.org/W1489408430","https://openalex.org/W1523474209","https://openalex.org/W1533957206","https://openalex.org/W1541881494","https://openalex.org/W1551488721","https://openalex.org/W1565380190","https://openalex.org/W1572011530","https://openalex.org/W1759706356","https://openalex.org/W1794856894","https://openalex.org/W1912804942","https://openalex.org/W1919879546","https://openalex.org/W1922324982","https://openalex.org/W1940436875","https://openalex.org/W1952120822","https://openalex.org/W1964086052","https://openalex.org/W1966234811","https://openalex.org/W1966603392","https://openalex.org/W1968233853","https://openalex.org/W1968610334","https://openalex.org/W1971424572","https://openalex.org/W1972153352","https://openalex.org/W1972658910","https://openalex.org/W1973432226","https://openalex.org/W1975560094","https://openalex.org/W1976616659","https://openalex.org/W1980405844","https://openalex.org/W1981182593","https://openalex.org/W1982870743","https://openalex.org/W1987003312","https://openalex.org/W1995980300","https://openalex.org/W1996205410","https://openalex.org/W1996726425","https://openalex.org/W1997550706","https://openalex.org/W1999921360","https://openalex.org/W2000567558","https://openalex.org/W2001426234","https://openalex.org/W2004839630","https://openalex.org/W2005877818","https://openalex.org/W2009187135","https://openalex.org/W2011282129","https://openalex.org/W2013592393","https://openalex.org/W2013639399","https://openalex.org/W2014697941","https://openalex.org/W2015090490","https://openalex.org/W2015970562","https://openalex.org/W2018960160","https://openalex.org/W2020888421","https://openalex.org/W2022377100","https://openalex.org/W2022495082","https://openalex.org/W2023419047","https://openalex.org/W2028164957","https://openalex.org/W2029314163","https://openalex.org/W2030135352","https://openalex.org/W2030256346","https://openalex.org/W2033076107","https://openalex.org/W2036806484","https://openalex.org/W2037426867","https://openalex.org/W2037542399","https://openalex.org/W2038097351","https://openalex.org/W2038516205","https://openalex.org/W2040151193","https://openalex.org/W2041553103","https://openalex.org/W2044627978","https://openalex.org/W2046511609","https://openalex.org/W2046875213","https://openalex.org/W2047860278","https://openalex.org/W2048005287","https://openalex.org/W2049126986","https://openalex.org/W2055553130","https://openalex.org/W2056620406","https://openalex.org/W2056802785","https://openalex.org/W2057522312","https://openalex.org/W2063142823","https://openalex.org/W2064000861","https://openalex.org/W2069240139","https://openalex.org/W2075034126","https://openalex.org/W2075081000","https://openalex.org/W2075303826","https://openalex.org/W2081240175","https://openalex.org/W2085917914","https://openalex.org/W2087025400","https://openalex.org/W2088088066","https://openalex.org/W2089590097","https://openalex.org/W2090515271","https://openalex.org/W2091954160","https://openalex.org/W2092279282","https://openalex.org/W2092335156","https://openalex.org/W2094475056","https://openalex.org/W2095014707","https://openalex.org/W2102212941","https://openalex.org/W2104380573","https://openalex.org/W2106033501","https://openalex.org/W2109439103","https://openalex.org/W2113007696","https://openalex.org/W2115978010","https://openalex.org/W2117155507","https://openalex.org/W2118734820","https://openalex.org/W2119914343","https://openalex.org/W2121191392","https://openalex.org/W2126728583","https://openalex.org/W2127136618","https://openalex.org/W2128783891","https://openalex.org/W2129852694","https://openalex.org/W2130892097","https://openalex.org/W2133536720","https://openalex.org/W2134160865","https://openalex.org/W2134724878","https://openalex.org/W2136087740","https://openalex.org/W2138121094","https://openalex.org/W2138560564","https://openalex.org/W2140665078","https://openalex.org/W2144725045","https://openalex.org/W2147929482","https://openalex.org/W2147993424","https://openalex.org/W2153767421","https://openalex.org/W2154788118","https://openalex.org/W2160369264","https://openalex.org/W2161624379","https://openalex.org/W2161888004","https://openalex.org/W2163647109","https://openalex.org/W2164066515","https://openalex.org/W2168621707","https://openalex.org/W2169427980","https://openalex.org/W2175642831","https://openalex.org/W2185276608","https://openalex.org/W2204123985","https://openalex.org/W2295911240","https://openalex.org/W2315512556","https://openalex.org/W2325222315","https://openalex.org/W2335364913","https://openalex.org/W2396679523","https://openalex.org/W2898286558","https://openalex.org/W3024383408","https://openalex.org/W4233370122","https://openalex.org/W4243746187","https://openalex.org/W4388301735","https://openalex.org/W6656417943","https://openalex.org/W6657846037"],"related_works":["https://openalex.org/W2224296499","https://openalex.org/W2092279282","https://openalex.org/W4388301735","https://openalex.org/W2399473015","https://openalex.org/W1980388161","https://openalex.org/W2036806484","https://openalex.org/W4388247577","