{"id":"https://openalex.org/W2004607001","doi":"https://doi.org/10.1016/0024-3205(77)90147-3","title":"Lowering of ethanol-derived circulating blood acetaldehyde in rats by D-penicillamine","display_name":"Lowering of ethanol-derived circulating blood acetaldehyde in rats by D-penicillamine","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2004607001","doi":"https://doi.org/10.1016/0024-3205(77)90147-3","mag":"2004607001","pmid":"https://pubmed.ncbi.nlm.nih.gov/556793"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(77)90147-3","doi":"https://doi.org/10.1016/0024-3205(77)90147-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(77)90147-3","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045095689","display_name":"Herbert T. Nagasawa","orcid":"https://orcid.org/0000-0002-9106-1823","observed_orcids":["https://orcid.org/0000-0002-9106-1823"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert T. Nagasawa","raw_affiliation_strings":["Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000844606","display_name":"David J. W. Goon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J.W. Goon","raw_affiliation_strings":["Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063856140","display_name":"Eugene G. DeMaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene G. DeMaster","raw_affiliation_strings":["Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105986993","display_name":"Carl S. Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl S. Alexander","raw_affiliation_strings":["Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratories, Veterans Administration Hospital, and the Departments of Medicinal Chemistry and of Medicine, University of Minnesota, Minneapolis, MN 55417, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":2.4696,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87064852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"20","issue":"1","first_page":"187","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.925000011920929},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.9599999785423279},{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/l-cystine","display_name":"L-cystine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.9419415593147278},{"id":"https://openalex.org/C2779348387","wikidata":"https://www.wikidata.org/wiki/Q421239","display_name":"Penicillamine","level":2,"score":0.9192570447921753},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.8545737862586975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8203543424606323},{"id":"https://openalex.org/C2778523461","wikidata":"https://www.wikidata.org/wiki/Q409665","display_name":"Disulfiram","level":2,"score":0.8133286237716675},{"id":"https://openalex.org/C30153976","wikidata":"https://www.wikidata.org/wiki/Q6011565","display_name":"Ethanol metabolism","level":3,"score":0.5743945240974426},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.522634744644165},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4858939051628113},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4514618217945099},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44728606939315796},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4344315528869629},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.42566701769828796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41772907972335815},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.40834060311317444},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36543968319892883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35958153009414673},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31955960392951965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12355780601501465},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001944","descriptor_name":"Breath Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(77)90147-3","doi":"https://doi.org/10.1016/0024-3205(77)90147-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(77)90147-3","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:556793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/556793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1959776573","https://openalex.org/W1980783747","https://openalex.org/W2002678920","https://openalex.org/W2015623363","https://openalex.org/W2018408638","https://openalex.org/W2018466510","https://openalex.org/W2025534559","https://openalex.org/W2026635928","https://openalex.org/W2034156633","https://openalex.org/W2065942834","https://openalex.org/W2066399293","https://openalex.org/W2066734475","https://openalex.org/W2070567241","https://openalex.org/W2186453453","https://openalex.org/W2292654070","https://openalex.org/W2424038536","https://openalex.org/W2439725228"],"related_works":["https://openalex.org/W43090319","https://openalex.org/W1990319677","https://openalex.org/W2066399293","https://openalex.org/W2025065453","https://openalex.org/W2093172763","https://openalex.org/W2263966597","https://openalex.org/W7097719558","https://openalex.org/W2101061861","https://openalex.org/W2045464687","https://openalex.org/W1976019663"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}