{"id":"https://openalex.org/W2004592773","doi":"https://doi.org/10.5732/cjc.013.10086","title":"Dysregulation of mTOR activity through LKB1 inactivation","display_name":"Dysregulation of mTOR activity through LKB1 inactivation","publication_year":2013,"publication_date":"2013-05-14","ids":{"openalex":"https://openalex.org/W2004592773","doi":"https://doi.org/10.5732/cjc.013.10086","mag":"2004592773","pmid":"https://pubmed.ncbi.nlm.nih.gov/23668926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3845579"},"language":"en","primary_location":{"id":"doi:10.5732/cjc.013.10086","doi":"https://doi.org/10.5732/cjc.013.10086","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.013.10086","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20585","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20585","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069603616","display_name":"Wei Zhou","orcid":"https://orcid.org/0000-0002-6783-9957","observed_orcids":["https://orcid.org/0000-0002-6783-9957"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["The Winship Cancer Institute, Department of Hematology and Oncology, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. wzhou2@emory.edu","The Winship Cancer Institute, Department of Hematology and Oncology, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Winship Cancer Institute, Department of Hematology and Oncology, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. wzhou2@emory.edu","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"The Winship Cancer Institute, Department of Hematology and Oncology, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064924657","display_name":"Adam I. Marcus","orcid":"https://orcid.org/0000-0003-0484-3569","observed_orcids":["https://orcid.org/0000-0003-0484-3569"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam I. Marcus","raw_affiliation_strings":["Department of Hematology and Oncology,","The Winship Cancer Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology,","institution_ids":[]},{"raw_affiliation_string":"The Winship Cancer Institute,","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024242252","display_name":"Paula M. Vertino","orcid":"https://orcid.org/0000-0001-6165-2019","observed_orcids":["https://orcid.org/0000-0001-6165-2019"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula M. Vertino","raw_affiliation_strings":["Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA","The Winship Cancer Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"The Winship Cancer Institute,","institution_ids":["https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":null,"fwci":0.2192,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.16323254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"8","first_page":"427","last_page":"433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9700000286102295},{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/stk11","display_name":"STK11","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6660000085830688},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.6809999942779541},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cancer-signaling","display_name":"cancer signaling","score":0.37400001287460327},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8214280009269714},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.6806070804595947},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.6383281350135803},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.6329360008239746},{"id":"https://openalex.org/C2777983448","wikidata":"https://www.wikidata.org/wiki/Q2745322","display_name":"STK11","level":5,"score":0.6118302941322327},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5602065920829773},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5593603253364563},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.4631127417087555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45933476090431213},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4278784990310669},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4184321165084839},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41018858551979065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3931238055229187},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3838239908218384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3758787214756012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37195008993148804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.159486323595047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1293831765651703},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.10982751846313477},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077004","descriptor_name":"Tuberous Sclerosis Complex 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077005","descriptor_name":"Tuberous Sclerosis Complex 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.5732/cjc.013.10086","doi":"https://doi.org/10.5732/cjc.013.10086","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.013.10086","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20585","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2843455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3845579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3845579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3845579","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chin J Cancer","raw_type":"Text"},{"id":"pmid:23668926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23668926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.663.1617","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.663.1617","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845579/pdf/cjc-32-08-427.pdf","raw_type":"text"},{"id":"mag:3152318033","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90720X/201308/47016052.