{"id":"https://openalex.org/W2004666525","doi":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","title":"aV integrins and TGF\u2010\u03b2\u2010induced EMT: a circle of regulation","display_name":"aV integrins and TGF\u2010\u03b2\u2010induced EMT: a circle of regulation","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2004666525","doi":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","mag":"2004666525","pmid":"https://pubmed.ncbi.nlm.nih.gov/21883891","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290750"},"language":"en","primary_location":{"id":"doi:10.1111/j.1582-4934.2011.01419.x","doi":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","pdf_url":null,"source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290750","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017300601","display_name":"Fahmy A. Mamuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahmy A. Mamuya","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010301642","display_name":"Melinda K. Duncan","orcid":"https://orcid.org/0000-0003-1570-322X","observed_orcids":["https://orcid.org/0000-0003-1570-322X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melinda K. Duncan","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010301642"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":null,"fwci":0.763,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.5987055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"16","issue":"3","first_page":"445","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.4717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/integrin-alphav","display_name":"ITGAV","score":0.9729999899864197},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/integrin-conformational-change","display_name":"integrin conformational change","score":0.6980000138282776},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cell-matrix-adhesion","display_name":"cell-matrix adhesion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.9049999713897705},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7953804135322571},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.741553544998169},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6295891404151917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.567410945892334},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5090429186820984},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4888855516910553},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4809243381023407},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4607241451740265},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.45805609226226807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42899200320243835},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36708128452301025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2855908274650574},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.22156429290771484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08493581414222717},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039564","descriptor_name":"Integrin alphaV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039564","descriptor_name":"Integrin alphaV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1111/j.1582-4934.2011.01419.x","doi":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2011.01419.x","pdf_url":null,"source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2581886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290750","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3290750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290750","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:21883891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21883891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.657.8257","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.8257","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290750/pdf/nihms319784.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.2284","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.2284","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/98/jcmm0016-0445.PMC3290750.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2581886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290750","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000876997","display_name":"The Influence of Capsule Composition on Lens Biology","funder_award_id":"R01EY015279","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W69784355","https://openalex.org/W111650051","https://openalex.org/W202362946","https://openalex.org/W1497005060","https://openalex.org/W1500321338","https://openalex.org/W1542719901","https://openalex.org/W1565561072","https://openalex.org/W1575754639","https://openalex.org/W1577573926","https://openalex.org/W1584463243","https://openalex.org/W1593885715","https://openalex.org/W1606352234","https://openalex.org/W1760215417","https://openalex.org/W1835561921","https://openalex.org/W1927590837","https://openalex.org/W1931073059","https://openalex.org/W1964081206","https://openalex.org/W1972429412","https://openalex.org/W1973662849","https://openalex.org/W1976324983","https://openalex.org/W1977885055","https://openalex.org/W1979988883","https://openalex.org/W1982002890","https://openalex.org/W1983628734","https://openalex.org/W1984872320","https://openalex.org/W1985301994","https://openalex.org/W1986411839","https://openalex.org/W1986612792","https://openalex.org/W1987355699","https://openalex.org/W1991031555","https://openalex.org/W1994185723","https://openalex.org/W1994247511","https://openalex.org/W1995592152","https://openalex.org/W1996118868","https://openalex.org/W1996556203","https://openalex.org/W1998975199","https://openalex.org/W2000099153","https://openalex.org/W2001093897","https://openalex.org/W2001573485","https://openalex.org/W2005909933","https://openalex.org/W2009001235","https://openalex.org/W2011610612","https://openalex.org/W2013381560","https://openalex.org/W2013445858","https://openalex.org/W2015007786","https://openalex.org/W2016