{"id":"https://openalex.org/W2004611201","doi":"https://doi.org/10.1007/s00018-012-1106-2","title":"The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin \u03b2 and ADAM10","display_name":"The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin \u03b2 and ADAM10","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W2004611201","doi":"https://doi.org/10.1007/s00018-012-1106-2","mag":"2004611201","pmid":"https://pubmed.ncbi.nlm.nih.gov/22940918","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535375"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-012-1106-2","doi":"https://doi.org/10.1007/s00018-012-1106-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-012-1106-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-012-1106-2.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00018-012-1106-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039052823","display_name":"Tamara Jefferson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tamara Jefferson","raw_affiliation_strings":["Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076623682","display_name":"Ulrich auf dem Keller","orcid":"https://orcid.org/0000-0002-3431-7415","observed_orcids":["https://orcid.org/0000-0002-3431-7415"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257820","display_name":"Institute of Molecular Health Sciences","ror":"https://ror.org/05q2cwx50","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257820"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA","CH"],"is_corresponding":false,"raw_author_name":"Ulrich auf dem Keller","raw_affiliation_strings":["Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada","Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich, ETH Hoenggerberg, HPM D24, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]},{"raw_affiliation_string":"Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich, ETH Hoenggerberg, HPM D24, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021171892","display_name":"Caroline L. Bellac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Caroline Bellac","raw_affiliation_strings":["Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087949778","display_name":"Verena V. Metz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena V. Metz","raw_affiliation_strings":["Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064323972","display_name":"Claudia Broder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Broder","raw_affiliation_strings":["Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073617906","display_name":"Jana Hedrich","orcid":"https://orcid.org/0000-0002-2664-0212","observed_orcids":["https://orcid.org/0000-0002-2664-0212"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Hedrich","raw_affiliation_strings":["Institute of Physiology and Pathophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014052805","display_name":"Anke Ohler","orcid":"https://orcid.org/0000-0002-4036-4744","observed_orcids":["https://orcid.org/0000-0002-4036-4744"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anke Ohler","raw_affiliation_strings":["Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034443501","display_name":"Wladislaw Maier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wladislaw Maier","raw_affiliation_strings":["Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030706001","display_name":"Viktor Magdolen","orcid":"https://orcid.org/0000-0003-0167-793X","observed_orcids":["https://orcid.org/0000-0003-0167-793X"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Viktor Magdolen","raw_affiliation_strings":["Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020009807","display_name":"Erwin E. Sterchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Erwin Sterchi","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090568840","display_name":"Judith S. Bond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith S. Bond","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068544312","display_name":"Arumugam Jayakumar","orcid":"https://orcid.org/0000-0002-1284-4222","observed_orcids":["https://orcid.org/0000-0002-1284-4222"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arumugam Jayakumar","raw_affiliation_strings":["Department of Experimental Therapeutics, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060091206","display_name":"Heiko Traupe","orcid":"https://orcid.org/0000-0001-6104-3483","observed_orcids":["https://orcid.org/0000-0001-6104-3483"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko Traupe","raw_affiliation_strings":["Department of Dermatology, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006634561","display_name":"Athena Chalaris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Athena Chalaris","raw_affiliation_strings":["Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089057275","display_name":"Stefan Rose\u2010John","orcid":"https://orcid.org/0000-0002-7519-3279","observed_orcids":["https://orcid.org/0000-0002-7519-3279"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Rose-John","raw_affiliation_strings":["Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014696581","display_name":"Claus U. Pietrzik","orcid":"https://orcid.org/0000-0002-1202-5489","observed_orcids":["https://orcid.org/0000-0002-1202-5489"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus U. Pietrzik","raw_affiliation_strings":["Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012325622","display_name":"Rolf Postina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Postina","raw_affiliation_strings":["Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053252393","display_name":"Christopher M. Overall","orcid":"https://orcid.org/0000-0001-5844-2731","observed_orcids":["https://orcid.org/0000-0001-5844-2731"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher M. Overall","raw_affiliation_strings":["Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073470059","display_name":"Christoph Becker\u2010Pauly","orcid":"https://orcid.org/0000-0002-5100-9916","observed_orcids":["https://orcid.org/0000-0002-5100-9916"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph