{"id":"https://openalex.org/W2004672217","doi":"https://doi.org/10.1097/00003246-199310001-00005","title":"Preclinical review of anti-tumor necrosis factor monoclonal antibodies","display_name":"Preclinical review of anti-tumor necrosis factor monoclonal antibodies","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2004672217","doi":"https://doi.org/10.1097/00003246-199310001-00005","mag":"2004672217","pmid":"https://pubmed.ncbi.nlm.nih.gov/8403982"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-199310001-00005","doi":"https://doi.org/10.1097/00003246-199310001-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199310001-00005","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113592924","display_name":"Mark Bodmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARK BODMER","raw_affiliation_strings":["Celltech Research, Slough, United Kingdom","Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celltech Research, Slough, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013262267","display_name":"Michael A. Fournel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL A. FOURNEL","raw_affiliation_strings":["From Celltech Research (Dr. Bodmer), Slough, United Kingdom","Miles Research Center (Mr. Fournel), West Haven, CT","Oklahoma Medical Research Foundation (Dr. Hinshaw), Oklahoma City, OK","Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Celltech Research (Dr. Bodmer), Slough, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Miles Research Center (Mr. Fournel), West Haven, CT","institution_ids":[]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation (Dr. Hinshaw), Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111508864","display_name":"Lerner B. Hinshaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LERNER B. HINSHAW","raw_affiliation_strings":["From Celltech Research (Dr. Bodmer), Slough, United Kingdom","Miles Research Center (Mr. Fournel), West Haven, CT","Oklahoma Medical Research Foundation (Dr. Hinshaw), Oklahoma City, OK","Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Celltech Research (Dr. Bodmer), Slough, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Miles Research Center (Mr. Fournel), West Haven, CT","institution_ids":[]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation (Dr. Hinshaw), Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5021,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.92202005,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"Supplement","first_page":"S441","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.968999981880188},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anti-tnf-monoclonal-antibody","display_name":"anti-TNF monoclonal antibody","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sepsis-pathogenesis","display_name":"sepsis pathogenesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bacterial-challenge","display_name":"bacterial challenge","score":0.6890000104904175},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.871999979019165},{"id":"https://openalex.org/keywords/animal-models-of-sepsis","display_name":"animal models of sepsis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/inflammatory-cascade","display_name":"inflammatory cascade","score":0.5009999871253967},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8725250959396362},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7771986722946167},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7327815890312195},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6343718767166138},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6152860522270203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5784879326820374},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5309198498725891},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5016894340515137},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4382857382297516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15146532654762268}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-199310001-00005","doi":"https://doi.org/10.1097/00003246-199310001-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199310001-00005","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:8403982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8403982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4300520484","https://openalex.org/W2009160426","https://openalex.org/W2416945871","https://openalex.org/W2088699287","https://openalex.org/W1979714786","https://openalex.org/W2184302729","https://openalex.org/W2395767845","https://openalex.org/W2062205810","https://openalex.org/W194144591","https://openalex.org/W4322387790"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2],"the":[3,7,15,23,43,46,64,69,87,96,100,117,128,131,134,137,152,189,194,209,242,265],"preclinical":[4,24],"evidence":[5],"for":[6,29],"role":[8,94],"of":[9,17,26,48,66,71,89,91,103,130,136,154,161,175,211,245,267],"tumor":[10],"necrosis":[11],"factor":[12],"(TNF)":[13],"in":[14,57,95,164,250,264],"pathogenesis":[16,135],"septic":[18,195,253,269],"shock":[19,196,254],"and":[20,59,68,99,112,167,187,220,230,247],"to":[21,42,54,63,133,227,240],"assess":[22],"efficacy":[25],"anti-TNF":[27,72,104,162,200,233,237],"therapies":[28,105,234],"this":[30,49,181],"clinical":[31,139],"problem.":[32],"DATA":[33,120,157],"SOURCES:":[34],"The":[35,159],"international":[36],"English":[37],"language":[38],"literature":[39],"from":[40],"1986":[41],"present":[44],"formed":[45],"basis":[47,153],"review.":[50],"MEDLINE":[51],"was":[52],"used":[53],"identify":[55],"pertinent":[56],"vitro":[58],"animal":[60,111,255],"studies":[61,83,123,148],"pertaining":[62],"pathobiology":[65],"TNF":[67,212,246],"use":[70],"therapies,":[73],"with":[74,199],"special":[75],"emphasis":[76],"on":[77,86,127,151],"antibody":[78],"approaches.":[79],"STUDY":[80],"SELECTION:":[81],"Those":[82],"that":[84,109,170,180,223],"focused":[85],"mechanisms":[88],"action":[90],"TNF,":[92],"its":[93],"inflammatory":[97],"cascade,":[98],"potential":[101],"uses":[102],"were":[106,124,149,171],"emphasized.":[107],"Investigations":[108],"described":[110],"human":[113,138,268],"results":[114],"served":[115],"as":[116,236],"primary":[118],"database.":[119],"EXTRACTION:":[121],"Animal":[122],"selected":[125,150],"based":[126],"relevance":[129],"model":[132],"sepsis":[140],"syndrome.":[141,197],"Where":[142],"they":[143],"provided":[144],"supportive":[145],"evidence,":[146],"patient":[147],"study":[155],"design.":[156],"SYNTHESIS:":[158],"administration":[160],"antibodies":[163,202,238],"baboons,":[165],"monkeys,":[166],"other":[168,214],"species":[169],"administered":[172],"lethal":[173,252],"doses":[174],"bacteria":[176],"or":[177],"endotoxin":[178],"suggest":[179],"approach":[182],"may":[183,224],"limit":[184],"organ":[185,228],"damage":[186],"decrease":[188],"mortality":[190],"rate":[191],"caused":[192],"by":[193],"Therapy":[198],"monoclonal":[201],"is":[203],"reviewed.":[204],"CONCLUSIONS:":[205],"Bacterial":[206],"challenge":[207],"induces":[208],"release":[210],"(among":[213],"mediators),":[215],"which":[216],"exerts":[217],"both":[218],"physiologic":[219],"toxic":[221],"effects":[222,244],"ultimately":[225],"lead":[226],"dysfunction":[229],"death.":[231],"New":[232],"such":[235],"appear":[239],"attenuate":[241],"injurious":[243],"promote":[248],"survival":[249],"otherwise":[251],"models,":[256],"suggesting":[257],"a":[258],"similar":[259],"benefit":[260],"might":[261],"be":[262],"obtained":[263],"treatment":[266],"shock.":[270]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}