https://openalex.org/W2561803329","https://openalex.org/W1937781460","https://openalex.org/W4407170190"],"abstract_inverted_index":{"New":[0],"Markers":[1],"of":[2,9,33,45,48,53,71,82,89,111,133,143,156,172,202,212,222,237,249,269,285,298,302,312,322,342,347,353,379,393,399,409,413,421,426,433],"Oxidative":[3,170],"Damage":[4],"to":[5,64,108,225,262,319,339,367,389],"Macromolecules":[6],"The":[7,51,200],"presence":[8,248],"free":[10,25,54,72,274],"radicals":[11,55,73,122],"in":[12,27,42,62,178,196,241,406,429],"biological":[13,189],"material":[14],"has":[15],"been":[16],"discovered":[17],"some":[18],"50":[19],"years":[20],"ago.":[21],"In":[22],"physiological":[23,49],"conditions,":[24],"radicals,":[26,116,275],"the":[28,31,43,60,109,130,210,215,235,247,257,279,299,320,336,345,370,407,410,430],"first":[29],"place":[30],"ones":[32],"oxygen":[34],"and":[35,40,92,94,104,120,123,140,150,167,182,191,239,254,276,282,314,316,344,356,397,424],"nitrogen,":[36],"are":[37,153,256,267,374],"continuously":[38],"synthesized":[39],"involved":[41],"regulation":[44],"a":[46,187,219,340],"series":[47],"processes.":[50],"excess":[52],"is":[56,174,218,278,294],"efficiently":[57],"eliminated":[58],"from":[59],"body":[61],"order":[63],"prevent":[65],"their":[66,179,193],"toxic":[67],"effects.":[68],"Toxic":[69],"effects":[70],"may":[74,205,364,385],"be":[75],"classified":[76],"into":[77],"three":[78],"groups:":[79],"a)":[80],"change":[81],"intracellular":[83],"redox":[84],"potential,":[85],"b)":[86],"oxidative":[87,223,242,263,286,382,418],"modification":[88,171,194,204,287],"lipids,":[90],"proteins":[91,173,313],"DNA,":[93,337,368],"c)":[95],"gene":[96],"activation.":[97],"Lipid":[98],"peroxidation":[99,361],"involving":[100],"cell":[101],"membranes,":[102],"lipoproteins":[103],"other":[105],"molecules":[106],"leads":[107],"production":[110,321],"primary":[112],"high-reactive":[113],"intermediaries":[114],"(alkyl":[115],"conjugated":[117],"dienes,":[118],"peroxy-":[119],"alkoxyl":[121],"lipid":[124,134,144,360],"hydroperoxide),":[125],"whose":[126],"further":[127],"breakdown":[128],"generates":[129],"secondary":[131,181,300],"products":[132,142,330,362],"peroxidation:":[135,145],"short-chain":[136],"evaporable":[137],"hydrocarbons,":[138],"aldehydes":[139],"final":[141],"isoprostanes,":[146],"MDA,":[147],"4-hydroxy-2,":[148],"3-transnonenal":[149],"4,5-dihydroxydecenal":[151],"which":[152,231,373],"important":[154,296],"mediators":[155],"atherosclerosis,":[157],"coronary":[158],"disease,":[159,394],"acute":[160],"myocardial":[161],"infarction,":[162],"rheumatoid":[163],"arthritis,":[164],"systemic":[165],"sclerosis":[166],"lupus":[168],"erythematodes.":[169],"manifested":[175],"by":[176,228,273,289,417],"changes":[177],"primary,":[180],"tertiary":[183],"structures.":[184],"Proteins":[185],"have":[186],"specific":[188,220],"function,":[190],"therefore":[192],"results":[195],"unique":[197],"functional":[198],"consequences.":[199],"nature":[201],"protein":[203],"provide":[206],"valid":[207],"information":[208],"on":[209],"type":[211],"oxidants":[213],"causing":[214],"damage.":[216],"Chlorotyrosyl":[217],"marker":[221,284],"damage":[224,271,415],"tyrosine":[226],"caused":[227,272,416],"HOCl":[229],"action,":[230],"most":[232,260,280],"commonly":[233],"reflects":[234],"involvement":[236],"neutrophils":[238],"monocytes":[240],"stress,":[243,264,419],"while":[244],"nitrotyrosyl":[245],"indicates":[246],"higher":[250],"peroxy-nitrite":[251],"synthesis.":[252],"Methyonin":[253],"cysteine":[255],"amino":[258,310],"acids":[259],"sensitive":[261,283],"carbonyl":[265],"groups":[266,311],"markers":[268],"severe":[270],"di-tyrosyl":[277],"significant":[281],"made":[288],"\u03b3":[290],"rays.":[291],">Carbonyl":[292],"stress<":[293],"an":[295,380,390],"form":[297],"oxidation":[301],"proteins,":[303],"where":[304],"reducing":[305],"sugars":[306],"non-enzymatically":[307],"react":[308],"with":[309],"lipids":[315],"give":[317],"rise":[318],"covalent":[323],"compounds":[324],"known":[325],"as":[326],"advanced":[327],"glycosylated":[328],"end":[329],"(AGE-products).":[331],"A":[332],"hydroxyl":[333],"radical":[334],"damages":[335],"leading":[338],"loss":[341],"base":[343],"formation":[346],"abasic":[348],"sites":[349],"(AP":[350],"sites),":[351],"break":[352],"DNA":[354],"chain":[355],"sugar":[357],"modification.":[358],"Final":[359],"(MDA)":[363],"covalently":[365],"bind":[366],"producing":[369],">DNA":[371],"radicals<":[372],"responsible":[375],"for":[376],"mutations.":[377],"Measurement":[378],"adequate":[381],"stress":[383],"biomarker":[384],"not":[386],"only":[387],"point":[388],"early":[391,431],"onset":[392],"its":[395],"progression":[396],"assessment":[398],"therapy":[400],"effectiveness,":[401],"but":[402],"can":[403],"also":[404],"help":[405],"clarification":[408],"pathophysiological":[411],"mechanisms":[412],"tissue":[414],"prediction":[420],"disease":[422],"prognosis":[423],"choice":[425],"appropriate":[427],"treatment":[428],"stages":[432],"disease.":[434]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