Becker-Pauly","raw_affiliation_strings":["Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","Unit for Degradomics of the Protease Web, Christian-Albrechts-University, Rudolf-H\u00f6ber-Str. 1, 24118, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Christian-Albrechts-University, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Unit for Degradomics of the Protease Web, Christian-Albrechts-University, Rudolf-H\u00f6ber-Str. 1, 24118, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5073470059"],"corresponding_institution_ids":["https://openalex.org/I32021983"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":4.5711,"has_fulltext":true,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95748246,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"70","issue":"2","first_page":"309","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meprin-beta","display_name":"meprin beta","score":0.9049999713897705},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protease-substrates","display_name":"protease substrates","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tail","display_name":"tail","score":0.6069999933242798},{"id":"https://openalex.org/keywords/n-terminal-peptide","display_name":"N-terminal peptide","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.7509999871253967},{"id":"https://openalex.org/keywords/elafin","display_name":"elafin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fetuin-a","display_name":"fetuin-A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7300000190734863},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.7889999747276306},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.8680418133735657},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.7153639793395996},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5955384969711304},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5221726894378662},{"id":"https://openalex.org/C7860815","wikidata":"https://www.wikidata.org/wiki/Q258658","display_name":"Protein precursor","level":3,"score":0.5094106793403625},{"id":"https://openalex.org/C2778715156","wikidata":"https://www.wikidata.org/wiki/Q17709536","display_name":"ADAM10","level":5,"score":0.49935388565063477},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4974391758441925},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49442338943481445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49019747972488403},{"id":"https://openalex.org/C2776224515","wikidata":"https://www.wikidata.org/wiki/Q102253084","display_name":"ADAMTS","level":5,"score":0.4684094786643982},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.4651537835597992},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4519285559654236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44012048840522766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4379878342151642},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4151609539985657},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.3110046982765198},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21993479132652283},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053492","descriptor_name":"Elafin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060749","descriptor_name":"alpha-2-HS-Glycoprotein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1007/s00018-012-1106-2","doi":"https://doi.org/10.1007/s00018-012-1106-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-012-1106-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-012-1106-2.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2538357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3535375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmid:22940918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22940918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.746","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.746","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/30/73/18_2012_Article_1106.PMC3535375.pdf","raw_type":"text"},{"id":"pmh:doi:10.48350/43256","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/114428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:43256","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/43256/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1210988","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1210988","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/62792","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/62792","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Life Sciences, 70 (2)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000062792","doi":"https://doi.org/10.3929/ethz-b-000062792","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000062792","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.48350/43256","doi":"https://doi.org/10.48350/43256","is_oa":true,"landing_page_url":"https://doi.org/10.48350/43256","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:2472319038","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2Fs00018-012-1106-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/s00018-012-1106-2","doi":"https://doi.org/10.1007/s00018-012-1106-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-012-1106-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-012-1106-2.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G232086198","display_name":"Meprins-Metalloproteinases of the Kidney and Intestine","funder_award_id":"R01DK019691","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G25392554","display_name":"CANDIDATE GENE FOR DIABETIC NEPHROPATHY--MEPRIN BETA","funder_award_id":"R01DK054625","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2693665147","display_name":null,"funder_award_id":"SFB 877","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2724716389","display_name":null,"funder_award_id":"DK-19691","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4990778399","display_name":"Mucosal protease and their inhibitors in inflammatory bowel disease: From etiopathogenetic insight to innovative therapy","funder_award_id":"200931","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8088638102","display_name":"MEPRINS - METALLOPROTEINASES OF THE KIDNEY AND INTESTINE","funder_award_id":"R56DK019691","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320326641","display_name":"Exzellenzclusters Entz\u00fcndungsforschung","ror":"https://ror.org/00ygmry26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004611201.pdf","grobid_xml":"https://content.openalex.org/works/W2004611201.