273963","https://openalex.org/W2016715162","https://openalex.org/W2018822666","https://openalex.org/W2025647419","https://openalex.org/W2027528715","https://openalex.org/W2029763637","https://openalex.org/W2032044096","https://openalex.org/W2032942532","https://openalex.org/W2034207830","https://openalex.org/W2035653659","https://openalex.org/W2036472425","https://openalex.org/W2036968620","https://openalex.org/W2038569449","https://openalex.org/W2038939944","https://openalex.org/W2040916923","https://openalex.org/W2042921968","https://openalex.org/W2044069347","https://openalex.org/W2044570850","https://openalex.org/W2049423709","https://openalex.org/W2050883173","https://openalex.org/W2050928977","https://openalex.org/W2052553464","https://openalex.org/W2052917153","https://openalex.org/W2053794079","https://openalex.org/W2054171565","https://openalex.org/W2054797017","https://openalex.org/W2055183929","https://openalex.org/W2056127350","https://openalex.org/W2057067749","https://openalex.org/W2057287059","https://openalex.org/W2059253566","https://openalex.org/W2059552745","https://openalex.org/W2064852464","https://openalex.org/W2065179220","https://openalex.org/W2066521983","https://openalex.org/W2072103796","https://openalex.org/W2078864257","https://openalex.org/W2078954749","https://openalex.org/W2082438422","https://openalex.org/W2084028385","https://openalex.org/W2086069051","https://openalex.org/W2086364694","https://openalex.org/W2087218656","https://openalex.org/W2087963453","https://openalex.org/W2089786697","https://openalex.org/W2091243945","https://openalex.org/W2093898615","https://openalex.org/W2094280155","https://openalex.org/W2097839537","https://openalex.org/W2102298863","https://openalex.org/W2106143687","https://openalex.org/W2106528753","https://openalex.org/W2110292482","https://openalex.org/W2110705886","https://openalex.org/W2114286636","https://openalex.org/W2118650242","https://openalex.org/W2118719170","https://openalex.org/W2126310598","https://openalex.org/W2126889260","https://openalex.org/W2132129310","https://openalex.org/W2136280424","https://openalex.org/W2136819289","https://openalex.org/W2139930644","https://openalex.org/W2140475188","https://openalex.org/W2145002455","https://openalex.org/W2145280913","https://openalex.org/W2147000598","https://openalex.org/W2150582334","https://openalex.org/W2153284298","https://openalex.org/W2154568166","https://openalex.org/W2154589460","https://openalex.org/W2158075507","https://openalex.org/W2161626694","https://openalex.org/W2165046771","https://openalex.org/W2166424759","https://openalex.org/W2172114097","https://openalex.org/W2318767049","https://openalex.org/W2991800179","https://openalex.org/W3024117005","https://openalex.org/W3102273949","https://openalex.org/W3151653929","https://openalex.org/W4294352168","https://openalex.org/W6688943250"],"related_works":["https://openalex.org/W7099851772","https://openalex.org/W7095768232","https://openalex.org/W1996556203","https://openalex.org/W1999614450","https://openalex.org/W2516230041","https://openalex.org/W1610148497","https://openalex.org/W7098114913","https://openalex.org/W2112195516","https://openalex.org/W2096798007","https://openalex.org/W7160681134"],"abstract_inverted_index":{"Abstract":[0],"EMT":[1,15,26,35,58,200],"and":[2,8,53,82,107,129,148,152,185,216],"pathogenesis:":[3],"the":[4,6,9,62,77,169,190,209],"good,":[5],"bad":[7],"ugly":[10],"TGF\u2010b\u2014a":[11],"central":[12],"player":[13],"in":[14,17,20,74],"Changes":[16],"cell\u2013cell/cell\u2013ECM":[18],"adhesion":[19],"EMT\u2014the":[21],"role":[22,195],"of":[23,31,66,79,99,122,171,183,193,211],"integrins":[24,37,147,184],"during":[25,34,57,150,188,196,219],"TGF\u2010b":[27,39,52],"as":[28,158,225],"a":[29,97,119,226],"regulator":[30],"integrin":[32,54,215],"expression":[33],"aV":[36],"activate":[38],"\u2010":[40,45],"Conformational":[41,46],"change":[42,47],"activation":[43,48],"mechanism":[44,49,192],"with":[50,131],"proteolysis":[51],"signalling":[55,87,111,166,218],"cross\u2010talk":[56,130,144],"Disease":[59],"perspectives":[60],"Completing":[61],"circle":[63,210],"Acknowledgements":[64],"Conflicts":[65],"interest":[67],"Transforming":[68],"growth":[69],"factor\u2010\u03b2":[70],"(TGF\u2010\u03b2)":[71],"has":[72],"roles":[73],"embryonic":[75],"development,":[76],"prevention":[78],"inappropriate":[80],"inflammation":[81],"tumour":[83],"suppression.":[84],"However,":[85,109,163],"TGF\u2010\u03b2":[86,110,149,186,217,220],"also":[88],"regulates":[89],"pathological":[90,199],"epithelial\u2010to\u2010mesenchymal":[91],"transition":[92],"(EMT),":[93],"inducing":[94],"or":[95],"progressing":[96],"number":[98],"diseases":[100],"ranging":[101],"from":[102],"inflammatory":[103],"disorders,":[104],"to":[105,134,173,229],"fibrosis":[106],"cancer.":[108],"does":[112],"not":[113,202],"proceed":[114],"linearly":[115],"but":[116],"rather":[117],"induces":[118],"complex":[120,165],"network":[121,167],"cascades":[123],"that":[124],"mutually":[125],"influence":[126],"each":[127],"other":[128,132],"pathways":[133],"successfully":[135],"induce":[136],"EMT.":[137],"Particularly,":[138],"there":[139],"is":[140,201],"substantial":[141],"evidence":[142],"for":[143,160],"between":[145,213],"\u03b1V":[146,214],"EMT,":[151,189,222],"anti\u2010integrin":[153],"therapeutics":[154,172],"are":[155],"under":[156],"development":[157,170],"treatments":[159],"TGF\u2010\u03b2\u2010related":[161],"disorders.":[162,233],"TGF\u2010\u03b2\u2019s":[164],"makes":[168],"block":[174],"TGF\u2010\u03b2\u2010mediated":[175,232],"pathology":[176],"challenging.":[177],"Moreover,":[178],"despite":[179],"our":[180],"current":[181],"understanding":[182],"function":[187],"precise":[191],"their":[194],"physiological":[197],"versus":[198],"fully":[203],"understood.":[204],"This":[205],"review":[206],"focuses":[207],"on":[208],"regulation":[212],"induced":[221],"which":[223],"pose":[224],"significant":[227],"driver":[228],"many":[230],"known":[231]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