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.5732/cjc.013.10086","doi":"https://doi.org/10.5732/cjc.013.10086","is_oa":true,"landing_page_url":"https://doi.org/10.5732/cjc.013.10086","pdf_url":"http://www.cancercommun.com/cn/entopdf.asp?ly=CJC&idno=20585","source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2783341341","display_name":"Pro-Oncogenic Role of LKB1 in NSCLC","funder_award_id":"R01CA140571","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5233773042","display_name":"Targeting Cell Signaling in lung cancer to enhance therapeutic efficacy","funder_award_id":"P01CA116676","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004592773.pdf","grobid_xml":"https://content.openalex.org/works/W2004592773.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W213605997","https://openalex.org/W1619256199","https://openalex.org/W1971402068","https://openalex.org/W1971479934","https://openalex.org/W1972762474","https://openalex.org/W1973186217","https://openalex.org/W1976760923","https://openalex.org/W1978763812","https://openalex.org/W1979417266","https://openalex.org/W1980979311","https://openalex.org/W1982245858","https://openalex.org/W1983602021","https://openalex.org/W1990278643","https://openalex.org/W1992257057","https://openalex.org/W2014782980","https://openalex.org/W2020064551","https://openalex.org/W2023165372","https://openalex.org/W2024256085","https://openalex.org/W2029938976","https://openalex.org/W2033406275","https://openalex.org/W2034935605","https://openalex.org/W2037645518","https://openalex.org/W2042386784","https://openalex.org/W2045129123","https://openalex.org/W2045815767","https://openalex.org/W2047392757","https://openalex.org/W2048626400","https://openalex.org/W2052498320","https://openalex.org/W2053848504","https://openalex.org/W2059825898","https://openalex.org/W2061278804","https://openalex.org/W2065725084","https://openalex.org/W2065902143","https://openalex.org/W2082108947","https://openalex.org/W2082937530","https://openalex.org/W2085888624","https://openalex.org/W2086589626","https://openalex.org/W2090165847","https://openalex.org/W2090588597","https://openalex.org/W2091625765","https://openalex.org/W2095081144","https://openalex.org/W2101952870","https://openalex.org/W2102891343","https://openalex.org/W2105256330","https://openalex.org/W2116651275","https://openalex.org/W2123558789","https://openalex.org/W2124536446","https://openalex.org/W2126043008","https://openalex.org/W2127113605","https://openalex.org/W2131876608","https://openalex.org/W2132292320","https://openalex.org/W2134964552","https://openalex.org/W2138319716","https://openalex.org/W2141744105","https://openalex.org/W2143851306","https://openalex.org/W2145221907","https://openalex.org/W2147594695","https://openalex.org/W2151130042","https://openalex.org/W2152820595","https://openalex.org/W2155445915","https://openalex.org/W2159620999","https://openalex.org/W2165002727","https://openalex.org/W2169448800","https://openalex.org/W2171769888","https://openalex.org/W2275877493","https://openalex.org/W2328559957","https://openalex.org/W2331253186","https://openalex.org/W2341084019","https://openalex.org/W2564133273","https://openalex.org/W6643485910","https://openalex.org/W6675219529"],"related_works":["https://openalex.org/W7100030944","https://openalex.org/W2084821546","https://openalex.org/W1522420112","https://openalex.org/W1992257057","https://openalex.org/W7154706328","https://openalex.org/W2333612033","https://openalex.org/W2048501945","https://openalex.org/W3146457662","https://openalex.org/W1965766554","https://openalex.org/W2080127092"],"abstract_inverted_index":{"Mammalian":[0],"target":[1],"of":[2,26,48,58,94,102,113],"rapamycin":[3,14],"(mTOR)":[4],"is":[5,37,76,96],"aberrantly":[6],"activated":[7],"in":[8,39,78,121],"many":[9],"cancer":[10],"types,":[11],"and":[12,22,83,87,117],"two":[13],"derivatives":[15],"are":[16],"currently":[17],"approved":[18],"by":[19],"the":[20,27,45,55,100,110],"Food":[21],"Drug":[23],"Administration":[24],"(FDA)":[25],"United":[28],"States":[29],"for":[30],"treating":[31],"renal":[32],"cell":[33,79,81],"carcinoma.":[34],"Mechanistically,":[35],"mTOR":[36,103],"hyperactivated":[38],"human":[40],"cancers":[41],"either":[42],"due":[43],"to":[44,97],"genetic":[46,56],"activation":[47],"its":[49,59],"upstream":[50],"activating":[51],"signaling":[52],"pathways":[53],"or":[54],"inactivation":[57],"negative":[60,115],"regulators.":[61],"The":[62],"tumor":[63,85],"suppressor":[64],"liver":[65],"kinase":[66,73],"B1":[67],"(LKB1),":[68],"also":[69],"known":[70],"as":[71],"serine/threonine":[72],"11":[74],"(STK11),":[75],"involved":[77],"polarity,":[80],"detachment":[82],"adhesion,":[84],"metastasis,":[86],"energetic":[88],"stress":[89],"response.":[90],"A":[91],"key":[92],"role":[93],"LKB1":[95],"negatively":[98],"regulate":[99],"activity":[101],"complex":[104],"1":[105],"(mTORC1).":[106],"This":[107],"review":[108],"summarizes":[109],"molecular":[111],"basis":[112],"this":[114,122],"interaction":[116],"recent":[118],"research":[119],"progress":[120],"area.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}