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1490736749","https://openalex.org/W1537234916","https://openalex.org/W1596272559","https://openalex.org/W1605584393","https://openalex.org/W1608048686","https://openalex.org/W1923386801","https://openalex.org/W1967314752","https://openalex.org/W1968558772","https://openalex.org/W1968872270","https://openalex.org/W1975877815","https://openalex.org/W1976097978","https://openalex.org/W1978500529","https://openalex.org/W1978575307","https://openalex.org/W1978591675","https://openalex.org/W1979615635","https://openalex.org/W1981567427","https://openalex.org/W1984065470","https://openalex.org/W1989091925","https://openalex.org/W1991380003","https://openalex.org/W1992660677","https://openalex.org/W1993876644","https://openalex.org/W1995518402","https://openalex.org/W1997538331","https://openalex.org/W2000128643","https://openalex.org/W2000299144","https://openalex.org/W2001497601","https://openalex.org/W2005037124","https://openalex.org/W2005712482","https://openalex.org/W2009605886","https://openalex.org/W2009655341","https://openalex.org/W2010412209","https://openalex.org/W2010794316","https://openalex.org/W2012195037","https://openalex.org/W2014154752","https://openalex.org/W2014539316","https://openalex.org/W2019771217","https://openalex.org/W2021812153","https://openalex.org/W2022851134","https://openalex.org/W2023636665","https://openalex.org/W2032004515","https://openalex.org/W2042253157","https://openalex.org/W2043786976","https://openalex.org/W2044841261","https://openalex.org/W2045804962","https://openalex.org/W2045990794","https://openalex.org/W2048164934","https://openalex.org/W2061945526","https://openalex.org/W2062476429","https://openalex.org/W2063003823","https://openalex.org/W2068042361","https://openalex.org/W2068627446","https://openalex.org/W2069508712","https://openalex.org/W2070941753","https://openalex.org/W2071485699","https://openalex.org/W2074912245","https://openalex.org/W2075882731","https://openalex.org/W2077916606","https://openalex.org/W2080311659","https://openalex.org/W2081282825","https://openalex.org/W2087561530","https://openalex.org/W2088682566","https://openalex.org/W2089389981","https://openalex.org/W2092133427","https://openalex.org/W2093550369","https://openalex.org/W2097033861","https://openalex.org/W2097817417","https://openalex.org/W2101100934","https://openalex.org/W2105173724","https://openalex.org/W2111630252","https://openalex.org/W2112078820","https://openalex.org/W2118070479","https://openalex.org/W2122215582","https://openalex.org/W2132290892","https://openalex.org/W2133341222","https://openalex.org/W2135925543","https://openalex.org/W2136588287","https://openalex.org/W2137043026","https://openalex.org/W2137592631","https://openalex.org/W2138710425","https://openalex.org/W2149152049","https://openalex.org/W2149677668","https://openalex.org/W2157917051","https://openalex.org/W2160994404","https://openalex.org/W2162767053","https://openalex.org/W2163527113","https://openalex.org/W2164118220","https://openalex.org/W2398722480","https://openalex.org/W2470266050","https://openalex.org/W2590151858","https://openalex.org/W4320800236"],"related_works":["https://openalex.org/W7096016803","https://openalex.org/W2472319038","https://openalex.org/W2965179108","https://openalex.org/W2036465442","https://openalex.org/W7098734571","https://openalex.org/W6945278785","https://openalex.org/W2009655341","https://openalex.org/W1492117196","https://openalex.org/W2568990702","https://openalex.org/W6945266939"],"abstract_inverted_index":{"The":[0],"in":[1,7,97,104,142,170],"vivo":[2,143],"roles":[3],"of":[4,34,44,77,154,173],"meprin":[5,23,73,93],"metalloproteases":[6],"pathophysiological":[8,179],"conditions":[9],"remain":[10],"elusive.":[11],"Substrates":[12],"define":[13],"protease":[14,174],"roles.":[15],"Therefore,":[16],"to":[17],"identify":[18],"natural":[19,163],"substrates":[20,54,112,161],"for":[21,41,165,177],"human":[22],"\u03b1":[24],"and":[25,46,64,89,119,126,149,158,162],"\u03b2":[26,74],"we":[27,55,85],"employed":[28],"TAILS":[29],"(terminal":[30],"amine":[31],"isotopic":[32],"labeling":[33],"substrates),":[35],"a":[36],"proteomics":[37],"approach":[38],"that":[39,60],"enriches":[40],"N-terminal":[42],"peptides":[43],"proteins":[45],"cleavage":[47,76,83,136],"fragments.":[48],"Of":[49],"the":[50,78,134,171],"151":[51],"new":[52,168],"extracellular":[53,114],"identified,":[56],"it":[57],"was":[58],"notable":[59],"ADAM10":[61,100],"(a":[62],"disintegrin":[63],"metalloprotease":[65],"domain-containing":[66],"protein":[67],"10)-the":[68],"constitutive":[69],"\u03b1-secretase-is":[70],"activated":[71],"by":[72,123,139,146],"through":[75],"propeptide.":[79],"To":[80],"validate":[81],"this":[82,95],"event,":[84],"expressed":[86],"recombinant":[87],"proADAM10":[88],"after":[90],"preincubation":[91],"with":[92,130],"\u03b2,":[94],"resulted":[96],"significantly":[98],"elevated":[99],"activity.":[101],"Cellular":[102],"expression":[103],"murine":[105],"primary":[106],"fibroblasts":[107],"confirmed":[108,145],"activation.":[109],"Other":[110],"novel":[111],"including":[113],"matrix":[115],"proteins,":[116],"growth":[117],"factors":[118],"inhibitors":[120,164],"were":[121,144],"validated":[122],"western":[124],"analyses":[125],"enzyme":[127],"activity":[128,175],"assays":[129],"Edman":[131],"sequencing":[132],"confirming":[133],"exact":[135],"sites":[137],"identified":[138],"TAILS.":[140],"Cleavages":[141],"comparing":[147],"wild-type":[148],"meprin(-/-)":[150],"mice.":[151],"Our":[152],"finding":[153],"cystatin":[155],"C,":[156],"elafin":[157],"fetuin-A":[159],"as":[160],"meprins":[166],"reveal":[167],"mechanisms":[169],"regulation":[172],"important":[176],"understanding":[178],"processes.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}